Results 71 to 80 of about 166,888 (204)
Vaccine Research, 2015 Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the ...
F Sadeghpour Heravi +2 more
doaj
Dimerization of human PARP15 is required for NAD+ binding and automodification
The FEBS Journal, EarlyView.This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen +9 more
wiley +1 more source
mSphereThe adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes.
Carlos Espinosa-Vinals +6 more
doaj +1 more source
Internal Medicine Journal, EarlyView.Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley +15 more
wiley +1 more source
BMC Pediatrics, 2018 Background Vaccination is still one of the most important methods to control and prevent childhood infections including diphtheria and pertussis. This study evaluated the level of diphtheria (DT) and pertussis (PT)-related antibodies among children with ...
Qinghong Meng +7 more
doaj +1 more source
Acta Paediatrica, Volume 115, Issue 11, Page 2370-2379, November 2026.ABSTRACT Aim To provide an update paper on evidence of adverse events of concern following immunization (AEFI) with pertussis vaccines, focusing primarily on acellular (aP) vaccines. Methods Evidence was synthesised from epidemiological studies, systematic reviews over recent decades, expert interpretations in reviews from relevant research teams and ...
Lennart Nilsson, Jann Storsaeter
wiley +1 more source
Pertussis toxin is required for pertussis vaccine encephalopathy. [PDF]
Proceedings of the National Academy of Sciences, 1985 A mouse model for encephalopathy induced by pertussis immunization has been described; it has features that closely resemble some of the severe reactions, including seizures and a shock-like state leading to death, occasionally seen after administration of Bordetella pertussis (whooping cough) vaccine.
L, Steinman +7 more
openaire +2 more sources
, 2021 Serological diagnosis of pertussis is mainly based on anti-pertussis toxin (PT) IgG antibodies. Since PT is included in all acellular vaccines (ACV), serological assays do not differentiate antibodies induced by ACVs and infection.
Peter Sebo +5 more
core +1 more source
Iranian Journal of Microbiology, 2020 Background and Objectives: There are many pertussis outbreaks which is mainly due to the reduction in the immunity of acellular pertussis (aP) vaccines. Therefore, there is a crucial necessity to develop a new generation of pertussis vaccine.
Mohammad Sekhavati +3 more
doaj +1 more source
, 2017 Background: Pertussis infection can be severe in unvaccinated infants. A case-control study was conducted to investigate the potential role of breast-feeding in protecting young, unvaccinated infants from pertussis.
Carsetti Rita +17 more
core +1 more source