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Acellular Pertussis Vaccine Components: Today and Tomorrow

Vaccines, 2020
Pertussis is a highly communicable acute respiratory infection caused by Bordetella pertussis. Immunity is not lifelong after natural infection or vaccination. Pertussis outbreaks occur cyclically worldwide and effective vaccination strategies are needed
Kalyan K. Dewan, Bodo Linz, Susan E. DeRocco, Eric T. Harvill   +3 more
doaj   +4 more sources

Proteomic Analysis of Membrane Blebs of Brucella abortus 2308 and RB51 and Their Evaluation as an Acellular Vaccine. [PDF]

Front Microbiol, 2019
Membrane blebs are released from Gram-negative bacteria, however, little is known about Brucella blebs. This work pursued two objectives, the first was to determine and identify the proteins in the membrane blebs by proteomics and in silico analysis. The
Araiza-Villanueva M, Avila-Calderón ED, Flores-Romo L, Calderón-Amador J, Sriranganathan N, Qublan HA, Witonsky S, Aguilera-Arreola MG, Ruiz-Palma MDS, Ruiz EA, Suárez-Güemes F, Gómez-Lunar Z, Contreras-Rodríguez A.   +12 more
europepmc   +2 more sources

Revisiting Whooping Cough: Global Drivers and Implications of Pertussis Resurgence in the Acellular Vaccine Era [PDF]

Vaccines
Background: Whooping cough caused by Bordetella pertussis is re-emerging despite high vaccination coverage, with rising incidence in adolescents and adults in the acellular vaccine (aP) era.
Siheng Zhang, Yan Xu, Ying Xiao
doaj   +2 more sources

Immunogenicity and safety of primary three-dose series with diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed in 3 months infants [PDF]

Frontiers in Immunology
This study aimed to evaluate the safety and immunogenicity of a novel diphtheria, tetanus, and pertussis (acellular, three components) combined vaccine, adsorbed (DTcP) vaccine compared to the existing co-purified DTaP vaccine in China. In this partially
Wei Zhang, Chen Wei, Chen Wei, Haitao Huang, Xue Wang, Zhiqiang Xie, Yan Wu, Yan Wu, Feiyu Wang, Lili Huang, Xuewen Wang, Xiuwen Sui, Peng Wan, Zhe Chao, Zhe Chao, Jinbo Gou, Bozhi Shi, Bozhi Shi, Jia Liu, Tao Zhu, Liyong Yuan, Liyong Yuan, Yanxia Wang   +22 more
doaj   +2 more sources

Preclinical study on an adsorbed acellular diphtheria- tetanus-pertussis (reduced-dose) combined vaccine: evaluation of reproductive safety and immunogenicity [PDF]

Frontiers in Immunology
IntroductionThe diphtheria, tetanus, and acellular pertussis combined vaccine (DTaP) is a trivalent formulation containing acellular pertussis antigens, diphtheria toxoid, and tetanus toxoid, and provides simultaneous protection against pertussis ...
Han Chu, Wenlu Kong, Qin Gu, Qin Gu, Qin Gu, Qin Gu, Yan Ma, Yan Ma, Yan Ma, Yan Ma, Lukui Cai, Lukui Cai, Lukui Cai, Lukui Cai, Jingyan Li, Jingyan Li, Jingyan Li, Jingyan Li, Xiaoyu Wang, Xiaoyu Wang, Xiaoyu Wang, Qiuyan Ji, Qiuyan Ji, Qiuyan Ji, Jiana Wen, Jiana Wen, Jiana Wen, Na Gao, Na Gao, Na Gao, Na Gao, Guang Ji, Guang Ji, Guang Ji, Wenzhu Hu, Wenzhu Hu, Wenzhu Hu, Ting Zhao, Ting Zhao, Ting Zhao, Ting Zhao, Ling Ping, Ling Ping, Ling Ping, Ling Ping, Yuting Fu, Yuting Fu, Yuting Fu, Ying Li, Tiannan Gong, Yingfu Jin, Yufan Yang, Yixian Fu, Xinhua Qin, Huimei Zheng, Jingsi Yang, Jingsi Yang, Jingsi Yang, Jingsi Yang, Jiangli Liang, Jiangli Liang, Jiangli Liang, Jiangli Liang   +62 more
doaj   +2 more sources

Bordetella pertussis Infection: From Immune Pathogenesis to Next-Generation Vaccines [PDF]

Vaccines
Pertussis is a highly contagious respiratory infection caused by Bordetella pertussis and remains a persistent global health challenge despite widespread vaccination. This review aims to analyze the immune pathogenesis of B.
Vasiliki E. Georgakopoulou, Vassiliki C. Pitiriga   +1 more
doaj   +2 more sources

Immunological Distinctions between Acellular and Whole-Cell Pertussis Immunizations of Baboons Persist for at Least One Year after Acellular Vaccine Boosting [PDF]

Vaccines, 2020
Lingyi Zheng
exaly   +2 more sources

Exploring the cause of the pertussis resurgence in England following the COVID-19 pandemic: a mathematical modelling study [PDF]

BMC Infectious Diseases
Background In 2024 England, in common with many other countries, experienced a pertussis resurgence the cause of which is unclear. We used a pertussis transmission model, previously developed to investigate the cause of the pertussis resurgence in ...
Yoon Hong Choi, Edwin van Leeuwen, Elizabeth Miller   +2 more
doaj   +2 more sources

Comparing the pertussis antibody levels of healthy children immunized with four doses of DTap-IPV/Hib (Pentaxim) combination vaccine and DTaP vaccine in Quzhou, China

Frontiers in Immunology, 2023
Despite the high coverage of pertussis vaccines in high-income countries, pertussis resurgence has been reported in recent years, and has stimulated interest in the effects of vaccines and vaccination strategies. Immunoglobulin G (IgG) antibodies against
Zhiying Yin, Zhiying Yin, Canjie Zheng, Quanjun Fang, Tingcui Wen, Shuangqing Wang, Junji Li, Xiaoying Gong, Ziling Xiang   +8 more
doaj   +1 more source

Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy

Medical Principles and Practice, 2022
Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis. Although most cases occur in developing countries, it is considered endemic globally.
Mohammad Alghounaim, Z. Alsaffar, Abdulla Alfraij, S. Bin-Hasan, Entesar Hussain   +4 more
semanticscholar   +1 more source