Results 41 to 50 of about 3,408 (187)

Simple Algorithm for Identification of Bordetella pertussis Pertactin Gene Variants [PDF]

Journal of Clinical Microbiology, 2004
ABSTRACT Studies performed in several countries have demonstrated the recent emergence and subsequent dominance of circulating Bordetella pertussis strains harboring pertactin and pertussis toxin variants not included in pertussis vaccines. Determination of the pertactin gene variants is commonly performed
Muyldermans, G, Pierard, D, Hoebekx, N, Advani, R, van Amersfoorth, S, de Schutter, I, Soetens, O, Eeckhout, L, Malfroot, A, Lauwers, S   +9 more
openaire   +4 more sources

Protection against pertussis in humans correlates to elevated serum antibodies and memory B cells [PDF]

, 2017
Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Carsetti, Rita, Di Mattia, G., Fedele, Giorgio, Frassanito, A., Gesualdo, Francesco, Leone, Pasqualina, Marcellini, Valentina, Midulla, Fabio, Mortari, Eva Piano, Nenna, R., Pandolfi, Elisabetta, Stefanelli, Paola, The Pertussis Study, Gropu, Tozzi, Alberto Eugenio   +13 more
core   +1 more source

Role of Evolutionary Selection Acting on Vaccine Antigens in the Re-Emergence of Bordetella Pertussis

Diseases, 2019
Pertussis (“whooping cough”) is a re-emerging disease with increasing incidence among fully vaccinated individuals. We explored the genetic diversity of five Bordetella pertussis proteins used to generate the subunit vaccine across ancestral and newly ...
Haley Etskovitz, Nicole Anastasio, Evangeline Green, Meghan May   +3 more
doaj   +1 more source

Protective Activity and Safety of Acellular Pertussis Vaccine from Vaccine and Freshly Isolated Strain Bordetella pertussis

Эпидемиология и вакцинопрофилактика, 2017
Goal. Study of the protective activity and safety of acellular pertussis vaccine (APV) using freshly isolated strain of B. pertussis. Materials and methods. Mice-hybrids F1 (CBAxC57Bl6). The B. pertussis strains: vaccine strains No. 305, No. 203, freshly
E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina   +2 more
doaj   +1 more source

Immunogenicity and safety of combined tetanus, reduced diphtheria, acellular pertussis vaccine when co-administered with quadrivalent meningococcal conjugate and human papillomavirus vaccines in healthy adolescents. [PDF]

, 2014
Objective: Current United States immunization recommendations for adolescents include vaccines against tetanus, diphtheria and pertussis (Tdap), human papillomavirus (HPV), and Neisseria meningitidis serogroups A, C, W-135, and Y. In this Phase IV study,
Alexanderian, David, Conversano, Michele, Garscadden, Alan, Gasparini, Roberto, Giglioli, Noemi, Han, Linda, Johnston, William, Percell, Sandra, Smolenov, Igor   +8 more
core   +1 more source

ALEPH: a network‐oriented approach for the generation of fragment‐based libraries and for structure interpretation

Acta Crystallographica Section D, Volume 76, Issue 3, Page 193-208, March 2020., 2020
ALEPH characterizes the main‐chain geometry of small, noncontinuous fragments to flexibly annotate secondary structure, decompose folds, extract libraries and superpose fragments. Secondary and tertiary structure are described through networks of characteristic vectors, which are defined between the centroids of the Cα and carbonyl O atoms in a peptide.
Ana Medina, Josep Triviño, Rafael J. Borges, Claudia Millán, Isabel Usón, Massimo D. Sammito   +5 more
wiley   +1 more source

Emergence of pertactin-deficient pertussis strains in Australia can be explained by models of vaccine escape

Epidemics, 2020
A number of developed countries including Australia have experienced significant pertussis outbreaks in recent years despite consistent high levels of vaccine coverage.
Duleepa Jayasundara, Edward Lee, Sophie Octavia, Ruiting Lan, Mark M. Tanaka, James G. Wood   +5 more
doaj   +1 more source

Entebbe Mother and Baby Study - Data at one year [PDF]

, 2017
Dataset and supporting documentation collected as part of the Entebbe Mother and Baby Study (EMaBS), a clinical trial that investigated potential benefits of treating worm infections during pregnancy and early childhood.
Elliott, Alison, Kizito, Dennison, Lule, Swaib A., Mentzer, Alexander J., Nash, Stephen, Smits, Gaby, van der Klis, Fiona R.M.   +6 more
core   +2 more sources

Development and Validation of a Bordetella pertussis Whole‐Genome Screening Strategy

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
The immune response elicited by the protective whole‐cell pertussis (wP) versus the less‐protective acellular pertussis (aP) vaccine has been well characterized; however, important clinical problems remain unsolved, as the inability of the currently administered aP vaccine is resulting in the reemergence of clinical disease (i.e., whooping cough ...
Ricardo da Silva Antunes, Lorenzo G. Quiambao, Aaron Sutherland, Ferran Soldevila, Sandeep Kumar Dhanda, Sandra K. Armstrong, Timothy J. Brickman, Tod Merkel, Bjoern Peters, Alessandro Sette, Pedro A. Reche   +10 more
wiley   +1 more source

Determination of pertactin IgG antibodies for the diagnosis of pertussis [PDF]

Clinical Microbiology and Infection, 2003
To compare increases in serum IgG antibody against pertactin with increases in IgG against pertussis toxin and filamentous hemagglutinin (FHA) in non-vaccinated children, children vaccinated with pertussis toxoid, and adults, all with culture-confirmed pertussis.During a double-blind, placebo-controlled, efficacy trial of a monocomponent pertussis ...
Trollfors, B., Lagergård, T., Gunnarsson, E., Taranger, J.   +3 more
openaire   +2 more sources