Emerging Infectious Diseases, 2022 Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481.
Alba Mir-Cros +19 more
doaj +10 more sources
Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin [PDF]
Emerging Infectious Diseases, 2016 A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013.
Margaret M. Williams +6 more
doaj +3 more sources
Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina [PDF]
Emerging Infectious Diseases, 2019 Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine.
Francisco Carriquiriborde +6 more
doaj +4 more sources
Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan
Emerging Infectious Diseases, 2017 Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014–2016 (8%) was significantly lower than the frequency in 2005–2007 (41 ...
Yukihiro Hiramatsu +5 more
doaj +3 more sources
Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains [PDF]
Frontiers in Microbiology, 2020 Despite high vaccination coverage, Bordetella pertussis the causative agent of whooping cough is still a health concern worldwide. A resurgence of pertussis cases has been reported, particularly in countries using acellular vaccines with waning immunity ...
Elodie Lesne +8 more
doaj +5 more sources
Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia
Emerging Infectious Diseases, 2014 Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008–2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B.
Connie Lam +13 more
doaj +4 more sources
Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis [PDF]
Emerging Infectious Diseases, 2021 Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Longhuan Ma +3 more
doaj +3 more sources
Virulence of Pertactin-Negative Bordetella pertussis Isolates from Infants, France [PDF]
Emerging Infectious Diseases, 2013 Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants
Hélène Bodilis, Nicole Guiso
doaj +3 more sources
Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan. [PDF]
PLoS ONE, 2012 The adhesin pertactin (Prn) is one of the major virulence factors of Bordetella pertussis, the etiological agent of whooping cough. However, a significant prevalence of Prn-deficient (Prn(-)) B. pertussis was observed in Japan.
Nao Otsuka +6 more
doaj +4 more sources
Pertactin-Negative and Filamentous Hemagglutinin-Negative Bordetella pertussis, Australia, 2013–2017 [PDF]
Emerging Infectious Diseases, 2019 During the 2008–2012 pertussis epidemic in Australia, pertactin (Prn)–negative Bordetella pertussis emerged. We analyzed 78 isolates from the 2013–2017 epidemic and documented continued expansion of Prn-negative ptxP3 B. pertussis strains.
Zheng Xu +9 more
doaj +4 more sources