Results 21 to 30 of about 32,826 (199)

Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Bordetella pertussis Vaccines

Toxins, 2021
The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz, Jeffery Gerard, Benjamin Messham, Wai Wan Vivian Tam, D. Andrew James   +4 more
doaj   +1 more source

Evaluation of Pertussis Toxin Expression in B2 and THIJS Media [PDF]

Archives of Razi Institute, 2019
Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi
H. Moradtalab, M. Noofeli, H. Zeighami, F. Haghi   +3 more
doaj   +1 more source

PECULIARITIES OF THE COURSE OF COVID-19 IN SCHOOL-AGE CHILDREN AS A FUNCTION OF HUMORAL IMMUNITY AGAINST PERTUSSIS

Неонатологія, хірургія та перинатальна медицина, 2023
Coronavirus disease remains one of the most serious diseases in the world. The percentage of severe and fatal cases in children is lower than in adults. The search for biomarkers of disease severity continues.
Г. Павлишин, О. Панченко, К. Козак   +2 more
doaj   +1 more source

Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]

, 2006
Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R., Scrivens, JH, Williams, Jonathan P., Scrivens, James H., Williams, JP, Roberts, LM, Marsden, Brian D., Smith, Daniel C., Marsden, BD, Smith, DC, Roberts, Lynne M., Scrivens, James, Green, BN, Green, Brian N., Roberts, L. M. (Lynne M.), Jennings, KR   +15 more
core   +1 more source

The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.

PLoS Pathogens, 2022
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms.
Jana Holubova, Ondrej Stanek, Attila Juhasz, Illiassou Hamidou Soumana, Peter Makovicky, Peter Sebo   +5 more
doaj   +1 more source

A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants

BMC Medicine, 2021
Background Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants’ antigen-specific immunoglobulin G (IgG) concentrations.
Christine Elizabeth Jones, Anna Calvert, Jo Southern, Mary Matheson, Nick Andrews, Asma Khalil, Hannah Cuthbertson, Bassam Hallis, Anna England, Paul T. Heath, Elizabeth Miller   +10 more
doaj   +1 more source

PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice

Toxins, 2021
Whooping cough is a severe, highly contagious disease of the human respiratory tract, caused by Bordetellapertussis. The pathogenicity requires several virulence factors, including pertussis toxin (PTX), a key component of current available vaccines ...
Julie Tomas, Yoon Koo, Dimitri Popoff, Vilma Arce-Gorvel, Sean Hanniffy, Jean-Pierre Gorvel, Cyrille Mionnet   +6 more
doaj   +1 more source

Protective Activity and Safety of Acellular Pertussis Vaccine from Vaccine and Freshly Isolated Strain Bordetella pertussis

Эпидемиология и вакцинопрофилактика, 2017
Goal. Study of the protective activity and safety of acellular pertussis vaccine (APV) using freshly isolated strain of B. pertussis. Materials and methods. Mice-hybrids F1 (CBAxC57Bl6). The B. pertussis strains: vaccine strains No. 305, No. 203, freshly
E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina   +2 more
doaj   +1 more source

Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally. [PDF]

PLoS ONE, 2014
Pertussis is a highly contagious, acute respiratory disease in humans caused by the Gram-negative pathogen Bordetella pertussis. Pertussis has resurged in the face of intensive vaccination and this has coincided with the emergence of strains carrying a ...
Daan de Gouw, Peter W M Hermans, Hester J Bootsma, Aldert Zomer, Kees Heuvelman, Dimitri A Diavatopoulos, Frits R Mooi   +6 more
doaj   +1 more source

G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies. [PDF]

PLoS ONE, 2009
BACKGROUND:Reprogramming adult human somatic cells to create human induced pluripotent stem (hiPS) cell colonies involves a dramatic morphological and organizational transition.
Kenta Nakamura, Nathan Salomonis, Kiichiro Tomoda, Shinya Yamanaka, Bruce R Conklin   +4 more
doaj   +1 more source