Results 81 to 90 of about 3,408 (187)

Construction and validation of a first-generation Bordetella bronchiseptica long-oligonucleotide microarray by transcriptional profiling the Bvg regulon [PDF]

, 2007
Background Bordetella bronchiseptica is a bacterial respiratory pathogen that infects a broad range of mammals, causing chronic and often subclinical infections.
Tracy L Nicholson
core   +1 more source

Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Antibodies that activate the complement system are essential in the immune defense against harmful bacteria and might present promising therapeutic strategies. The binding of C1q to surface‐bound antibodies initiates the classical complement pathway. It is influenced by factors beyond just the antibody isotype including the antibody's affinity for its ...
Nathan Aymerich, Luca J. Schlotheuber, Olivia T. M. Bucheli, Kevin Portmann, Jean Baudry, Klaus Eyer   +5 more
wiley   +1 more source

Complete Genome Sequences of Bordetella pertussis Isolates with Novel Pertactin-Deficient Deletions [PDF]

Genome Announcements, 2017
ABSTRACT Clinical isolates of the respiratory pathogen Bordetella pertussis in the United States have become predominantly deficient for the acellular vaccine immunogen pertactin through various independent mutations. Here, we report the complete genome sequences for four B. pertussis
Michael R. Weigand, Yanhui Peng, Pamela K. Cassiday, Vladimir N. Loparev, Taccara Johnson, Phalasy Juieng, Elizabeth J. Nazarian, Keeley Weening, M. Lucia Tondella, Margaret M. Williams   +9 more
openaire   +2 more sources

Prevalence and characterization of pertactin deficient Bordetella pertussis strains in Brazil, a whole-cell vaccine country

Vaccine: X, 2021
Many countries have reported antigenic divergence among circulating Bordetella pertussis strains, mainly in those countries which introduced the acellular pertussis (aP) vaccine. This phenomenon can be seen, for example, with the recent rise of pertactin
Daniela Leite, Carlos Henrique Camargo, Suely Sanae Kashino, Ricardo Polatto, Luciano Moura Martins, Juliana Cristina Pereira, Lucia Pawloski, Maria Lucia Tondella, Rosangela Siqueira de Oliveira, Lourdes Rehder de Andrade Vaz de Lima   +9 more
doaj   +1 more source

Nonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models

Journal of Applied Toxicology, Volume 44, Issue 11, Page 1689-1699, November 2024.
Abstract The (diphtheria, tetanus, and pertussis [acellular, component] [DTacP]) vaccine is a combined vaccine designed to prevent three potentially fatal diseases including pertussis, tetanus, and diphtheria in both children and adults. We utilized advanced technology to develop a novel DTacP vaccine that was previously unavailable in China.
Shihui Li, Hui Fu, Shouzhi Yu, Yuxiu Zhao, Ting Liu, Ling Wang, Na Zhang, Wei Wang, Baifeng Yang, Peng He, Yancen Guo, Shaoting Qiu, Yuntao Zhang   +12 more
wiley   +1 more source

Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

mBio, 2022
Bordetella produces an array of virulence factors, including the adenylate cyclase toxin (ACT), which is essential, immunogenic in humans, and highly conserved.
Andrea M. DiVenere, Dzifa Amengor, Rui P. Silva, Jory A. Goldsmith, Jason S. McLellan, Jennifer A. Maynard   +5 more
doaj   +1 more source

Serologic Response and Antibody-Titer Decay in Adults with Pertussis [PDF]

, 2017
Pertussis is a frequent and significant illness in adults. Because acellular pertussis vaccines for use in adolescents and adults have now been developed, it is important to compare serologic responses in adults after infection with serologic responses ...
Cherry, James D., Heininger, Ulrich, Stehr, Klemens   +2 more
core  

Immunogenicity of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine compared to standard-dose diphtheria, tetanus, acellular pertussis when used as a pre-school booster in UK children : a 5-year follow-up of a randomised controlled study [PDF]

, 2015
This serological follow up study assessed the kinetics of antibody response in children who previously participated in a single centre, open-label, randomised controlled trial of low-dose compared to standard-dose diphtheria booster preschool ...
Baudin, M., Fiquet, A., John, T., Kitchin, N., McCarthy, Noel D., Pollard, A. J., Richard, P., Voysey, M., Yu, L. M.   +8 more
core   +1 more source

How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrophobic content typical of foldable proteins, behave nearly as self‐avoiding random walks (SARWs) under physiological conditions.
Michael C. Baxa, Xiaoxuan Lin, Cedrick D. Mukinay, Srinivas Chakravarthy, Joseph R. Sachleben, Sarah Antilla, Nina Hartrampf, Joshua A. Riback, Isabelle A. Gagnon, Bradley L. Pentelute, Patricia L. Clark, Tobin R. Sosnick   +11 more
wiley   +1 more source

Rapid Identification of Bordetella pertussis Pertactin Gene Variants Using LightCycler Real-Time Polymerase Chain Reaction Combined with Melting Curve Analysis and Gel Electrophoresis

Emerging Infectious Diseases, 2001
Recently, eight allelic variants of the pertactin gene (prn1-8) have been characterized in Bordetella pertussis strains isolated in Europe and the United States.
Johanna Mäkinen, Matti K. Viljanen, Jussi Mertsola, Heikki Arvilommi, Qiushui He   +4 more
doaj   +1 more source