Results 21 to 30 of about 33,335 (199)
Toxins, 2021 The antigens for acellular pertussis vaccines are made up of protein components that are purified directly from Bordetella pertussis (B. pertussis) bacterial fermentation. As such, there are additional B.
Lisa Szymkowicz +4 more
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Evaluation of Pertussis Toxin Expression in B2 and THIJS Media [PDF]
Archives of Razi Institute, 2019 Whole-cell pertussis vaccine (wP) has been imperative and highly effective in preventing childhood deaths due to pertussis. Pertussis toxin is one of the virulence factors of Bordetella pertussis in all available pertussis vaccines. wP production in Razi
H. Moradtalab +3 more
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Неонатологія, хірургія та перинатальна медицина, 2023 Coronavirus disease remains one of the most serious diseases in the world. The percentage of severe and fatal cases in children is lower than in adults. The search for biomarkers of disease severity continues.
Г. Павлишин +2 more
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The actions of Pasteurella multocida toxin on neuronal cells [PDF]
, 2014 Pasteurella multocida toxin (PMT) activates the G-proteins Gα, Gα, Gα Gα and Gα by deamidation of specific glutamine residues. A number of these alpha subunits have signalling roles in neurones.
Lax, Alistair; id_orcid +13 more
core +1 more source
Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]
, 2006 Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R. +15 more
core +1 more source
Parenteral immunization of mice with a genetically inactivated pertussis toxin DNA vaccine induces cell-mediated immunity and protection [PDF]
, 2008 The immunogenicity and protective efficacy of a DNA vaccine encoding a genetically inactivated S1 domain of pertussis toxin was evaluated using a murine respiratory challenge model of Bordetella pertussis infection.
Trilochan K. S. Mukkur +7 more
core +1 more source
PLoS Pathogens, 2022 Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms.
Jana Holubova +5 more
doaj +1 more source
Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins [PDF]
, 2009 The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
core +1 more source
BMC Medicine, 2021 Background Pertussis vaccines containing three or five pertussis antigens are recommended in pregnancy in many countries, but no studies have compared the effect on infants’ antigen-specific immunoglobulin G (IgG) concentrations.
Christine Elizabeth Jones +10 more
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PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected Mice
Toxins, 2021 Whooping cough is a severe, highly contagious disease of the human respiratory tract, caused by Bordetellapertussis. The pathogenicity requires several virulence factors, including pertussis toxin (PTX), a key component of current available vaccines ...
Julie Tomas +6 more
doaj +1 more source