Results 11 to 20 of about 2,457 (145)

Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986–2018 [PDF]

Emerging Infectious Diseases, 2022
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481.
Alba Mir-Cros, Albert Moreno-Mingorance, M. Teresa Martín-Gómez, Raquel Abad, Iván Bloise, Magda Campins, Alejandro González-Praetorius, M. Nieves Gutiérrez, Héctor Martín-González, Carmen Muñoz-Almagro, M. Ángeles Orellana, Manuela de Pablos, Josep Roca-Grande, Carlos Rodrigo, M. Elena Rodríguez, Sonia Uriona, M. José Vidal, Tomàs Pumarola, M. Nieves Larrosa, Juan José González-López   +19 more
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Pertactin deficiency of Bordetella pertussis: Insights into epidemiology, and perspectives on surveillance and public health impact [PDF]

Human Vaccines & Immunotherapeutics
Pertussis resurgence has been documented even in countries with high pediatric vaccine coverage. The proportion of Bordetella pertussis isolates not expressing pertactin (PRN) has increased in several countries where acellular pertussis (aP) vaccines are
Ulrich Heininger, Helena Martini, Jennifer Eeuwijk, Ivana Prokić, Adrienne P. Guignard, Elisa Turriani, Maurine Duchenne, Valérie Berlaimont   +7 more
doaj   +3 more sources

Rare Detection of Bordetella pertussis Pertactin-Deficient Strains in Argentina [PDF]

Emerging Infectious Diseases, 2019
Pertussis resurgence had been attributed to waning vaccine immunity and Bordetella pertussis adaptation to escape vaccine-induced immunity. Circulating bacteria differ genotypically from strains used in production of pertussis vaccine.
Francisco Carriquiriborde, Victoria Regidor, Pablo M. Aispuro, Gabrielli Magali, Erika Bartel, Daniela Bottero, Daniela Hozbor   +6 more
doaj   +2 more sources

Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin

Emerging Infectious Diseases, 2016
A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013.
Margaret M. Williams, Kathryn Sen, Michael R. Weigand, Tami H. Skoff, Victoria A. Cunningham, Tanya A. Halse, M. Lucia Tondella   +6 more
doaj   +2 more sources

Naturally circulating pertactin-deficient Bordetella pertussis strains induce distinct gene expression and inflammatory signatures in human dendritic cells [PDF]

Emerging Microbes and Infections, 2021
Respiratory infections caused by Bordetella pertussis are reemerging despite high pertussis vaccination coverage. Since the introduction of the acellular pertussis vaccine in the late twentieth century, circulating B.
Michiel M. Kroes, Alberto Miranda-Bedate, Elise S. Hovingh, Ronald Jacobi, Corrie Schot, Elder Pupo, René H. M. Raeven, Arno A. J. van der Ark, Jos P. M. van Putten, Jelle de Wit, Rob Mariman, Elena Pinelli   +11 more
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Pertactin-Negative and Filamentous Hemagglutinin-Negative Bordetella pertussis, Australia, 2013–2017 [PDF]

Emerging Infectious Diseases, 2019
During the 2008–2012 pertussis epidemic in Australia, pertactin (Prn)–negative Bordetella pertussis emerged. We analyzed 78 isolates from the 2013–2017 epidemic and documented continued expansion of Prn-negative ptxP3 B. pertussis strains.
Zheng Xu, Sophie Octavia, Laurence Don Wai Luu, Michael Payne, Verlaine Timms, Chin Yen Tay, Anthony D. Keil, Vitali Sintchenko, Nicole Guiso, Ruiting Lan   +9 more
doaj   +4 more sources

SphB1 export system for antigen presentation to the respiratory tract by a live pertussis vaccine [PDF]

Applied Microbiology and Biotechnology
BPZE1 is a live attenuated vaccine currently in advanced clinical development for nasal immunization against pertussis. The ability of this vaccine to induce mucosal and systemic, humoral and cellular immunity make it an attractive mucosal delivery ...
Lazara Elena Santiesteban-Lores, Dominique Raze, Violaine Dubois, Morgane Tardy, Anne-Sophie Debrie, Peter Goldstein, Loic Coutte, Camille Locht   +7 more
doaj   +2 more sources

Virulence of Pertactin-Negative Bordetella pertussis Isolates from Infants, France

Emerging Infectious Diseases, 2013
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants
Hélène Bodilis, Nicole Guiso
doaj   +2 more sources

In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionVarious strains emerged in B. pertussis re-emergence, the pathogenic characteristics and mechanisms remain elusive. We aimed to explore the relationship between the in vivo transcriptome and colonization advantage of various pertussis ...
Weilun Zuo, Weilun Zuo, Chen Wei, Meiyan He, Mengyao Zhang, Jiangli Liang, Xiao Ma, Na Gao, Qin Gu, Yan Ma, Jingyan Li, Shuyuan Liu, Yan Huang, Mingbo Sun, Li Shi   +14 more
doaj   +2 more sources

Pathogenicity and vaccine protection of circulating pertactin- and filamentous hemagglutinin-deficient Bordetella pertussis strains [PDF]

Emerging Microbes and Infections
The increasing emergence of vaccine antigen-deficient Bordetella pertussis (Bp) variants has raised concerns regarding disease control and prevention. Here, we characterized the pathogenicity and vaccine protection of circulating pertactin-deficient (PRN−
Hanying Dai, Xiuwen Sui, Jie Che, Chunying Zhang, Jiayu Zhao, Jie Li, Bohan Chen, Luyao Guo, Dongshan Yan, Hairui Wang, Xueping Liu, Li Xu, Yuan Gao, Aiping Qin, Tao Zhu, Maojun Zhang, Zhujun Shao   +16 more
doaj   +2 more sources