Results 81 to 90 of about 2,565 (197)

Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species

Microbiology and Immunology, Volume 69, Issue 3, Page 133-147, March 2025.
ABSTRACT The Gram‐negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals. They share the BvgAS two‐component system, which regulates the phenotypic conversion between the virulent Bvg+ and avirulent Bvg– phases.
Natsuko Ota, Takashi Nishida, Daron M. Standley, Aalaa Alrahman Sherif, Satoshi Iwano, Dendi Krisna Nugraha, Toshiya Ueno, Yasuhiko Horiguchi   +7 more
wiley   +1 more source

Prevalence and Molecular Characterization of Pertactin-Deficient Bordetella pertussis in the United States [PDF]

Clinical and Vaccine Immunology, 2013
ABSTRACTPertussis has shown a striking resurgence in the United States, with a return to record numbers of reported cases as last observed in the 1950s.Bordetella pertussisisolates lacking pertactin, a key antigen component of the acellular pertussis vaccine, have been observed, suggesting thatB.
L C, Pawloski, A M, Queenan, P K, Cassiday, A S, Lynch, M J, Harrison, W, Shang, M M, Williams, K E, Bowden, B, Burgos-Rivera, X, Qin, N, Messonnier, M L, Tondella   +11 more
openaire   +2 more sources

Adult Vaccine Coadministration Is Safe, Effective, and Acceptable: Results of a Survey of the Literature

Influenza and Other Respiratory Viruses, Volume 19, Issue 3, March 2025.
ABSTRACT Background Coadministration of vaccines in children is a long‐standing practice that has proven to be safe and effective in improving the efficiency of vaccine administration, thereby increasing immunization coverage rates. As the number of vaccines routinely recommended for adults increases, and with limited opportunities for adults to have ...
Litjen Tan, Dana Trevas, Ann R. Falsey
wiley   +1 more source

Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Antibodies that activate the complement system are essential in the immune defense against harmful bacteria and might present promising therapeutic strategies. The binding of C1q to surface‐bound antibodies initiates the classical complement pathway. It is influenced by factors beyond just the antibody isotype including the antibody's affinity for its ...
Nathan Aymerich, Luca J. Schlotheuber, Olivia T. M. Bucheli, Kevin Portmann, Jean Baudry, Klaus Eyer   +5 more
wiley   +1 more source

New Data on Vaccine Antigen Deficient Bordetella pertussis Isolates

Vaccines, 2015
Evolution of Bordetella pertussis is driven by natural and vaccine pressures. Isolates circulating in regions with high vaccination coverage present multiple allelic and antigenic variations as compared to isolates collected before introduction of ...
Valérie Bouchez, Nicolas Hegerle, Francesco Strati, Elisabeth Njamkepo, Nicole Guiso   +4 more
doaj   +1 more source

Nonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models

Journal of Applied Toxicology, Volume 44, Issue 11, Page 1689-1699, November 2024.
Abstract The (diphtheria, tetanus, and pertussis [acellular, component] [DTacP]) vaccine is a combined vaccine designed to prevent three potentially fatal diseases including pertussis, tetanus, and diphtheria in both children and adults. We utilized advanced technology to develop a novel DTacP vaccine that was previously unavailable in China.
Shihui Li, Hui Fu, Shouzhi Yu, Yuxiu Zhao, Ting Liu, Ling Wang, Na Zhang, Wei Wang, Baifeng Yang, Peng He, Yancen Guo, Shaoting Qiu, Yuntao Zhang   +12 more
wiley   +1 more source

How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrophobic content typical of foldable proteins, behave nearly as self‐avoiding random walks (SARWs) under physiological conditions.
Michael C. Baxa, Xiaoxuan Lin, Cedrick D. Mukinay, Srinivas Chakravarthy, Joseph R. Sachleben, Sarah Antilla, Nina Hartrampf, Joshua A. Riback, Isabelle A. Gagnon, Bradley L. Pentelute, Patricia L. Clark, Tobin R. Sosnick   +11 more
wiley   +1 more source

Analysis of BvgA Activation of the Pertactin Gene Promoter in Bordetella pertussis [PDF]

Journal of Bacteriology, 1999
ABSTRACT Bordetella pertussis , the causative agent of whooping cough, regulates expression of its virulence factors via a two-component signal transduction system encoded by the bvg regulatory locus.
S M, Kinnear, P E, Boucher, S, Stibitz, N H, Carbonetti   +3 more
openaire   +2 more sources

RpoN (sigma factor 54) contributes to bacterial fitness during tracheal colonization of Bordetella bronchiseptica

Microbiology and Immunology, Volume 68, Issue 2, Page 36-46, February 2024.
Abstract The Gram‐negative pathogenic bacterium Bordetella bronchiseptica is a respiratory pathogen closely related to Bordetella pertussis, the causative agent of whooping cough. Despite sharing homologous virulence factors, B. bronchiseptica infects a broad range of mammalian hosts, including some experimental animals, whereas B.
Xingyan Ma, Dendi K. Nugraha, Yukihiro Hiramatsu, Yasuhiko Horiguchi   +3 more
wiley   +1 more source

Dynamics and Energy Contributions for Transport of Pertactin through an Aerolysin Nanopore [PDF]

Biophysical Journal, 2015
Autotransporters are a large family of extracellular monomeric virulence proteins from Gram-negative bacteria. Despite their simplicity, many aspects of the autotransporter secretion mechanism remain unclear. We are using pertactin, an archetypical autotransporter from Bordetella pertussis, as a model for secretion studies.
Cressiot, Benjamin, Braselmann, Esther, Oukhaled, Abdelghani, Pelta, Juan, Clark, Patricia L.   +4 more
openaire   +1 more source