Results 91 to 100 of about 175,144 (193)

Inhibition of cholera toxin activation of the adenylate cyclase system in intact HeLa cells

, 1980
Cholera toxin treatment activates the adenylate cyclase in intact HeLa cells. However, pretreatment of the cells with chemicals known to inhibit receptor internalization and lysosomal processing blocks the toxin include methylamine, ammonium chloride ...
Lin, MC, Taniuchi, M
core  

The adenylate cyclase-mediated signaling pathway required for regulating siderophore and toxin biosynthesis and pathogenicity in Alternaria alternata

Frontiers in Fungal Biology
The role of cyclic AMP–protein kinase A (PKA) signaling in siderophore-mediated iron uptake and its connection to virulence remains poorly understood in phytopathogenic fungi. Genetic studies demonstrate that the A.
Kai-Chu Huang, Kai-Chu Huang, Hsin-Yu Lu, Hsin-Yu Lu, Celine Yen Ling Choo, Pei-Ching Wu, Kuang-Ren Chung, Kuang-Ren Chung   +7 more
doaj   +1 more source

Essential role of GTP in the expression of adenylate cyclase activity after cholera toxin treatment

, 1978
Expression of activation of rat liver adenylate cyclase by the A 1 peptide of cholera toxin and NAD is dependent on GTP. The nucleotide is effective either when added to the assay medium or during toxin (and NAD) treatment.
Lin, MC, Berman, MF, Welton, AF
core  

Cholera toxin A1 residues single alanine substitutional mutation and effect on activity with stimulatory G protein

Asian Pacific Journal of Tropical Biomedicine, 2017
Cholera is a well-known gastrointestinal infection. The cholera toxin is an important pathological substance in pathogenesis of cholera diarrhea. Cholera toxin is composed of catalytic A1 subunit, an A2 linker, and a homopentameric cell-binding B subunit.
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source

Stimulation by cholera toxin of ADP-ribosylation of membrane proteins, adenylate cyclase and insulilin release in pancreatic islets

, 1985
In rat pancreatic islet membranes exposed to [α–32P]NAD, cholera toxin stimulated the labelling of three peptides with Mr close to 22000, 42000 and 48000, respectively.
Dufrane, Simon, Svoboda, Michal, Garcia-Morales, Pilar   +2 more
core   +1 more source

Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications

Toxins, 2017
The isolated Block V repeats-in-toxin (RTX) peptide domain of adenylate cyclase (CyaA) from Bordetella pertussis reversibly folds into a β-roll secondary structure upon calcium binding.
Beyza Bulutoglu, Scott Banta
doaj   +1 more source

CCK and gastrin inhibit adenylate cyclase activity through a pertussis toxin-sensitive mechanism in the tumoral rat pancreatic acinar cell line AR 4-2J [PDF]

, 1988
(Thr28,Nle31)CCK(23-33) (CCK-9) and gastrin(1-17)1 (gastrin) inhibited adenylate cyclase activity in membranes from the tumoral rat pancreatic acinar cell line AR 4-2J through a Bordetella pertussis toxin-sensitive mechanism.
Rao, Bhagyashree, Christophe, Jean, MacFarlane, Gordon, Scemama, J.L., Parikh, Nayana, Waelbroeck, Magali, Vaysse, Nicole, Ersfeld, Diana, Polinske, Amy, Olson, Gregory T., Robberecht, Patrick, Eskridge, Tar Lisha, Pradayrol, L., De Neef, Philippe, Sackrison Jr. James, Pradayrol, Lucien, Scemama, Jean Luc, Miller, Andrew, Vaysse, N.   +18 more
core   +1 more source

Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin [PDF]

, 2010
Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional
Mohammed, Hesham Hamada Taha
core   +1 more source

Mechanisms of Pertussis Toxin Action: ADP-Ribosylation and Its Role in Pertussis Pathogenesis

Toxins
Pertussis toxin (PTx) is a major virulence factor of Bordetella pertussis and an AB5-type exotoxin that disrupts host signaling. Its enzymatic A subunit ADP-ribosylates the α-subunit of inhibitory G proteins (Gαi), preventing them from mediating receptor-
Qing Tang, Ho Yung Chan, Yanxi Huang, Yung H. Wong   +3 more
doaj   +1 more source

Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model

Toxins, 2016
Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis.
Taoran Zhao, Xinghui Zhao, Ju Liu, Yingying Meng, Yingying Feng, Ting Fang, Jinlong Zhang, Xiuxu Yang, Jianmin Li, Junjie Xu, Wei Chen   +10 more
doaj   +1 more source