Results 61 to 70 of about 2,457 (145)

Adult Vaccine Coadministration Is Safe, Effective, and Acceptable: Results of a Survey of the Literature

Influenza and Other Respiratory Viruses, Volume 19, Issue 3, March 2025.
ABSTRACT Background Coadministration of vaccines in children is a long‐standing practice that has proven to be safe and effective in improving the efficiency of vaccine administration, thereby increasing immunization coverage rates. As the number of vaccines routinely recommended for adults increases, and with limited opportunities for adults to have ...
Litjen Tan, Dana Trevas, Ann R. Falsey
wiley   +1 more source

Complete Genome Sequences of Bordetella pertussis Isolates with Novel Pertactin-Deficient Deletions

, 2017
Clinical isolates of the respiratory pathogen Bordetella pertussis in the United States have become predominantly deficient for the acellular vaccine immunogen pertactin through various independent mutations.
Taccara Johnson, Elizabeth J. Nazarian, Michael R. Weigand, Vladimir N. Loparev, Pamela K. Cassiday, Phalasy Juieng, M. Lucia Tondella, Yanhui Peng, Keeley Weening, Margaret M. Williams   +9 more
core   +1 more source

Antibody density on bacteria regulates C1q recruitment by monoclonal IgG but not IgM

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Antibodies that activate the complement system are essential in the immune defense against harmful bacteria and might present promising therapeutic strategies. The binding of C1q to surface‐bound antibodies initiates the classical complement pathway. It is influenced by factors beyond just the antibody isotype including the antibody's affinity for its ...
Nathan Aymerich, Luca J. Schlotheuber, Olivia T. M. Bucheli, Kevin Portmann, Jean Baudry, Klaus Eyer   +5 more
wiley   +1 more source

Dynamics and Energy Contributions for Transport of Unfolded Pertactin through a Protein Nanopore

, 2015
To evaluate the physical parameters governing translocation of an unfolded protein across a lipid bilayer, we studied protein transport through aerolysin, a passive protein channel, at the single-molecule level.
Pelta, Juan, Elcock, Adrian H., Adrian H. Elcock, Abdelghani Oukhaled, Braselmann, Esther, Benjamin Cressiot, Oukhaled, Abdelghani, Adrian H. Elcock (252477), Juan Pelta (1297611), Abdelghani Oukhaled (1297608), Patricia L. Clark, Juan Pelta, Esther Braselmann (1526932), Esther Braselmann, Benjamin Cressiot (1526929), Clark, Patricia L., Cressiot, Benjamin, Patricia L. Clark (376323)   +17 more
core   +1 more source

Identification of linear B epitopes of pertactin of Bordetella pertussisinduced by immunization with whole and acellular vaccine [PDF]

, 2014
tPertussis is a serious infectious disease of the respiratory tract caused by the gram-negative bacteria Bor-detella pertussis. There has been a reemergence of this disease within the population of several countriesthat have well established vaccination ...
De Simone, Salvatore Giovanni, De-Simone, Salvatore G., De Simone, Salvatore G., Silva, Flavio R. da, Pego, Paloma Napoleão, da Silva, Flavio R., Napoleão-Pego, Paloma   +6 more
core   +1 more source

Nonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models

Journal of Applied Toxicology, Volume 44, Issue 11, Page 1689-1699, November 2024.
Abstract The (diphtheria, tetanus, and pertussis [acellular, component] [DTacP]) vaccine is a combined vaccine designed to prevent three potentially fatal diseases including pertussis, tetanus, and diphtheria in both children and adults. We utilized advanced technology to develop a novel DTacP vaccine that was previously unavailable in China.
Shihui Li, Hui Fu, Shouzhi Yu, Yuxiu Zhao, Ting Liu, Ling Wang, Na Zhang, Wei Wang, Baifeng Yang, Peng He, Yancen Guo, Shaoting Qiu, Yuntao Zhang   +12 more
wiley   +1 more source

How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins

Protein Science, Volume 33, Issue 5, May 2024.
Abstract Despite the generally accepted role of the hydrophobic effect as the driving force for folding, many intrinsically disordered proteins (IDPs), including those with hydrophobic content typical of foldable proteins, behave nearly as self‐avoiding random walks (SARWs) under physiological conditions.
Michael C. Baxa, Xiaoxuan Lin, Cedrick D. Mukinay, Srinivas Chakravarthy, Joseph R. Sachleben, Sarah Antilla, Nina Hartrampf, Joshua A. Riback, Isabelle A. Gagnon, Bradley L. Pentelute, Patricia L. Clark, Tobin R. Sosnick   +11 more
wiley   +1 more source

RpoN (sigma factor 54) contributes to bacterial fitness during tracheal colonization of Bordetella bronchiseptica

Microbiology and Immunology, Volume 68, Issue 2, Page 36-46, February 2024.
Abstract The Gram‐negative pathogenic bacterium Bordetella bronchiseptica is a respiratory pathogen closely related to Bordetella pertussis, the causative agent of whooping cough. Despite sharing homologous virulence factors, B. bronchiseptica infects a broad range of mammalian hosts, including some experimental animals, whereas B.
Xingyan Ma, Dendi K. Nugraha, Yukihiro Hiramatsu, Yasuhiko Horiguchi   +3 more
wiley   +1 more source

Selective ligand recognition by a diversity-generating retroelement variable protein.

PLoS Biology, 2008
Diversity-generating retroelements (DGRs) recognize novel ligands through massive protein sequence variation, a property shared uniquely with the adaptive immune response. Little is known about how recognition is achieved by DGR variable proteins.
Jason L Miller, Johanne Le Coq, Asher Hodes, Roman Barbalat, Jeff F Miller, Partho Ghosh   +5 more
doaj   +1 more source

Recombinant Bordetella pertussis pertactin (P69) from the yeast Pichia pastoris: high-level production and immunological properties.

, 1991
Acellular whooping cough vaccines are based on pertussis toxoid but their effectiveness may be increased by the addition of other Bordetella pertussis antigens. We expressed the immunogenic outer membrane protein pertactin (P69) from B. pertussis to high
Fairweather, NF, Ballantine, SP, Makoff, AJ, Romanos, MA, Rayment, FB, Beesley, KM, Dougan, G, Charles, IG, Clare, JJ   +8 more
core   +1 more source