Results 21 to 30 of about 2,457 (145)
Emerging Infectious Diseases, 2001 Recently, eight allelic variants of the pertactin gene (prn1-8) have been characterized in Bordetella pertussis strains isolated in Europe and the United States.
Johanna Mäkinen +4 more
doaj +2 more sources
Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia [PDF]
Emerging Infectious Diseases, 2014 Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008–2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B.
Connie Lam +13 more
doaj +2 more sources
Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan. [PDF]
PLoS ONE, 2012 The adhesin pertactin (Prn) is one of the major virulence factors of Bordetella pertussis, the etiological agent of whooping cough. However, a significant prevalence of Prn-deficient (Prn(-)) B. pertussis was observed in Japan.
Nao Otsuka +6 more
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Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor [PDF]
Emerging Microbes and Infections, 2018 Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries ...
Elise Sofie Hovingh +9 more
doaj +3 more sources
Pertactin contributes to shedding and transmission of Bordetella bronchiseptica.
PLoS Pathogens, 2021 Whooping cough is resurging in the United States despite high vaccine coverage. The rapid rise of Bordetella pertussis isolates lacking pertactin (PRN), a key vaccine antigen, has led to concerns about vaccine-driven evolution.
Longhuan Ma +9 more
doaj +2 more sources
As pertussis returns to pre-COVID19 endemicity, vaccination remains our best ally against an evolving Bordetella pertussis [PDF]
Emerging Microbes and InfectionsZeng Mei, Macina Denis
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Microbiology and Immunology, Volume 67, Issue 6, Page 314-317, June 2023., 2023 Abstract Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B.
Koichiro Suzuki +3 more
wiley +1 more source
Modeling the effect of oxidative stress on Bordetella pertussis fermentations
Biotechnology Progress, Volume 39, Issue 3, May/June 2023., 2023 Abstract A mathematical model is proposed for Bordetella pertussis with the main goal to better understand and describe the relation between cell growth, oxidative stress and NADPH levels under different oxidative conditions. The model is validated with flask experiments conducted under different conditions of oxidative stress induced by high initial ...
Michael Vitelli +3 more
wiley +1 more source
Journal of Tropical Medicine, Volume 2022, Issue 1, 2022., 2022 The objective of this meta‐analysis is to assess the safety and immunogenicity of maternal pertussis vaccination based on randomized clinical trials. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, and Wan Fang Database were searched from inception up to the 8th of October 2021, using a protocol registered on ...
Aidibai Simayi +3 more
wiley +1 more source
Vaccines, 2023 There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present ethical concerns. The development of relevant in vitro assays is part of the solution.
Jason Szeto +17 more
doaj +1 more source