Dynamic Duo—The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin [PDF]
Toxins, 2016 The cytolethal distending toxin (CDT) is a well characterized bacterial genotoxin encoded by several Gram-negative bacteria, including Salmonella enterica (S. enterica).
Rachel Miller +2 more
exaly +8 more sources
Cytolethal Distending Toxin Subunit B: A Review of Structure–Function Relationship [PDF]
Toxins, 2019 The Cytolethal Distending Toxin (CDT) is a bacterial virulence factor produced by several Gram-negative pathogenic bacteria. These bacteria, found in distinct niches, cause diverse infectious diseases and produce CDTs differing in sequence and structure.
Benoit J Pons +2 more
exaly +10 more sources
Revisiting bacterial cytolethal distending toxin structure and function [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Cytolethal distending toxins (CDTs) are intracellular-acting bacterial genotoxins generated by a diverse group of mucocutaneous human pathogens. CDTs must successfully bind to the plasma membrane of host cells in order to exert their modulatory effects ...
Henry Chen +6 more
doaj +4 more sources
From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin [PDF]
Frontiers in Immunology, 2021 Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis.
Jason Ma +2 more
exaly +4 more sources
Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B [PDF]
Toxins, 2020 The Cytolethal Distending Toxin (CDT) is produced by many Gram-negative pathogenic bacteria responsible for major foodborne diseases worldwide. CDT induces DNA damage and cell cycle arrest in host-cells, eventually leading to senescence or apoptosis ...
Benoît J. Pons +5 more
doaj +3 more sources
Rab4b Promotes Cytolethal Distending Toxin from Glaesserella parasuis-Induced Cytotoxicity in PK-15 Cells [PDF]
ToxinsGlaesserella parasuis cytolethal distending toxin (GpCDT) can induce cell cycle arrest and apoptosis. Our laboratory’s previous work demonstrated that GTPase 4b (Rab4b) is a key host protein implicated in GpCDT-induced cytotoxicity.
Yiwen Zhang +14 more
doaj +3 more sources
Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Cytolethal distending toxins (Cdt) are a family of toxins produced by several human pathogens which infect mucocutaneous tissue and induce inflammatory disease.
Taewan J. Kim +6 more
doaj +2 more sources
Campylobacter jejuni Cytolethal Distending Toxin Induces GSDME-Dependent Pyroptosis in Colonic Epithelial Cells [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundCytolethal distending toxin (CDT) is a critical virulence factor of Campylobacter jejuni, and it induces cell death and regulates inflammation response in human epithelial cells. Pyroptosis is an inflammatory form of programmed cell death (PCD),
Jiayun Gu +15 more
doaj +2 more sources
Helicobacter hepaticus Induce Colitis in Male IL-10−/− Mice Dependent by Cytolethal Distending Toxin B and via the Activation of Jak/Stat Signaling Pathway [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 It has been well documented that cytolethal distending toxin (CDT) from Helicobacter hepaticus (H. hepaticus), Campylobacter jejuni (C. jejuni) and other Gram-negative intestinal pathogens is linked to the inflammatory bowel disease (IBD).
Liqi Zhu +8 more
doaj +2 more sources
Engineering of Cytolethal Distending Toxin B by Its Reducing Immunogenicity and Maintaining Stability as a New Drug Candidate for Tumor Therapy; an In Silico Study [PDF]
Toxins, 2021 The cytolethal distending toxin (CDT), Haemophilus ducreyi, is one of the bacterial toxins that have recently been considered for targeted therapies, especially in cancer therapies. CDT is an A-B2 exotoxin.
Maryam Keshtvarz +8 more
doaj +2 more sources