Results 71 to 80 of about 33,335 (199)

Characterization of new approaches to inhibit Pertussis toxin based on human peptides and cellular chaperone inhibitors [PDF]

Pertussis, also known as whooping cough, is a contagious respiratory disease, caused by a bacterial infection with Bordetella pertussis. Pertussis is characterized by paroxysmal coughing, which can lead to severe complications and even death, especially ...
Kling, Carolin
core   +1 more source

Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection

mSphere
Pertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP).
Karolína Škopová, Jana Holubová, Barbora Bočková, Eva Slivenecká, João Melo Santos de Barros, Ondřej Staněk, Peter Šebo   +6 more
doaj   +1 more source

Microbiological, Molecular Diagnosis and Antimicrobial Resistance of Bordetella bronchiseptica in the Equine Reproductive Tract in Brazil

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
First report of Bordetella bronchiseptica in the reproductive tract of Brazilian mares. Uterine lavage samples from mares with endometritis and infertility were positive by culture, PCR (237 bp flaA), sequencing and phylogenetic analysis. Isolates showed multidrug resistance, emphasizing the relevance of this pathogen in equine reproductive disorders ...
Samira Salim Mello Gallo, Maria de Lourdes Amaral Bernardino, Luiz Antonio Silveira da Motta Júnior, Francisco Carlos Rodrigues de Oliveira, Marcos Antonio Pessanha Barreto, Marcio Manhães Folly   +5 more
wiley   +1 more source

Allelic variations between vaccine strains and circulating strains in pxtP of Bordetella pertussis in Iran

Vaccine Research, 2015
Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the ...
F Sadeghpour Heravi, VS Nikbin, F Shahcheraghi   +2 more
doaj  

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, Volume 179, Issue 1, Page 54-71, September 2026.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Genomics of Bordetella pertussis toxins

International Journal of Medical Microbiology, 2000
Bordetella pertussis, the etiologic agent of whooping cough, produces numerous toxins including pertussis toxin (PTX), adenylate cyclase toxin (AC), dermonecrotic toxin (DNT) and tracheal cytotoxin (TCT). PTX is composed of five different subunits organised in a typical A-B type structure of which the A part possesses an enzymatic ADP ...
R, Antoine, D, Raze, C, Locht
openaire   +2 more sources

Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine. [PDF]

, 1994
The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129G, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole ...
RAPPUOLI R. AND THE ITALIAN MULTICENTER GROUP FOR THE STUDY OF RECOMBINANT ACELLULAR PERTUSSIS VACCINE, PEPPOLONI, Samuele, MAIDA A., FURLAN R., UXA F., CARAPELLA DE LUCA E., NENCIONI L., CONTU B., TITONE L., MOIRAGHI A., STRAMARE D., DI PISA F., PODDA A.   +12 more
core  

Effect of pertussis toxin on hormonal responsiveness of rat hepatocytes [PDF]

, 1983
The ureogenic action of epinephrine in hepatocytes from normal adult rats is mediated through activation of α1-adrenoceptors. β-Adrenoceptors in addition to α1-adrenoceptors, became involved in mediating this effect in cells from animals treated with ...
J. Adolfo García-Sáinz, Silvia Corvera, Corvera, Silvia, Pushpendran, Choliparambil K., Adolfo García-Sáinz, J., Choliparambil K. Pushpendran   +5 more
core   +1 more source

Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against Bordetella pertussis colonization

mSphere
The adenylate cyclase toxin (ACT, AC-Hly, or CyaA) plays a key role in airway infections by Bordetella pertussis and ablates the oxidative burst and opsonophagocytic capacity of sentinel phagocytes.
Carlos Espinosa-Vinals, Jana Holubova, Ondrej Stanek, Radim Osicka, Jiri Masin, Fresia Esther Arellano Herencia, Peter Sebo   +6 more
doaj   +1 more source

Protein–Protein Interactions Between Peptidoglycan, Lipopolysaccharide, and Phospholipid Biosynthesis Enzymes in Escherichia coli

ChemBioChem, Volume 27, Issue 16, 27 August 2026.
MurA, the first peptidoglycan biosynthesis enzyme, interacts with essential proteins involved in lipopolysaccharide and phospholipid biogenesis and is associated with the LapB interactome. Gram‐negative bacteria are protected by a three‐layered cell envelope and must tightly coordinate the biosynthesis of phospholipids (PL), peptidoglycan (PG) and ...
Lea‐Janina Tilg, Sophia Weber, Hannah Bille, Anna‐Maria Möller, Franz Narberhaus   +4 more
wiley   +1 more source