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Experimental Biology and Medicine, 1933 Mishulow, Mowry and Scott1 demonstrated that exotoxic filtrates could be obtained from whooping cough cultures. They planted their organisms on chocolate agar over which they had poured a small amount of horse serum-beef heart broth. The small amount of diluent made the harvest of toxin necessarily small. On the other hand, Craster and Smith2 mentioned
J. A. Toomey, J. E. McClelland
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Past and Present Vaccinations in Sweden
Acta Paediatrica, Volume 115, Issue 11, Page 2505-2510, November 2026.
Sven Arne Silfverdal
wiley +1 more source
Entwicklung eines Tests zur Ablösung von Tierversuchen beim Nachweis von Pertussis-Toxin [PDF]
, 2010 Weltweit existiert keine zum Tierversuch alternative Methode, um adsorbierte Pertussis-Impfstoffe auf restliche Toxin-Aktivität hin zu untersuchen.
Bache, Christina Natalia Erika
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mBio, 2019 Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that binds myeloid ...
Jawid Nazir Ahmad +6 more
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Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine.
, 1994 The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129G, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole ...
RAPPUOLI R. AND THE ITALIAN MULTICENTER GROUP FOR THE STUDY OF RECOMBINANT ACELLULAR PERTUSSIS VACCINE +12 more
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PLoS ONE, 2011 Pertussis (whooping cough) is frequently complicated by concomitant infections with respiratory viruses. Here we report the effect of Bordetella pertussis infection on subsequent influenza virus (PR8) infection in mouse models and the role of pertussis ...
Victor I Ayala +4 more
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Two cysteine dioxygenase homologs contribute to the fitness and virulence of a human pathogen
Microbiology SpectrumBordetella pertussis is a strictly human, re-emerging respiratory pathogen and the causative agent of whooping cough. Through its adaptation to humans, B.
Argha Saha +6 more
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Effects of pertussis toxin treatment on metabolism in hamster brown adipocytes
, 1985 This communication reports the effects of the exotoxin of Bordetella pertussis (pertussis toxin) on hamster brown fat cells. Pertussis toxin significantly increased the lipolytic and respiratory responses to isoproterenol but did not increase the basal ...
R. J. Schimmel +2 more
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PENGARUH pH ELUEN TERHADAP HASIL DESALTING CRUDE PERTUSSIS TOXIN (PT) DAN FILAMENTOUS HEMAGGLUTININ (FHA) DARI Bordetella pertussis [PDF]
, 2014 Optimizing desalting crude process of PT and FHA using sephadex G-25 as intermediate purification phase for PT and FHA as acellular pertussis vaccine components has been developed.
Neni Nurainy +3 more
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Brain damage following whooping cough vaccination : is it time to lay the myth to rest? [PDF]
, 1998 Whooping cough causes significant morbidity and mortality, especially in early infancy. Although an effective vaccine exists, vaccine uptake in Malta was previously disappointing due to the general public’s and the medical community’s doubts regarding ...
Busuttil, Ray, Grech, Victor E.
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