Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells [PDF]
Emerging Microbes and Infections, 2021 Respiratory infections caused by Bordetella pertussis are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating B.
Michiel M. Kroes +11 more
doaj +3 more sources
Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor [PDF]
Emerging Microbes and Infections, 2018 Whooping cough, caused by Bordetella pertussis, has resurged and presents a global health burden worldwide. B. pertussis strains unable to produce the acellular pertussis vaccine component pertactin (Prn), have been emerging and in some countries ...
Elise Sofie Hovingh +9 more
doaj +4 more sources
Pertactin contributes to shedding and transmission of Bordetella bronchiseptica.
PLoS Pathogens, 2021 Whooping cough is resurging in the United States despite high vaccine coverage. The rapid rise of Bordetella pertussis isolates lacking pertactin (PRN), a key vaccine antigen, has led to concerns about vaccine-driven evolution.
Longhuan Ma +9 more
doaj +5 more sources
Crucial role of antibodies to pertactin in Bordetella pertussis immunity [PDF]
The Journal of Infectious Diseases, 2003 Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity ...
Hellwig, SMM +4 more
core +11 more sources
Adaptive evolution of the Bordetella autotransporter pertactin [PDF]
Journal of Evolutionary Biology, 2006 Abstract The virulence factor pertactin is expressed by the closely related pathogens Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Pertactin is an autotransporter involved in adherence of Bordetella species to the lung epithelium of mammalian hosts, and it is an important component of most current ...
Dimitri A. Diavatopoulos +2 more
openalex +4 more sources
Complete Genome Sequences of Bordetella pertussis Isolates with Novel Pertactin-Deficient Deletions [PDF]
, 2017 Clinical isolates of the respiratory pathogen Bordetella pertussis in the United States have become predominantly deficient for the acellular vaccine immunogen pertactin through various independent mutations.
Michael R. Weigand +9 more
openalex +2 more sources
Pertactin Is Required forBordetellaSpecies To Resist Neutrophil-Mediated Clearance [PDF]
Infection and Immunity, 2010 ABSTRACTPertactin (PRN) is an autotransporter protein produced by all members of theBordetella bronchisepticacluster, which includesB. pertussis,B. parapertussis, andB. bronchiseptica. It is a primary component of acellular pertussis vaccines, and anti-PRN antibody titers correlate with protection.In vitrostudies have suggested that PRN functions as an
Carol Inatsuka +6 more
openalex +4 more sources
, 2016 Development of acellular pertussis vaccine (aPV) requires purification of several components from Bordetella pertussis. While the components pertussis toxin (PT) and filamentous hemagglutinin (FHA) have been successfully purified, the third component ...
Zenglan Li +9 more
openalex +3 more sources
Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children [PDF]
, 2000 Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanuspertussis vaccine in atopic versus nonatopic ...
Patrick G. Holt +6 more
openalex +2 more sources