Results 31 to 40 of about 232 (115)
Medical Countermeasures against Ricin Intoxication
Toxins, 2023 Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil +1 more
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Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being
Toxins, 2014 Some pathogenic spore-forming bacilli employ a binary protein mechanism for intoxicating the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their toxins include Clostridium botulinum (C2 toxin), Clostridium difficile (
Bradley G. Stiles +5 more
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AB 5 Preassembly Is Not Required for Shiga Toxin Activity [PDF]
Journal of Bacteriology, 2016 ABSTRACT Shiga toxin (Stx)-producing Escherichia coli (STEC) is a major cause of foodborne illness, including the life-threatening complication hemolytic-uremic syndrome. The German outbreak in 2011 resulted in nearly 4,000 cases of infection, with 54 deaths.
Christine A, Pellino +3 more
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Role of Homologous Fc Fragment in the Potency and Efficacy of Anti‐Botulinum Antibody Preparations
Toxins, 2017 The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incidence of
Amram Torgeman +9 more
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Human Peptides α-Defensin-1 and -5 Inhibit Pertussis Toxin
Toxins, 2021 Bordetella pertussis causes the severe childhood disease whooping cough, by releasing several toxins, including pertussis toxin (PT) as a major virulence factor.
Carolin Kling +3 more
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Purification and some properties of Clostridium botulinum type AB toxin [PDF]
FEMS Microbiology Letters, 1986 Abstract The progenitor toxin of Clostridium botulinum type AB was purified; both large-sized (L) and medium-sized (M) toxins were found. The toxicity of M toxin increased by about 10-fold upon trypsinization; the increase was due mostly to type B toxin and a little to type A toxin.
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Toxins, 2017 Ricin is a type II ribosome-inactivating toxin that catalytically inactivates ribosomes ultimately leading to cell death. The toxicity of ricin along with the prevalence of castor beans (its natural source) has led to its increased notoriety and ...
Sarah J. C. Whitfield +8 more
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Microbiology SpectrumNEDD8 is a ubiquitin-like molecule that is conjugated to lysine residues of protein substrates in a process known as neddylation, which affects their stability, degradation, and interactions.
Irina König +4 more
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Uptake and Processing of the Cytolethal Distending Toxin by Mammalian Cells
Toxins, 2014 The cytolethal distending toxin (Cdt) is a heterotrimeric holotoxin produced by a diverse group of Gram-negative pathogenic bacteria. The Cdts expressed by the members of this group comprise a subclass of the AB toxin superfamily.
Joseph M. DiRienzo
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A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. [PDF]
PLoS Pathogens, 2007 The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B.
Darly J Manayani +12 more
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