Results 71 to 80 of about 2,565 (197)
Эпидемиология и вакцинопрофилактика, 2021 Relevance. The development of effective and safe vaccines for pertussis prevention remains an urgent public health challenge.Aim. To study the protective activity and safety of acellular pertussis vaccine (AcPV) containing a complex of protective ...
E. M. Zaitsev +4 more
doaj +1 more source
Allergy, Volume 80, Issue 8, Page 2213-2224, August 2025.Data were included from adolescents with moderate‐to‐severe AD treated with the JAK1 inhibitor abrocitinib (200 mg/100 mg) across JADE clinical trials. Improvements in skin clearance (per EASI‐75) and itch (per PP‐NRS4) were maintained for up to 112 weeks with both abrocitinib doses.
Amy S. Paller +13 more
wiley +1 more source
Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies
Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019 Bordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune system, which makes them more susceptible to ...
Carolina Argondizo-Correia +3 more
wiley +1 more source
Pertactin-Negative Bordetella pertussis Strains: Evidence for a Possible Selective Advantage [PDF]
Clinical Infectious Diseases, 2014 A recent increase in Bordetella pertussis without the pertactin protein, an acellular vaccine immunogen, has been reported in the United States. Determining whether pertactin-deficient (PRN(-)) B. pertussis is evading vaccine-induced immunity or altering the severity of illness is needed.We retrospectively assessed for associations between pertactin ...
Stacey W, Martin +17 more
openaire +2 more sources
European Journal of Immunology, Volume 55, Issue 7, July 2025.The authors demonstrate that current aP vaccines induce IL‐10‐secreting CD4+ and CD8+ Treg cells that suppress IL‐17‐secreting respiratory tissue‐resident memory (TRM) cells, and thereby fail to prevent nasal infection with B. pertussis. Blocking IL‐10R in vivo or adding a novel adjuvant LP‐GMP and intranasal delivery reverses suppression and enhances ...
Caitlín Ní Chasaide +11 more
wiley +1 more source
FEBS Open Bio, Volume 8, Issue 8, Page 1256-1266, August 2018., 2018 Filamentous hemagglutinins (FHA) of Bordetellae are produced by processing of the ~ 130‐kDa C‐terminal prodomains of their FhaB precursors by the subtilisin‐like protease SphB1. Despite near‐complete sequence conservation of the processed FhaB segments, the SphB1 cleavage sites of FhaB from B. pertussis and B.
David Jurnecka +3 more
wiley +1 more source
Bacterial Outer Membrane Vesicles: From Physics to Clinical
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou +7 more
wiley +1 more source
Outer membrane vesicles as platform vaccine technology
Biotechnology Journal, Volume 10, Issue 11, Page 1689-1706, November 2015., 2015 Abstract Outer membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐negative bacteria. They present a range of surface antigens in a native conformation and have natural properties like immunogenicity, self‐adjuvation and uptake by immune cells which make them attractive for application as vaccines against pathogenic bacteria.
Leo van der Pol +2 more
wiley +1 more source
Novel Genetic and Phenotypic Heterogeneity in Bordetella bronchiseptica Pertactin [PDF]
Infection and Immunity, 2001 ABSTRACT The Bordetella bronchiseptica outer membrane protein pertactin is believed to function as an adhesin and is an important protective immunogen. Previous sequence analysis of the pertactin gene identified two regions predicted to encode amino acid repeat motifs.
openaire +2 more sources
Role of the polymorphic region 1 of the Bordetella pertussis protein pertactin in immunity [PDF]
Microbiology, 2001 In several countries pertussis is re-emerging, despite a high vaccination coverage. It is suggested that antigenic divergence between Bordetella pertussis vaccine strains and circulating strains, in particular with respect to pertactin, has contributed to pertussis re-emergence.
King, AJrivm +5 more
openaire +3 more sources