Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018 [PDF]
Emerging Infectious Diseases, 2022 Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481.
Alba Mir-Cros +19 more
doaj +12 more sources
Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin [PDF]
Emerging Infectious Diseases, 2016 A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013.
Margaret M. Williams +6 more
doaj +5 more sources
Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains [PDF]
Frontiers in Microbiology, 2020 Despite high vaccination coverage, Bordetella pertussis the causative agent of whooping cough is still a health concern worldwide. A resurgence of pertussis cases has been reported, particularly in countries using acellular vaccines with waning immunity ...
Elodie Lesne +8 more
doaj +7 more sources
Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina [PDF]
Emerging Infectious Diseases, 2019 Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine.
Francisco Carriquiriborde +6 more
doaj +7 more sources
Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia [PDF]
Emerging Infectious Diseases, 2014 Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008–2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B.
Connie Lam +13 more
doaj +7 more sources
Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan. [PDF]
PLoS ONE, 2012 The adhesin pertactin (Prn) is one of the major virulence factors of Bordetella pertussis, the etiological agent of whooping cough. However, a significant prevalence of Prn-deficient (Prn(-)) B. pertussis was observed in Japan.
Nao Otsuka +6 more
doaj +6 more sources
Pertactin deficiency of Bordetella pertussis: Insights into epidemiology, and perspectives on surveillance and public health impact [PDF]
Human Vaccines & ImmunotherapeuticsPertussis resurgence has been documented even in countries with high pediatric vaccine coverage. The proportion of Bordetella pertussis isolates not expressing pertactin (PRN) has increased in several countries where acellular pertussis (aP) vaccines are
Ulrich Heininger +7 more
doaj +4 more sources
Determination of pertactin IgG antibodies for the diagnosis of pertussis [PDF]
Clinical Microbiology and Infection, 2003 ObjectiveTo compare increases in serum IgG antibody against pertactin with increases in IgG against pertussis toxin and filamentous hemagglutinin (FHA) in non-vaccinated children, children vaccinated with pertussis toxoid, and adults, all with culture ...
Birger Trollfors +3 more
core +4 more sources
Significant Decrease in Pertactin-Deficient Bordetella pertussis Isolates, Japan [PDF]
Emerging Infectious Diseases, 2017 Prevalence of pertactin-lacking Bordetella pertussis isolates has been observed worldwide. In Japan, however, we found that the frequency of pertactin-deficient isolates in 2014–2016 (8%) was significantly lower than the frequency in 2005–2007 (41 ...
Yukihiro Hiramatsu +5 more
doaj +4 more sources
Dynamics and Energy Contributions for Transport of Unfolded Pertactin through a Protein Nanopore [PDF]
ACS Nano, 2015 To evaluate the physical parameters governing translocation of an unfolded protein across a lipid bilayer, we studied protein transport through aerolysin, a passive protein channel, at the single-molecule level.
Benjamin Cressiot +5 more
core +6 more sources