Prevalence of Pertactin-Deficient Bordetella pertussis Isolates, Slovenia [PDF]
Emerging Infectious DiseasesIn Slovenia, primary acellular pertussis vaccines (ACVs) containing pertactin (PRN) were mostly used during 1999–2016; ACVs without PRN were introduced in 2017.
Alex-Mikael Barkoff +5 more
doaj +4 more sources
Pertactin contributes to shedding and transmission of Bordetella bronchiseptica.
PLoS Pathogens, 2021 Whooping cough is resurging in the United States despite high vaccine coverage. The rapid rise of Bordetella pertussis isolates lacking pertactin (PRN), a key vaccine antigen, has led to concerns about vaccine-driven evolution.
Longhuan Ma +9 more
doaj +5 more sources
Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor. [PDF]
Emerging Microbes & Infections, 2018 Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries ...
Hamstra, Hendrik-Jan +9 more
core +19 more sources
Variation in virulence between three representative Bordetella pertussis pertactin-negative clinical isolates [PDF]
mSpherePertussis is a respiratory disease caused by the bacterium Bordetella pertussis. Acellular pertussis (aP) vaccines replaced more reactogenic whole-cell pertussis (wP) vaccines in the United States in the 1990s.
Nicole Lamond +10 more
doaj +2 more sources
Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization [PDF]
mSphereThe adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes.
Carlos Espinosa-Vinals +6 more
doaj +2 more sources
Revisiting Whooping Cough: Global Drivers and Implications of Pertussis Resurgence in the Acellular Vaccine Era [PDF]
VaccinesBackground: Whooping cough caused by Bordetella pertussis is re-emerging despite high vaccination coverage, with rising incidence in adolescents and adults in the acellular vaccine (aP) era.
Siheng Zhang, Yan Xu, Ying Xiao
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Pathogenicity and vaccine protection of circulating pertactin- and filamentous hemagglutinin-deficient Bordetella pertussis strains [PDF]
Emerging Microbes and InfectionsThe increasing emergence of vaccine antigen-deficient Bordetella pertussis (Bp) variants has raised concerns regarding disease control and prevention. Here, we characterized the pathogenicity and vaccine protection of circulating pertactin-deficient (PRN−
Hanying Dai +16 more
doaj +2 more sources
Pertactin deficiency of Bordetella pertussis: Insights into epidemiology, and perspectives on surveillance and public health impact [PDF]
Human Vaccines & ImmunotherapeuticsPertussis resurgence has been documented even in countries with high pediatric vaccine coverage. The proportion of Bordetella pertussis isolates not expressing pertactin (PRN) has increased in several countries where acellular pertussis (aP) vaccines are
Ulrich Heininger +7 more
doaj +2 more sources
In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionVarious strains emerged in B. pertussis re-emergence, the pathogenic characteristics and mechanisms remain elusive. We aimed to explore the relationship between the in vivo transcriptome and colonization advantage of various pertussis ...
Weilun Zuo +14 more
doaj +2 more sources
As pertussis returns to pre-COVID19 endemicity, vaccination remains our best ally against an evolving Bordetella pertussis [PDF]
Emerging Microbes and InfectionsZeng Mei, Macina Denis
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