Genomic Survey of Bordetella pertussis Diversity, United States, 2000–2013
Emerging Infectious Diseases, 2019 We characterized 170 complete genome assemblies from clinical Bordetella pertussis isolates representing geographic and temporal diversity in the United States. These data capture genotypic shifts, including increased pertactin deficiency, occurring amid
Michael R. Weigand +5 more
doaj +1 more source
Dissecting and reprogramming the folding and assembly of tandem-repeat proteins. [PDF]
, 2015 Studying protein folding and protein design in globular proteins presents significant challenges because of the two related features, topological complexity and co-operativity.
Itzhaki, Laura S +4 more
core +2 more sources
Prevalence and Molecular Characterization of Pertactin-Deficient Bordetella pertussis in the United States [PDF]
Clinical and Vaccine Immunology, 2013 ABSTRACTPertussis has shown a striking resurgence in the United States, with a return to record numbers of reported cases as last observed in the 1950s.Bordetella pertussisisolates lacking pertactin, a key antigen component of the acellular pertussis vaccine, have been observed, suggesting thatB.
L C, Pawloski +11 more
openaire +2 more sources
Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Whooping cough remains an urgent health problem worldwide, including in countries with high vaccination rates, where, since the 1990s, there has been an increase in the incidence of whooping cough, an increase in the severity of the disease
Evgeny M. Zaitsev +3 more
doaj +1 more source
Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines [PDF]
, 2018 Mimicry of the binding interface of antibody-antigen interactions using peptide-based modulators (i.e. epitope mimics) has promising applications for vaccine design.
Dunlop, James I. +5 more
core +2 more sources
Capsule shields the function of short bacterial adhesins [PDF]
, 2004 Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding.
Schembri, Mark A. +2 more
core +1 more source
A structurally informed autotransporter platform for efficient heterologous protein secretion and display. [PDF]
, 2012 Background The self-sufficient autotransporter (AT) pathway, ubiquitous in Gram-negative bacteria, combines a relatively simple protein secretion mechanism with a high transport capacity.
Andersen Peter +9 more
core +4 more sources
Coadministration of a 9-Valent Human Papillomavirus Vaccine With Meningococcal and Tdap Vaccines [PDF]
, 2015 BACKGROUND: This study in 11- to 15-year-old boys and girls compared the immunogenicity and safety of GARDASIL 9 (9-valent human papillomavirus [9vHPV] vaccine) administered either concomitantly or nonconcomitantly with 2 vaccines routinely administered ...
Caldwell, Nicole +12 more
core +1 more source
Bordetella pertussisand pertactin-deficient clinical isolates: lessons for pertussis vaccines
Expert Review of Vaccines, 2014 Bordetella pertussis causes whooping cough in humans, a highly transmissible respiratory disease life threatening for unvaccinated infants. Vaccination strategies were thus introduced worldwide with great success in developed countries reaching high vaccine coverage with efficacious vaccines.
Nicolas, Hegerle, Nicole, Guiso
openaire +2 more sources
On Technological and Immunological Benefits of Multivalent Single-Injection Microsphere Vaccines [PDF]
, 2018 Purpose. With the aim of developing multivalent vaccines for single-injection, we examined the feasibility of combining antigens in biodegradable microspheres.
Boehm, Gérard +9 more
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