Results 21 to 30 of about 3,408 (187)

Etymologia: Pertactin

Emerging Infectious Diseases, 2014
doaj   +2 more sources

Adaptive evolution of the Bordetella autotransporter pertactin [PDF]

Journal of Evolutionary Biology, 2006
Abstract The virulence factor pertactin is expressed by the closely related pathogens Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Pertactin is an autotransporter involved in adherence of Bordetella species to the lung epithelium of mammalian hosts, and it is an important component of most current ...
Diavatopoulos, DA, Hijnen, M, Mooi, FRrivm   +2 more
openaire   +3 more sources

Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells

Emerging Microbes and Infections, 2021
Respiratory infections caused by Bordetella pertussis are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating B.
Michiel M. Kroes, Alberto Miranda-Bedate, Elise S. Hovingh, Ronald Jacobi, Corrie Schot, Elder Pupo, René H. M. Raeven, Arno A. J. van der Ark, Jos P. M. van Putten, Jelle de Wit, Rob Mariman, Elena Pinelli   +11 more
doaj   +1 more source

Clinical Manifestations and Molecular Characterization of Pertactin-Deficient and Pertactin-ProducingBordetella pertussisin Children, Philadelphia 2007–2014 [PDF]

Clinical Infectious Diseases, 2016
 Bordetella pertussis strains lacking expression of pertactin, a bacterial adhesin and vaccine target, are emerging. There are limited data on disease manifestations of mutant strains in children. We sought to compare clinical manifestations of pertactin-deficient and pertactin-producing B.
Jennifer, Vodzak, Anne Marie, Queenan, Emily, Souder, Alan T, Evangelista, Sarah S, Long   +4 more
openaire   +2 more sources

Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice

Microbiology and Immunology, Volume 67, Issue 6, Page 314-317, June 2023., 2023
Abstract Bordetella pertussis causes pertussis, which is characterized by paroxysmal coughing. This disease is generally prevented through vaccination; however, the number of pertussis cases is increasing worldwide despite high vaccination coverage. We previously reported that an autotransporter of B.
Koichiro Suzuki, Yukihiro Hiramatsu, Takashi Nishida, Yasuhiko Horiguchi   +3 more
wiley   +1 more source

Modeling the effect of oxidative stress on Bordetella pertussis fermentations

Biotechnology Progress, Volume 39, Issue 3, May/June 2023., 2023
Abstract A mathematical model is proposed for Bordetella pertussis with the main goal to better understand and describe the relation between cell growth, oxidative stress and NADPH levels under different oxidative conditions. The model is validated with flask experiments conducted under different conditions of oxidative stress induced by high initial ...
Michael Vitelli, Ibrahim Melih Tamer, Mark Pritzker, Hector Budman   +3 more
wiley   +1 more source

Safety and Immunogenicity of Pertussis Vaccine Immunization during Pregnancy: A Meta‐Analysis of Randomized Clinical Trials

Journal of Tropical Medicine, Volume 2022, Issue 1, 2022., 2022
The objective of this meta‐analysis is to assess the safety and immunogenicity of maternal pertussis vaccination based on randomized clinical trials. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Internet, and Wan Fang Database were searched from inception up to the 8th of October 2021, using a protocol registered on ...
Aidibai Simayi, Liguo Zhu, Hui Jin, Maoshui Wang   +3 more
wiley   +1 more source

Antibodies binding diverse pertactin epitopes protect mice from Bordetella pertussis infection [PDF]

Journal of Biological Chemistry, 2022
Infection by the bacterium Bordetella pertussis continues to cause considerable morbidity and mortality worldwide. Many current acellular pertussis vaccines include the antigen pertactin, which has presumptive adhesive and immunomodulatory activities, but is rapidly lost from clinical isolates after the introduction of these vaccines.
Rui P. Silva, Andrea M. DiVenere, Dzifa Amengor, Jennifer A. Maynard   +3 more
openaire   +2 more sources

Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines

Vaccines, 2023
There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present ethical concerns. The development of relevant in vitro assays is part of the solution.
Jason Szeto, Aruun Beharry, Tricia Chen, Eric Zholumbetov, Emilie Daigneault, Marin Ming, Iain Lounsbury, Nelson Eng, Nemika Thangavadivel, Robbie Jin, Aurélie Denis-Jacquot, Bahram Behnam Azad, Meili Li, Diana Keizner, Marcus Liu, Sophia S. F. Lee, Kai He, Beata Gajewska   +17 more
doaj   +1 more source

Cardiopulmonary Arrest and Pulmonary Hypertension in an Infant with Pertussis Case Report

Case Reports in Infectious Diseases, Volume 2021, Issue 1, 2021., 2021
Pertussis is a vaccine‐preventable disease with an incidence that has been trending upwards in the United States over the last two decades. This is evident by an increase in the incidence from 10,100 cases in 1974 to a peak of >48,000 cases noted in the last decade.
Patrick Ovie Fueta, Harry Onoriode Eyituoyo, Oghogho Igbinoba, Jon Roberts, Dawei Cui   +4 more
wiley   +1 more source