Results 61 to 70 of about 32,826 (199)

Adaptation of Bordetella pertussis to Vaccination: A Cause for Its Reemergence?

Emerging Infectious Diseases, 2001
In The Netherlands, as in many other western countries, pertussis vaccines have been used extensively for more than 40 years. Therefore, it is conceivable that vaccine-induced immunity has affected the evolution of B. pertussis.
Frits R. Mooi, Inge H. M. van Loo, Audrey King   +2 more
doaj   +1 more source

Genomics of Bordetella pertussis toxins

International Journal of Medical Microbiology, 2000
Bordetella pertussis, the etiologic agent of whooping cough, produces numerous toxins including pertussis toxin (PTX), adenylate cyclase toxin (AC), dermonecrotic toxin (DNT) and tracheal cytotoxin (TCT). PTX is composed of five different subunits organised in a typical A-B type structure of which the A part possesses an enzymatic ADP ...
R, Antoine, D, Raze, C, Locht
openaire   +2 more sources

Evidence for a Two‐Step Model for Activation of GPR25 by the Chemoattractant CXCL17

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT CXCL17 was recently reported to activate GPR25, a receptor expressed by T‐regulatory cells. Although classified as a chemokine, the activity of CXCL17 is ablated by minor C‐terminal truncation, suggesting a novel mode of receptor activation. We set out to test this hypothesis by mutagenesis. GPR25 was expressed in the murine pre‐B cell line L1.
Wuqing Yang, Sean P. Giblin, James E. Pease   +2 more
wiley   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, Volume 183, Issue 14, Page 4058-4071, July 2026.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. bronchiseptica.

PLoS Pathogens, 2005
Bordetella pertussis, B. bronchiseptica, B. parapertussis(hu), and B. parapertussis(ov) are closely related respiratory pathogens that infect mammalian species. B. pertussis and B.
Dimitri A Diavatopoulos, Craig A Cummings, Leo M Schouls, Mary M Brinig, David A Relman, Frits R Mooi   +5 more
doaj   +2 more sources

Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection

mSphere
Pertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP).
Karolína Škopová, Jana Holubová, Barbora Bočková, Eva Slivenecká, João Melo Santos de Barros, Ondřej Staněk, Peter Šebo   +6 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Efficacy and Safety of Lianhua Qingke Tablets in Children With Mycoplasma pneumoniae Pneumonia: A Randomized, Double‐Blind, Multicenter, Placebo‐Controlled Clinical Trial

The Clinical Respiratory Journal, Volume 20, Issue 7, July 2026.
In this randomized, double‐blind, placebo‐controlled trial involving 160 children with mild Mycoplasma pneumoniae pneumonia, adding Lianhua Qingke tablets to conventional therapy significantly improved symptom resolution by Day 7 (85.9% vs. 65.6%) and shortened median recovery time (4.5 vs.
He Wang, Haiwei Dou, Guangying Chen, Yanmin Wei, Hua Li, Shuqiong Xu, Rongzhen Kang, Shanhong Liu, Long Zhang, Nan Li, Hongli Sun, Chi Wang, Jie Zhao, Jirong Yi, Wentao Song, Hongrong Li, Rong Ma, Kunling Shen, Deli Xin, Wenjie Qi   +19 more
wiley   +1 more source

Allelic variations between vaccine strains and circulating strains in pxtP of Bordetella pertussis in Iran

Vaccine Research, 2015
Introduction: Despite high level of vaccination against pertussis‚ whooping cough has re-emerged as a health threat, especially in infants. This could be related to expansion of Bordetella pertussis with novel alleles for virulence factors including the ...
F Sadeghpour Heravi, VS Nikbin, F Shahcheraghi   +2 more
doaj  

Pertussis toxin is required for pertussis vaccine encephalopathy. [PDF]

Proceedings of the National Academy of Sciences, 1985
A mouse model for encephalopathy induced by pertussis immunization has been described; it has features that closely resemble some of the severe reactions, including seizures and a shock-like state leading to death, occasionally seen after administration of Bordetella pertussis (whooping cough) vaccine.
L, Steinman, A, Weiss, N, Adelman, M, Lim, R, Zuniga, J, Oehlert, E, Hewlett, S, Falkow   +7 more
openaire   +2 more sources