Results 51 to 60 of about 2,457 (145)

The Effect of Maternal Pertussis Vaccination on Neonatal Health Outcomes in the Dutch Pregnancy Drug Register

Birth Defects Research, Volume 118, Issue 4, April 2026.
ABSTRACT Background The currently high pertussis‐related morbidity and mortality among infants has led to increased international attention for pertussis vaccination during pregnancy. We studied the safety of maternal pertussis vaccination in the Netherlands with respect to neonatal health. Methods Data from the cohort the Dutch Pregnancy Drug Register
Petra J. Woestenberg, Veronique Y. F. Maas, Maud de Feijter, Leontine van Balveren, Maartje Conijn, Sanne Boetzkes, Anneke J. L. M. Passier, Agnes C. Kant   +7 more
wiley   +1 more source

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source

Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate‐to‐Severe Atopic Dermatitis

Allergy, Volume 80, Issue 8, Page 2213-2224, August 2025.
Data were included from adolescents with moderate‐to‐severe AD treated with the JAK1 inhibitor abrocitinib (200 mg/100 mg) across JADE clinical trials. Improvements in skin clearance (per EASI‐75) and itch (per PP‐NRS4) were maintained for up to 112 weeks with both abrocitinib doses.
Amy S. Paller, Lawrence F. Eichenfield, Alan D. Irvine, Carsten Flohr, Andreas Wollenberg, Sébastien Barbarot, Christine Bangert, Jonathan M. Spergel, Andrew Selfridge, Pinaki Biswas, Haiyun Fan, Justine Alderfer, Melissa Watkins, Herwig Koppensteiner   +13 more
wiley   +1 more source

Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Bordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune system, which makes them more susceptible to ...
Carolina Argondizo-Correia, Ana Kelly Sousa Rodrigues, Cyro Alves de Brito, Jacek Tabarkiewicz   +3 more
wiley   +1 more source

Acellular Pertussis Vaccines Induce CD8+ and CD4+ Regulatory T Cells That Suppress Protective Tissue‐Resident Memory CD4+ T Cells, in Part via IL‐10

European Journal of Immunology, Volume 55, Issue 7, July 2025.
The authors demonstrate that current aP vaccines induce IL‐10‐secreting CD4+ and CD8+ Treg cells that suppress IL‐17‐secreting respiratory tissue‐resident memory (TRM) cells, and thereby fail to prevent nasal infection with B. pertussis. Blocking IL‐10R in vivo or adding a novel adjuvant LP‐GMP and intranasal delivery reverses suppression and enhances ...
Caitlín Ní Chasaide, Pauline Schmitt, Béré K. Diallo, Lisa Borkner, Charlotte M. Leane, Seyed Davoud Jazayeri, Sreeram Udayan, Eoin O'Neill, Lucy M. Curham, Barry Moran, Mieszko M. Wilk, Kingston H. G. Mills   +11 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source

Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis

Emerging Infectious Diseases, 2021
Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Longhuan Ma, Amanda Caulfield, Kalyan K. Dewan, Eric T. Harvill   +3 more
doaj   +1 more source

Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species

Microbiology and Immunology, Volume 69, Issue 3, Page 133-147, March 2025.
ABSTRACT The Gram‐negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals. They share the BvgAS two‐component system, which regulates the phenotypic conversion between the virulent Bvg+ and avirulent Bvg– phases.
Natsuko Ota, Takashi Nishida, Daron M. Standley, Aalaa Alrahman Sherif, Satoshi Iwano, Dendi Krisna Nugraha, Toshiya Ueno, Yasuhiko Horiguchi   +7 more
wiley   +1 more source

Structure of Bordetella pertussis virulence factor P.69 pertactin

, 1996
A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis.
Paul Emsley, Ian G. Charles, Fairweather, N.F., Fairweather, NF, Isaacs, NW, Neil W. Isaacs, Isaacs, N.W., Emsley, P, Emsley, P., Charles, I.G., Charles, IG, Neil F. Fairweather, John Emsley   +12 more
core   +1 more source

New Data on Vaccine Antigen Deficient Bordetella pertussis Isolates

Vaccines, 2015
Evolution of Bordetella pertussis is driven by natural and vaccine pressures. Isolates circulating in regions with high vaccination coverage present multiple allelic and antigenic variations as compared to isolates collected before introduction of ...
Valérie Bouchez, Nicolas Hegerle, Francesco Strati, Elisabeth Njamkepo, Nicole Guiso   +4 more
doaj   +1 more source