Results 71 to 80 of about 2,457 (145)

Immunogenicity and protective efficacy of a newly developed tri-component diphtheria, tetanus, and acellular pertussis vaccine in a murine model

Journal of Microbiology, Immunology and Infection, 2018
Background/Purpose: Although assessing the immunogenicity and protective efficacy of acellular pertussis (aP) vaccines via murine model studies faces limitations, preliminary assessments have been achieved by evaluating respiratory challenge and humoral ...
Dong Ho Huh, Seung Beom Han, Hye Jo Shin, Dong Ho Ahn, Gi Sub Choi, Kyu Ri Kang, Bo Ram Kim, Jin Han Kang   +7 more
doaj   +1 more source

Genomic Survey of Bordetella pertussis Diversity, United States, 2000–2013

Emerging Infectious Diseases, 2019
We characterized 170 complete genome assemblies from clinical Bordetella pertussis isolates representing geographic and temporal diversity in the United States. These data capture genotypic shifts, including increased pertactin deficiency, occurring amid
Michael R. Weigand, Margaret M. Williams, Yanhui Peng, Dane Kania, Lucia C. Pawloski, Maria L. Tondella   +5 more
doaj   +1 more source

Crucial role of antibodies to pertactin in Bordetella pertussis immunity [PDF]

, 2019
Pertussis, a serious infectious disease of the respiratory tract caused by Bordetella pertussis, is reemerging in vaccinated populations. Efforts to curtail this disease are hampered by limited insight into the basis of protective immunity ...
Rodríguez, María Eugenia, Mooi, Frits R., De Winkel, Jan G. J. van, Hellwig, Sandra M. M., Berbers, Guy A. M., Winkel, Jan G. J. van de   +5 more
core  

Humoral immunity to adhesins and toxins of the pertussis pathogen in mice immunized with experimental acellular pertussis vaccines from biofilm and planktonic cultures of Bordetella pertussis

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Whooping cough remains an urgent health problem worldwide, including in countries with high vaccination rates, where, since the 1990s, there has been an increase in the incidence of whooping cough, an increase in the severity of the disease
Evgeny M. Zaitsev, Marina V. Britsina, Maria N. Ozerеtskovskaya, Anton E. Zaitsev   +3 more
doaj   +1 more source

Prevention of aggregate formation through mechanism analysis in refolding of recombinant pertactin from Escherichia coli

, 2017
Production of natural pertactin for pharmaceutical use is limited by its low abundance. In this study, recombinant pertactin was highly expressed in the form of inclusion bodies in E. coll.
Zenglan Li, Zhiguo Su, Li, Xiunan, Ma, Guanghui, Luo, Jim, Su, Zhiguo, Guanghui Ma, Li, Zenglan, Chun Zhang, Yongdong Liu, Zhang, Chun, Yan Zhang, Zhang, Yan, Jian Luo, Liu, Yongdong, Xiunan Li   +15 more
core   +1 more source

Expression of P.69/pertactin from Bordetella pertussis in a baculovirus/insect cell expression system: protective properties of the recombinant protein.

, 1993
The surface antigen P.69/pertactin of Bordetella pertussis has been expressed using the polyhedron promoter of baculovirus in cultured insect cells. Either full-length or truncated prn DNA was used to express P.69 pertactin.
Roberts, M, Peakman, TC, Rodgers, B, Fairweather, N, Charles, I, Dougan, G, Chubb, A, Musgrave, S   +7 more
core   +1 more source

Prevalence and characterization of pertactin deficient Bordetella pertussis strains in Brazil, a whole-cell vaccine country

, 2021
Many countries have reported antigenic divergence among circulating Bordetella pertussis strains, mainly in those countries which introduced the acellular pertussis (aP) vaccine. This phenomenon can be seen, for example, with the recent rise of pertactin
Carlos Henrique Camargo, Ricardo Polatto, Juliana Cristina Pereira, Rosangela Siqueira de Oliveira, Daniela Leite, Lourdes Rehder de Andrade Vaz de Lima, Lucia Pawloski, Maria Lucia Tondella, Suely Sanae Kashino, Luciano Moura Martins   +9 more
core   +1 more source

Randomized clinical trial of the safety and immunogenicity of the Tdap vaccine in pregnant Mexican women

Human Vaccines & Immunotherapeutics, 2017
Immunization with the tetanus, diphtheria, and pertussis (Tdap) vaccine raises controversies on immunogenicity and possible antibody interference. We performed an experimental, double-blind, parallel group controlled clinical trial to evaluate the safety
Jesús Zacarías Villarreal Pérez, José Manuel Ramírez Aranda, Manuel de la O Cavazos, Michelle de J. Zamudio Osuna, José Perales Dávila, María Romelia Ballesteros Elizondo, Marco Vinicio Gómez Meza, Francisco Javier García Elizondo, Azucena M. Rodríguez González   +8 more
doaj   +1 more source

Adaptation of Bordetella pertussis to Vaccination: A Cause for Its Reemergence?

Emerging Infectious Diseases, 2001
In The Netherlands, as in many other western countries, pertussis vaccines have been used extensively for more than 40 years. Therefore, it is conceivable that vaccine-induced immunity has affected the evolution of B. pertussis.
Frits R. Mooi, Inge H. M. van Loo, Audrey King   +2 more
doaj   +1 more source

UPGMA Tree Based on the Analysis of the Pertactin Gene of Bordetella Isolates Used in the MLST Analysis

, 2013
The DNA segment coding for the extracellular domain of pertactin (P.69) was used for analysis, with the exclusion of the repeat regions 1 and 2. Bootstrap values are shown for the nodes separating the complexes and are based on 500 bootstrap replicates ...
Leo M Schouls (274878), Dimitri A Diavatopoulos (274876), Craig A Cummings (274877), Mary M Brinig (274879), David A Relman (31695), Frits R Mooi (83484)   +5 more
core   +1 more source