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Revisiting Whooping Cough: Global Drivers and Implications of Pertussis Resurgence in the Acellular Vaccine Era [PDF]

open access: yesVaccines
Background: Whooping cough caused by Bordetella pertussis is re-emerging despite high vaccination coverage, with rising incidence in adolescents and adults in the acellular vaccine (aP) era.
Siheng Zhang, Yan Xu, Ying Xiao
doaj   +2 more sources

Exploring the cause of the pertussis resurgence in England following the COVID-19 pandemic: a mathematical modelling study [PDF]

open access: yesBMC Infectious Diseases
Background In 2024 England, in common with many other countries, experienced a pertussis resurgence the cause of which is unclear. We used a pertussis transmission model, previously developed to investigate the cause of the pertussis resurgence in ...
Yoon Hong Choi   +2 more
doaj   +2 more sources

Comparing the pertussis antibody levels of healthy children immunized with four doses of DTap-IPV/Hib (Pentaxim) combination vaccine and DTaP vaccine in Quzhou, China

open access: yesFrontiers in Immunology, 2023
Despite the high coverage of pertussis vaccines in high-income countries, pertussis resurgence has been reported in recent years, and has stimulated interest in the effects of vaccines and vaccination strategies. Immunoglobulin G (IgG) antibodies against
Zhiying Yin   +8 more
doaj   +1 more source

Pertussis vaccines and the role of Bordetella pertussis lipooligosaccharide in the immune response to pertussis infection and vaccination

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2021
Some scientific publications contain data suggesting the “return” or “resurgence” of pertussis. Prevention and elimination of pertussis can only be achieved by extensive immunisation of susceptible populations with a highly effective vaccine.
I. A. Alekseeva   +2 more
doaj   +1 more source

Age and Primary Vaccination Background Influence the Plasma Cell Response to Pertussis Booster Vaccination

open access: yesVaccines, 2022
Pertussis is a vaccine-preventable disease caused by the bacterium Bordetella pertussis. Over the past years, the incidence and mortality of pertussis increased significantly. A possible cause is the switch from whole-cell to acellular pertussis vaccines,
Annieck M. Diks   +12 more
doaj   +1 more source

Lessons from a mature acellular pertussis vaccination program and strategies to overcome suboptimal vaccine effectiveness

open access: yesExpert Review of Vaccines, 2022
Introduction Despite high vaccination coverage among children and adolescents, pertussis remains a public health problem, with large outbreaks occurring periodically in the US and other developed countries.Areas covered We examine lessons learned more ...
Ousseny Zerbo   +2 more
doaj   +1 more source

Bacterial outer membrane vesicles and vaccine applications [PDF]

open access: yes, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo   +10 more
core   +6 more sources

An infant who suffered seizures many times after pentavalent vaccination: A case report

open access: yesİstanbul Kuzey Klinikleri, 2020
Although rare, serious adverse effects may be seen after vaccination. Especially, the whole-cell pertussis vaccine has been held responsible for neurological side effects, as the most important problem in vaccination.
Meryem Erat Nergiz   +4 more
doaj   +1 more source

Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis

open access: yesEmerging Infectious Diseases, 2021
Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Longhuan Ma   +3 more
doaj   +1 more source

Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination

open access: yesScientific Reports, 2022
Infection is the most common cause of mortality early in life, yet the broad potential of immunization is not fully realized in this vulnerable population. Most vaccines are administered during infancy and childhood, but in some cases the full benefit of
David J. Dowling   +16 more
doaj   +1 more source

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