Results 1 to 10 of about 2,457 (145)

Pertactin-negative Bordetella pertussis strains in Canada: characterization of a dozen isolates based on a survey of 224 samples collected in different parts of the country over the last 20 years [PDF]

International Journal of Infectious Diseases, 2014
Objective: To detect and characterize pertactin-negative Bordetella pertussis in Canada, especially for isolates collected in recent years. Methods: A total of 224 isolates from the years 1994–2013 were screened by Western immuno-blot for expression of ...
Steven Drews, Frances B Jamieson, Shalini Desai   +2 more
exaly   +4 more sources

Prevalence of Pertactin-Deficient Bordetella pertussis Isolates, Slovenia [PDF]

Emerging Infectious Diseases
In Slovenia, primary acellular pertussis vaccines (ACVs) containing pertactin (PRN) were mostly used during 1999–2016; ACVs without PRN were introduced in 2017.
Alex-Mikael Barkoff, Tamara Kastrin, Katja Seme, Marta Grgič Vitek, Jussi Mertsola, Qiushui He   +5 more
doaj   +4 more sources

Emergence of pertactin-deficient pertussis strains in Australia can be explained by models of vaccine escape

Epidemics, 2020
A number of developed countries including Australia have experienced significant pertussis outbreaks in recent years despite consistent high levels of vaccine coverage.
Duleepa Jayasundara, Sophie Octavia, Ruiting Lan   +2 more
exaly   +4 more sources

Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains

Frontiers in Microbiology, 2020
Despite high vaccination coverage, Bordetella pertussis the causative agent of whooping cough is still a health concern worldwide. A resurgence of pertussis cases has been reported, particularly in countries using acellular vaccines with waning immunity ...
Breeze Cavell, Stephen Taylor, Cecile van Els   +2 more
exaly   +4 more sources

Variation in virulence between three representative Bordetella pertussis pertactin-negative clinical isolates [PDF]

mSphere
Pertussis is a respiratory disease caused by the bacterium Bordetella pertussis. Acellular pertussis (aP) vaccines replaced more reactogenic whole-cell pertussis (wP) vaccines in the United States in the 1990s.
Nicole Lamond, Lindsey Zimmerman, Yihui Wang, Jonatan Maldonado Villeda, Asgeir Bjarnason, Hekla Bryndís Jóhannsdóttir, Tami H. Skoff, Maria-Lucia Tondella, Michael R. Weigand, Susan Hariri, Tod Merkel   +10 more
doaj   +3 more sources

Development of High-Throughput Serum Bactericidal Assays for Bordetella pertussis to Evaluate BPZE1 [PDF]

Vaccines
Background/Objectives: Pertussis, caused by Bordetella pertussis, remains a global health problem, despite high vaccine coverage. In countries with high acellular pertussis vaccine (aPV) coverage, pertactin-negative B.
Peter Goldstein, Tania Gensale, Shannon Harris, Tina M. Green, Stephanie Noviello, Keith Rubin, Camille Locht, Breeze Cavell, Andrew Gorringe, Luc Gagnon   +9 more
doaj   +2 more sources

The evolution of pertactin expression in Belgian circulating B. pertussis strains, pre- and post-COVID-19 [PDF]

Microbiology Spectrum
Prior to the COVID-19 pandemic, Bordetella pertussis strains not producing pertactin were globally increasing, especially in countries using the acellular pertussis vaccine. Subsequently, during the pandemic, global pertussis incidence dropped to extreme
Helena Martini, Oriane Soetens, Vili Niinikoski, Alex-Mikael Barkoff, Qiushui He, Denis Piérard, Eveline Van Honacker   +6 more
doaj   +2 more sources

Flow Cytometric Assessment of Pertactin- and Tetanus Toxoid-Specific B-Cell Kinetics After Tdap Booster Vaccination in Healthy Adults [PDF]

Vaccines
Background: Despite its high vaccination coverage, pertussis remains a public health concern due to waning vaccine-induced immunity and the emergence of pertactin (Prn)-negative strains.
Mirjam J. Esser, Annieck M. Diks, Liesbeth E. M. Oosten, Rick J. Groenland, Bas de Mooij, Cristina Teodosio, Gertjan J. A. Driessen, Jacques J. M. van Dongen, Magdalena A. Berkowska   +8 more
doaj   +2 more sources

Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization [PDF]

mSphere
The adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes.
Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo   +6 more
doaj   +2 more sources

Revisiting Whooping Cough: Global Drivers and Implications of Pertussis Resurgence in the Acellular Vaccine Era [PDF]

Vaccines
Background: Whooping cough caused by Bordetella pertussis is re-emerging despite high vaccination coverage, with rising incidence in adolescents and adults in the acellular vaccine (aP) era.
Siheng Zhang, Yan Xu, Ying Xiao
doaj   +2 more sources