Results 81 to 90 of about 32,826 (199)

High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji, Peipei Chen, Huaiping Tang, Chao Zhou, Zihao Li, Yunshu Wang, Xiang Cao, Liwen Zhu, Xinyu Bao, Zhuo Liu, Yan Chen, Yun Xu   +11 more
wiley   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, Volume 183, Issue 10, Page 2219-2235, May 2026.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, Volume 183, Issue 10, Page 2360-2375, May 2026.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Hepatitis B Virus, Pneumococcal, Diphtheria, and Tetanus Vaccination Responses in Compensated Cirrhosis

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Cirrhosis favours infections that can lead to liver decompensation and death. Some of these infections can be prevented by vaccination. This study aimed to evaluate the immune response after HBV, pneumococcal, diphtheria, and tetanus vaccination in cirrhotic patients.
Vincent Haghnejad, Mélissa Lucas, Lucie Chevrier, Hélène Jeulin, Isabela Quilici, Sébastien Daude, Mouni Bensenane‐Oussalah, Nicolas Jacquinot, Evelyne Schvoerer, Frederic Batteux, Jean Pierre Bronowicki   +10 more
wiley   +1 more source

Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018

, 2021
International audienceBackground: Bordetella pertussis is the main agent of whooping cough. Vaccination with acellular pertussis vaccines has been largely implemented in high-income countries. These vaccines contain 1 to 5 antigens: pertussis toxin (PT),
Bouchez, Valérie, Brisse, Sylvain, Microbiology Study Group, French Pertussis, Armatys, Nathalie, Toubiana, Julie, Landier, Annie, Matczak, Soraya, Guillot, Sophie   +7 more
core   +1 more source

Entwicklung eines Tests zur Ablösung von Tierversuchen beim Nachweis von Pertussis-Toxin [PDF]

, 2010
Weltweit existiert keine zum Tierversuch alternative Methode, um adsorbierte Pertussis-Impfstoffe auf restliche Toxin-Aktivität hin zu untersuchen.
Bache, Christina Natalia Erika
core   +1 more source

The Battle Against Pertussis: Discovery of Endogenous Human Proteins and Peptides as Toxin-Inhibitors

Toxins
The life-threatening disease pertussis, also known as whooping cough, is caused by a complex interplay of several virulence factors produced by the bacterium Bordetella (B.) pertussis.
Stefanie Lietz, Holger Barth
doaj   +1 more source

Effects of pertussis toxin treatment on metabolism in hamster brown adipocytes

, 1985
This communication reports the effects of the exotoxin of Bordetella pertussis (pertussis toxin) on hamster brown fat cells. Pertussis toxin significantly increased the lipolytic and respiratory responses to isoproterenol but did not increase the basal ...
R. J. Schimmel, L. McCarthy, D. Dzierzanowski   +2 more
core   +1 more source

Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis : a role for toxin-filamentous haemagglutinin interaction [PDF]

, 2002
Summary Adenylate cyclase (AC) toxin from Bordetella pertussis is unusual in that, unlike most other members of the repeats-in-toxin family that are released into the extracellular milieu, it remains associated with the bacterial surface.
Mary C Gray, Franca R Zaretzky, Erik L Hewlett   +2 more
core  

Anti-pertussis toxin IgG level in the Thai population.

, 2016
Anti-pertussis toxin IgG level in the Thai population.
Thanunrat Thongmee (732724), Nasamon Wanlapakorn (2142889), Sompong Vongpunsawad (684928), Yong Poovorawan (39511), Varisara Ngaovithunvong (2142892), Preeyaporn Vichaiwattana (732720)   +5 more
core   +1 more source