Results 111 to 120 of about 175,144 (193)

Four Cholesterol-Recognition Motifs in the Pore-Forming and Translocation Domains of Adenylate Cyclase Toxin Are Essential for Invasion of Eukaryotic Cells and Lysis of Erythrocytes. [PDF]

Int J Mol Sci, 2022
Amuategi J, Alonso R, Ostolaza H.
europepmc   +1 more source

Structural-functional aspects of the Bordetella pertussis adenylate cyclase toxin

, 2023
Whooping cough (pertussis) is a highly infectious respiratory disease caused by the Gram-negative bacterium Bordetella pertussis. Even though the vaccination rate of the population is high, pertussis is one of the most widespread vaccine-preventable ...
Březinová, Karolína
core  

Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes. [PDF]

PLoS Pathog, 2021
Goldsmith JA, DiVenere AM, Maynard JA, McLellan JS.   +3 more
europepmc   +1 more source

Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein. [PDF]

Int J Mol Sci, 2021
Malandra A, Rahman WU, Klimova N, Streparola G, Holubova J, Osickova A, Bariselli S, Sebo P, Osicka R.   +8 more
europepmc   +1 more source

WR-2721 inhibits parathyroid adenylate cyclase

, 1987
WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid] is a chemoprotective and radioprotective agent that has been shown to lower serum calcium in dogs and in humans.
E. Slatopolsky, K. J. Martin, S. Goldfarb, C. McConkey, J. Morrissey, M. E. Weaver   +5 more
core   +1 more source

Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization

mSphere
The adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes.
Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo   +6 more
doaj   +1 more source

Dissociation by cooling of hormone and cholera toxin activation of adenylate cyclase in intact cells.

, 1979
Cholera toxin, through adenylate cyclase activation reproduced cyclic AMP-mediated effects of thyroid-stimulating hormone (TSH) in dog thyroid slices, i.e. protein iodination, [1-14C]glucose-oxidation and hormone secretion.
Dumont, Jacques Emile, Pochet, Roland, Van Sande, Jacqueline   +2 more
core  

Susceptibility of Human Airway Tissue Models Derived From Different Anatomical Sites to Bordetella pertussis and Its Virulence Factor Adenylate Cyclase Toxin. [PDF]

Front Cell Infect Microbiol, 2021
Sivarajan R, Kessie DK, Oberwinkler H, Pallmann N, Walles T, Scherzad A, Hackenberg S, Steinke M.   +7 more
europepmc   +1 more source

Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size. [PDF]

FEBS J, 2021
González Bullón D, Uribe KB, Amuategi J, Martín C, Ostolaza H.   +4 more
europepmc   +1 more source

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin. [PDF]

J Biol Chem, 2021
Espinosa-Vinals CA, Masin J, Holubova J, Stanek O, Jurnecka D, Osicka R, Sebo P, Bumba L.   +7 more
europepmc   +1 more source