Results 61 to 70 of about 3,408 (187)

Conservation and global distribution of non-canonical antigens in enterotoxigenic Escherichia coli [PDF]

, 2019
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) cause significant diarrheal morbidity and mortality in children of resource-limited regions, warranting development of effective vaccine strategies.
Boxrud, Dave, Cebelinski, Elizabeth, Del Canto, Felipe, Fleckenstein, James M, Gómez-Duarte, Oscar G, Hazen, Tracy H, Kuhlmann, F. Matthew Matthew, Martin, John, Mitreva, Makedonka, Okhuysen, Pablo C, Pashos, Madeline, Qadri, Firdausi, Rasko, David A, Vickers, Tim J, Vidal, Roberto   +14 more
core   +2 more sources

The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]

, 2016
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie, Devos, Simon, Devreese, Bart   +2 more
core   +2 more sources

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source

Acellular pertussis vaccines and the role of pertactin and fimbriae

Expert Review of Vaccines, 2007
The introduction of acellular pertussis (Pa) vaccines in countries with a low uptake of whole-cell pertussis (Pw) vaccines has led to a dramatic reduction in pertussis disease. Diphtheria-tetanus-acellular pertussis (DTPa) vaccines have also ensured continued high level disease protection in these countries following the shift from Pw- to Pa-containing
Jan T, Poolman, Hans O, Hallander
openaire   +2 more sources

Pertactin-Negative Variants of Bordetella pertussis in the United States [PDF]

New England Journal of Medicine, 2013
In 12 B. pertussis isolates from children in Philadelphia, 11 were negative for the pertactin antigen that is a component of the acellular vaccine. Such variants may reflect selection pressure from the vaccine and may reduce its effectiveness for preventing whooping cough.
Anne Marie, Queenan, Pamela K, Cassiday, Alan, Evangelista   +2 more
openaire   +2 more sources

Integrated Efficacy and Safety Analysis of Abrocitinib in Adolescents With Moderate‐to‐Severe Atopic Dermatitis

Allergy, Volume 80, Issue 8, Page 2213-2224, August 2025.
Data were included from adolescents with moderate‐to‐severe AD treated with the JAK1 inhibitor abrocitinib (200 mg/100 mg) across JADE clinical trials. Improvements in skin clearance (per EASI‐75) and itch (per PP‐NRS4) were maintained for up to 112 weeks with both abrocitinib doses.
Amy S. Paller, Lawrence F. Eichenfield, Alan D. Irvine, Carsten Flohr, Andreas Wollenberg, Sébastien Barbarot, Christine Bangert, Jonathan M. Spergel, Andrew Selfridge, Pinaki Biswas, Haiyun Fan, Justine Alderfer, Melissa Watkins, Herwig Koppensteiner   +13 more
wiley   +1 more source

Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Bordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune system, which makes them more susceptible to ...
Carolina Argondizo-Correia, Ana Kelly Sousa Rodrigues, Cyro Alves de Brito, Jacek Tabarkiewicz   +3 more
wiley   +1 more source

Molecular aspects of Bordetella pertussis pathogenesis [PDF]

, 2010
The molecular mechanisms of Bordetella virulence are now well understood, and many virulence factors have been identified and characterized at the molecular level.
Camille Locht
core   +2 more sources

Structural basis for the role of Serine-Rich Repeat Proteins from Lactobacillus reuteri in gut microbe-host interactions [PDF]

, 2018
Lactobacillus reuteri, a Gram-positive bacterial species inhabiting the gastrointestinal tract of vertebrates displays remarkable host adaptation. Previous mutational analyses of rodent strain L.
A. Patrick Gunning, Bandara, Changjiang Dong, Charlotte Leclaire, Couvigny, Devon Kavanaugh, Dimitrios Latousakis, Donald A. MacKenzie, Garnett, Jesus Angulo, Muller, Nathalie Juge, Oguchi, Prabudiansyah, Saannya Sequeira, Samuel Walpole, Sundaresan, Tanja Šuligoj, Urano-Tashiro, William G. T. Willats   +19 more
core   +1 more source

Acellular Pertussis Vaccines Induce CD8+ and CD4+ Regulatory T Cells That Suppress Protective Tissue‐Resident Memory CD4+ T Cells, in Part via IL‐10

European Journal of Immunology, Volume 55, Issue 7, July 2025.
The authors demonstrate that current aP vaccines induce IL‐10‐secreting CD4+ and CD8+ Treg cells that suppress IL‐17‐secreting respiratory tissue‐resident memory (TRM) cells, and thereby fail to prevent nasal infection with B. pertussis. Blocking IL‐10R in vivo or adding a novel adjuvant LP‐GMP and intranasal delivery reverses suppression and enhances ...
Caitlín Ní Chasaide, Pauline Schmitt, Béré K. Diallo, Lisa Borkner, Charlotte M. Leane, Seyed Davoud Jazayeri, Sreeram Udayan, Eoin O'Neill, Lucy M. Curham, Barry Moran, Mieszko M. Wilk, Kingston H. G. Mills   +11 more
wiley   +1 more source