Results 101 to 110 of about 23,918 (199)

Anti-phage islands force their target phage to directly mediate island excision and spread. [PDF]

, 2018
Vibrio cholerae, the causative agent of the diarrheal disease cholera, is antagonized by the lytic phage ICP1 in the aquatic environment and in human hosts. Mobile genetic elements called PLEs (phage-inducible chromosomal island-like elements) protect V.
McKitterick, Amelia C, Seed, Kimberley D
core   +1 more source

Cholera toxin A1 residues single alanine substitutional mutation and effect on activity with stimulatory G protein

Asian Pacific Journal of Tropical Biomedicine, 2017
Cholera is a well-known gastrointestinal infection. The cholera toxin is an important pathological substance in pathogenesis of cholera diarrhea. Cholera toxin is composed of catalytic A1 subunit, an A2 linker, and a homopentameric cell-binding B subunit.
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source

GABAB receptors regulate extrasynaptic GABAA receptors [PDF]

, 2013
Tonic inhibitory GABAA receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells.
Connelly, William M., Cope, David W., Crunelli, Vincenzo, Di Giovanni, Giuseppe, Errington, Adam C., Fyson, Sarah J., McCafferty, Cian P.   +6 more
core   +1 more source

Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications

Toxins, 2017
The isolated Block V repeats-in-toxin (RTX) peptide domain of adenylate cyclase (CyaA) from Bordetella pertussis reversibly folds into a β-roll secondary structure upon calcium binding.
Beyza Bulutoglu, Scott Banta
doaj   +1 more source

Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene [PDF]

, 2004
Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural circuits.
Baines, Richard A., Mee, Christopher J., Moffat, Kevin G., Pym, Edward C. G.   +3 more
core   +1 more source

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
core  

Cloning and optimization of expression and purification of the catalytic domain of adenylate cyclase toxin from an Iranian strain of Bordetella pertussis [PDF]

, 2016
زمینه و هدف: توکسین آدنیلات سیکلاز (Adenylate cyclas Toxin= ACT) یکی از فاکتور های ویرولانس ترشحی و ایمونوژنیک بوردتلا پرتوسیس است که دارای یک دمین کاتالیزوری با 400 اسید آمینه، به نام AC، در ناحیه N- ترمینال خود می باشد.
Badmasti, F., Bagbani -Arani, F., Hashei jezeh, H., Shahcheraghi, F.   +3 more
core  

Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model

Toxins, 2016
Edema toxin (ET), which is composed of a potent adenylate cyclase (AC), edema factor (EF), and protective antigen (PA), is one of the major toxicity factors of Bacillus anthracis.
Taoran Zhao, Xinghui Zhao, Ju Liu, Yingying Meng, Yingying Feng, Ting Fang, Jinlong Zhang, Xiuxu Yang, Jianmin Li, Junjie Xu, Wei Chen   +10 more
doaj   +1 more source

Adenylate cyclase toxin of Bordetella parapertussis disrupts the epithelial barrier granting the bacterial access to the intracellular space of epithelial cells. [PDF]

PLoS One, 2023
Gorgojo JP, Carrica MDC, Baroli CM, Valdez HA, Alvarez Hayes J, Rodriguez ME.   +5 more
europepmc   +1 more source

The adenylate cyclase toxin RTX domain follows a series templated folding mechanism with implications for toxin activity. [PDF]

J Biol Chem, 2023
Chen G, Wang H, Bumba L, Masin J, Sebo P, Li H.   +5 more
europepmc   +1 more source