Results 71 to 80 of about 3,408 (187)

Bordetella pertussis and Bordetella bronchiseptica filamentous hemagglutinins are processed at different sites

FEBS Open Bio, Volume 8, Issue 8, Page 1256-1266, August 2018., 2018
Filamentous hemagglutinins (FHA) of Bordetellae are produced by processing of the ~ 130‐kDa C‐terminal prodomains of their FhaB precursors by the subtilisin‐like protease SphB1. Despite near‐complete sequence conservation of the processed FhaB segments, the SphB1 cleavage sites of FhaB from B. pertussis and B.
David Jurnecka, Petr Man, Peter Sebo, Ladislav Bumba   +3 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles: From Physics to Clinical

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
A review of an introduction to the mechanisms of formation of OMVs, their action on bacteria and relationship to disease, vaccines, biomonitoring, drug delivery and regenerative medicine in the clinic. ABSTRACT Bacterial outer membrane vesicles (OMVs) are nanoscale vesicular structures naturally produced by Gram‐negative bacteria during growth.
Jun Zhou, Shuang Zou, Derong Dai, Liqing He, Xingyu Mou, Ninglin Zhao, Hong Li, Rui Bao   +7 more
wiley   +1 more source

Outer membrane vesicles as platform vaccine technology

Biotechnology Journal, Volume 10, Issue 11, Page 1689-1706, November 2015., 2015
Abstract Outer membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐negative bacteria. They present a range of surface antigens in a native conformation and have natural properties like immunogenicity, self‐adjuvation and uptake by immune cells which make them attractive for application as vaccines against pathogenic bacteria.
Leo van der Pol, Michiel Stork, Peter van der Ley   +2 more
wiley   +1 more source

Novel Genetic and Phenotypic Heterogeneity in Bordetella bronchiseptica Pertactin [PDF]

Infection and Immunity, 2001
ABSTRACT The Bordetella bronchiseptica outer membrane protein pertactin is believed to function as an adhesin and is an important protective immunogen. Previous sequence analysis of the pertactin gene identified two regions predicted to encode amino acid repeat motifs.
openaire   +2 more sources

Role of the Bordetella pertussis P.69/pertactin protein and the P.69/pertactin RGD motif in the adherence to and invasion of mammalian cells [PDF]

Microbiology, 1996
The role of the Bordetella pertussis P.69/pertactin protein in mammalian cell adhesion and invasion was investigated. Salmonella strains expressing surface-associated P.69/pertactin from a chromosomally located prn gene were significantly more invasive than isogenic parental strains. This effect was most pronounced in the poorly invasive, semi-rough S.
P, Everest, J, Li, G, Douce, I, Charles, J, De Azavedo, S, Chatfield, G, Dougan, M, Roberts   +7 more
openaire   +2 more sources

Epidemiology of pertussis in two Ibero-American countries with different vaccination policies: lessons derived from different surveillance systems [PDF]

, 2017
Background Pertussis is a re-emerging disease worldwide despite its high vaccination coverage. European and Latin-American countries have used different surveillance and vaccination policies against pertussis. We compared the epidemiology of this disease
Brache, Altagracia, Caylà i Buqueras, Joan A., Domínguez García, Àngela, Garib, Zacarías, Grullón, Patricia, Masa Calles, Josefa, Santiago, Sandy L., Solano, Rubén   +7 more
core   +1 more source

Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species

Microbiology and Immunology, Volume 69, Issue 3, Page 133-147, March 2025.
ABSTRACT The Gram‐negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals. They share the BvgAS two‐component system, which regulates the phenotypic conversion between the virulent Bvg+ and avirulent Bvg– phases.
Natsuko Ota, Takashi Nishida, Daron M. Standley, Aalaa Alrahman Sherif, Satoshi Iwano, Dendi Krisna Nugraha, Toshiya Ueno, Yasuhiko Horiguchi   +7 more
wiley   +1 more source

Flow Cytometric Assessment of Pertactin- and Tetanus Toxoid-Specific B-Cell Kinetics After Tdap Booster Vaccination in Healthy Adults

Vaccines
Background: Despite its high vaccination coverage, pertussis remains a public health concern due to waning vaccine-induced immunity and the emergence of pertactin (Prn)-negative strains.
Mirjam J. Esser, Annieck M. Diks, Liesbeth E. M. Oosten, Rick J. Groenland, Bas de Mooij, Cristina Teodosio, Gertjan J. A. Driessen, Jacques J. M. van Dongen, Magdalena A. Berkowska   +8 more
doaj   +1 more source

New Data on Vaccine Antigen Deficient Bordetella pertussis Isolates

Vaccines, 2015
Evolution of Bordetella pertussis is driven by natural and vaccine pressures. Isolates circulating in regions with high vaccination coverage present multiple allelic and antigenic variations as compared to isolates collected before introduction of ...
Valérie Bouchez, Nicolas Hegerle, Francesco Strati, Elisabeth Njamkepo, Nicole Guiso   +4 more
doaj   +1 more source

Adult Vaccine Coadministration Is Safe, Effective, and Acceptable: Results of a Survey of the Literature

Influenza and Other Respiratory Viruses, Volume 19, Issue 3, March 2025.
ABSTRACT Background Coadministration of vaccines in children is a long‐standing practice that has proven to be safe and effective in improving the efficiency of vaccine administration, thereby increasing immunization coverage rates. As the number of vaccines routinely recommended for adults increases, and with limited opportunities for adults to have ...
Litjen Tan, Dana Trevas, Ann R. Falsey
wiley   +1 more source