Results 21 to 30 of about 51,446 (212)

The Fim and FhaB adhesins play a crucial role in nasal cavity infection and Bordetella pertussis transmission in a novel mouse catarrhal infection model.

PLoS Pathogens, 2022
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms.
Jana Holubova, Ondrej Stanek, Attila Juhasz, Illiassou Hamidou Soumana, Peter Makovicky, Peter Sebo   +5 more
doaj   +1 more source

Ca2+-Stimulated Catecholamine Release from alpha-Toxin Permeabilized PC12 Cells [PDF]

, 1987
Two possible cellular pathways of catecholamines from the chromaffin vesicles of PC 12 cells to the surrounding medium are explored in this study. The direct one circumventing the cytoplasm can be activated in a-toxin-permeabilized cells with micromolar ...
Ahnert-Hilger, G., Bräutigam, M., Gratzl, Manfred   +2 more
core   +1 more source

Genetically detoxified pertussis toxin induces superior antigen specific CD4 T cell responses compared to chemically detoxified pertussis toxin

Human Vaccines & Immunotherapeutics, 2019
Pertussis is resurgent worldwide. Currently available acellular pertussis vaccines contain chemically detoxified pertussis toxin (PTc); a highly immunogenic genetically detoxified pertussis toxin (PTg) vaccine has been off the market for over a decade ...
Naveen Surendran, Michael Pichichero
doaj   +1 more source

A phase IV, multi-centre, randomized clinical trial comparing two pertussis-containing vaccines in pregnant women in England and vaccine responses in their infants

BMC Medicine, 2021
Background Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants’ antigen-specific immunoglobulin G (IgG) concentrations.
Christine Elizabeth Jones, Anna Calvert, Jo Southern, Mary Matheson, Nick Andrews, Asma Khalil, Hannah Cuthbertson, Bassam Hallis, Anna England, Paul T. Heath, Elizabeth Miller   +10 more
doaj   +1 more source

PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice

Toxins, 2021
Whooping cough is a severe, highly contagious disease of the human respiratory tract, caused by Bordetellapertussis. The pathogenicity requires several virulence factors, including pertussis toxin (PTX), a key component of current available vaccines ...
Julie Tomas, Yoon Koo, Dimitri Popoff, Vilma Arce-Gorvel, Sean Hanniffy, Jean-Pierre Gorvel, Cyrille Mionnet   +6 more
doaj   +1 more source

Increase in pertussis cases along with high prevalence of two emerging genotypes of Bordetella pertussis in Perú, 2012 [PDF]

, 2016
As has occurred in many regions worldwide, in 2012 the incidence of pertussis increased in Perú. This epidemiologic situation has been associated with a waning vaccine-induced immunity and the adaptation of Bordetella pertussis to vaccine-induced ...
Bailon, H, Hozbor, Daniela Flavia, León-Janampa, N, Padilla, C.   +3 more
core   +3 more sources

Protection against pertussis in humans correlates to elevated serum antibodies and memory B cells [PDF]

, 2017
Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Carsetti, Rita, Di Mattia, G., Fedele, Giorgio, Frassanito, A., Gesualdo, Francesco, Leone, Pasqualina, Marcellini, Valentina, Midulla, Fabio, Mortari, Eva Piano, Nenna, R., Pandolfi, Elisabetta, Stefanelli, Paola, The Pertussis Study, Gropu, Tozzi, Alberto Eugenio   +13 more
core   +1 more source

Protective Activity and Safety of Acellular Pertussis Vaccine from Vaccine and Freshly Isolated Strain Bordetella pertussis

Эпидемиология и вакцинопрофилактика, 2017
Goal. Study of the protective activity and safety of acellular pertussis vaccine (APV) using freshly isolated strain of B. pertussis. Materials and methods. Mice-hybrids F1 (CBAxC57Bl6). The B. pertussis strains: vaccine strains No. 305, No. 203, freshly
E. M. Zaitsev, I. G. Bazhanova, M. V. Britsina   +2 more
doaj   +1 more source

Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally. [PDF]

PLoS ONE, 2014
Pertussis is a highly contagious, acute respiratory disease in humans caused by the Gram-negative pathogen Bordetella pertussis. Pertussis has resurged in the face of intensive vaccination and this has coincided with the emergence of strains carrying a ...
Daan de Gouw, Peter W M Hermans, Hester J Bootsma, Aldert Zomer, Kees Heuvelman, Dimitri A Diavatopoulos, Frits R Mooi   +6 more
doaj   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources