Results 31 to 40 of about 2,565 (197)

Pertactin-deficient isolates: evidence of increased circulation in Europe, 1998 to 2015. [PDF]

Eurosurveillance, 2019
IntroductionPertussis outbreaks have occurred in several industrialised countries using acellular pertussis vaccines (ACVs) since the 1990s.
Berbers, Guy, Markey, Kevin, Høgh, Silje Vermedal, Stefanelli, Paola, Wehlin, Lena, Vestrheim, Didrik, van Gent, Marjolein, Fry, Norman K., Mertsola, Jussi, Barkoff, Alex-Mikael, Pierard, Denis, Guillot, Sophie, Fry, Norman K, Dalby, Tine, Greve-Isdahl, Margrethe, Barkoff, Alex Mikael, Vestrheim, Didrik Frimann, He, Qiushui, Hoegh, Silje Vermedal, Ljungman, Margaretha   +19 more
core   +7 more sources

Pertactin-Negative and Filamentous Hemagglutinin-Negative Bordetella pertussis, Australia, 2013–2017

Emerging Infectious Diseases, 2019
During the 2008–2012 pertussis epidemic in Australia, pertactin (Prn)–negative Bordetella pertussis emerged. We analyzed 78 isolates from the 2013–2017 epidemic and documented continued expansion of Prn-negative ptxP3 B. pertussis strains.
Zheng Xu, Sophie Octavia, Laurence Don Wai Luu, Michael Payne, Verlaine Timms, Chin Yen Tay, Anthony D. Keil, Vitali Sintchenko, Nicole Guiso, Ruiting Lan   +9 more
doaj   +5 more sources

Crystallization and preliminary X-ray diffraction analysis of P30, the transmembrane domain of pertactin, an autotransporter fromBordetella pertussis

, 2007
P30, the 32 kDa transmembrane C-terminal domain of pertactin from Bordetella pertussis, is supposed to form a β-barrel inserted into the outer membrane for the translocation of the passenger domain.
Yanshi Zhu, Isobel Black, A.W. Roszak, Neil W. Isaacs   +3 more
openalex   +3 more sources

Structure of Bordetella pertussis virulence factor P.69 pertactin

Nature, 1996
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis.
Paul Emsley, Ian G. Charles, Fairweather, N.F., Fairweather, NF, Isaacs, NW, Neil W. Isaacs, Isaacs, N.W., Emsley, P, Emsley, P., Charles, I.G., Charles, IG, Neil F. Fairweather   +11 more
core   +3 more sources

Pertactin-Negative Variants of Bordetella pertussis in the United States [PDF]

New England Journal of Medicine, 2013
In 12 B. pertussis isolates from children in Philadelphia, 11 were negative for the pertactin antigen that is a component of the acellular vaccine. Such variants may reflect selection pressure from the vaccine and may reduce its effectiveness for preventing whooping cough.
Anne Marie Queenan, Pamela K. Cassiday, Alan T. Evangelista   +2 more
openalex   +4 more sources

Virulence of Pertactin-Negative Bordetella pertussis Isolates from Infants, France

Emerging Infectious Diseases, 2013
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants
Hélène Bodilis, Nicole Guiso
doaj   +2 more sources

Virulence of Pertactin-NegativeBordetella pertussisIsolates from Infants, France [PDF]

Emerging Infectious Diseases, 2013
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants
Hélène Bodilis, Nicole Guiso
openalex   +4 more sources

Antimicrobial Susceptibility of Pertactin-Producing and Pertactin-Deficient Strains of Bordetella pertussis From 2007 to 2014

Open Forum Infectious Diseases, 2015
Emily Souder, Jennifer Vodzak, Anne Marie Queenan, Sarah S. Long, Alan T. Evangelista   +4 more
openalex   +2 more sources

Rapid Identification of Bordetella pertussis Pertactin Gene Variants Using LightCycler Real-Time Polymerase Chain Reaction Combined with Melting Curve Analysis and Gel Electrophoresis

Emerging Infectious Diseases, 2001
Recently, eight allelic variants of the pertactin gene (prn1-8) have been characterized in Bordetella pertussis strains isolated in Europe and the United States.
Johanna Mäkinen, Matti K. Viljanen, Jussi Mertsola, Heikki Arvilommi, Qiushui He   +4 more
doaj   +2 more sources

Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis [PDF]

Emerging Infectious Diseases, 2021
Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Longhuan Ma, Amanda Caulfield, Kalyan K. Dewan, Eric T. Harvill   +3 more
doaj   +3 more sources