Results 91 to 100 of about 33,335 (199)

Purification design and practice for pertactin, the third component of acellular pertussis vaccine, from Bordetella pertussis [PDF]

, 2016
Development of acellular pertussis vaccine (aPV) requires purification of several components from Bordetella pertussis. While the components pertussis toxin (PT) and filamentous hemagglutinin (FHA) have been successfully purified, the third component ...
Li, Zenglan, Zhang, Songping, Li, Zhengjun, Zhang, Guifeng, Wang, Qi, Zhang, Yan, Ma, Guanghui, Su, Zhiguo, Liu, Yongdong, Luo, Jian   +9 more
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Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai, Mengchen Ma, Yuqin Zhu, Mengru Shi, Xiaoyan Dai, Yujie Wang, Mengru Li, Yanwen Yu, Yajiao Wang, Liang Xu   +9 more
wiley   +1 more source

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, Volume 115, Issue 8, Page 1646-1653, August 2026.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source

Parents as source of pertussis transmission in hospitalized young infants [PDF]

, 2017
Purpose This study was planned to collect evidences of familial pertussis transmission to infants younger than 6 months of age. Understanding the dynamics of transmission of pertussis in families is essential to plan effective prevention strategies ...
Stefanelli P., Palazzo R., Villani A., Rizzo C, Nicolai A., Agricola E., Carsetti R., Tozzi A.E., Midulla F., The Pertussis Study Group, Concato C., Fedele G., Buttinelli G., Frassanito A., Ausiello C.M., Leone P., Campagna I., Russo L., Schiavoni I., Di Mattia G., Nenna R., Ferretti B., Marcellini V., Pandolfi E., Gesualdo F., Gonfiantini M.V., Carollo M.   +26 more
core   +1 more source

β3‐AR/β‐arrestin2 Interaction Triggers Cardiac Fibrosis Through JNK/c‐Jun Pathway in Cardiac Fibroblasts

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Myocardial fibrosis (MF) is a critical pathological substrate of heart failure (HF), and β3‐adrenergic receptor (β3‐AR) has been implicated in cardiac remodelling with controversial roles. This study aimed to clarify the pro‐fibrotic mechanism of β3‐AR in cardiac fibroblasts and its association with β‐arrestin2‐mediated biased activation ...
Zhongcheng Xu, Min Zhu, Chun Zhou, Juncang Duan, Jian Ding, Jun Liu, Xuan Ying, Jie Wu, Yang Dong, Wenbiao Wang, Zhaohui Qiu   +10 more
wiley   +1 more source

Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats [PDF]

We used isolated islets of lean and obese Zucker rats to determine whether inhibitory pathways mediated by pertussis toxin-sensitive guanyl nucleotide-binding (Gi) proteins contribute to hyperinsulinemia in obese rats.

core   +1 more source

Entwicklung eines Tests zur Ablösung von Tierversuchen beim Nachweis von Pertussis-Toxin [PDF]

, 2010
Weltweit existiert keine zum Tierversuch alternative Methode, um adsorbierte Pertussis-Impfstoffe auf restliche Toxin-Aktivität hin zu untersuchen.
Bache, Christina Natalia Erika
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The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors

Toxins
The life-threatening disease pertussis, also known as whooping cough, is caused by a complex interplay of several virulence factors produced by the bacterium Bordetella (B.) pertussis.
Stefanie Lietz, Holger Barth
doaj   +1 more source

Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis : a role for toxin-filamentous haemagglutinin interaction [PDF]

, 2002
Summary Adenylate cyclase (AC) toxin from Bordetella pertussis is unusual in that, unlike most other members of the repeats-in-toxin family that are released into the extracellular milieu, it remains associated with the bacterial surface.
Mary C Gray, Franca R Zaretzky, Erik L Hewlett   +2 more
core  

PENGARUH pH ELUEN TERHADAP HASIL DESALTING CRUDE PERTUSSIS TOXIN (PT) DAN FILAMENTOUS HEMAGGLUTININ (FHA) DARI Bordetella pertussis [PDF]

, 2014
Optimizing desalting crude process of PT and FHA using sephadex G-25 as intermediate purification phase for PT and FHA as acellular pertussis vaccine components has been developed.
Neni Nurainy, Esti Hendradi, Faris Adrianto, Isnaeni   +3 more
core