Results 11 to 20 of about 2,764 (156)

Uptake and Processing of the Cytolethal Distending Toxin by Mammalian Cells [PDF]

Toxins, 2014
The cytolethal distending toxin (Cdt) is a heterotrimeric holotoxin produced by a diverse group of Gram-negative pathogenic bacteria. The Cdts expressed by the members of this group comprise a subclass of the AB toxin superfamily.
Joseph M Dirienzo
exaly   +5 more sources

The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective [PDF]

Cells, 2014
The cytolethal distending toxin (CDT) is produced by many pathogenic Gram-negative bacteria and is considered as a virulence factor. In human cells, CDT exposure leads to a unique cytotoxicity associated with a characteristic cell distension and induces
Julien Vignard, Gladys Mirey, Mirey Gladys   +2 more
exaly   +8 more sources

TM9SF4 acts as a receptor mediating Glaesserella parasuis cytolethal distending toxin–induced cytotoxicity in PK15 cells [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundCytolethal Distending Toxin (CDT) is the only exotoxin that Glaesserella parasuis (G. parasuis) can secrete. G. parasuis CDT (GpCDT) triggers DNA damage responses, leading to irreversible cell cycle arrest and apoptosis, playing an important ...
Li Lei, Shiyu Xu, Zhen Yang, Xingyu Pan, Jiali Xu, Senyan Du, Qin Zhao, Xiaobo Huang, Sanjie Cao, Rui Wu, Yiping Wang, Qigui Yan, Yiping Wen   +12 more
doaj   +2 more sources

Corrigendum: Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
Taewan J. Kim, Taewan J. Kim, Bruce J. Shenker, Andrew S. MacElroy, Samuel Spradlin, Lisa P. Walker, Kathleen Boesze-Battaglia   +6 more
doaj   +2 more sources

Rab4b Promotes Cytolethal Distending Toxin from Glaesserella parasuis-Induced Cytotoxicity in PK-15 Cells [PDF]

Toxins
Glaesserella parasuis cytolethal distending toxin (GpCDT) can induce cell cycle arrest and apoptosis. Our laboratory’s previous work demonstrated that GTPase 4b (Rab4b) is a key host protein implicated in GpCDT-induced cytotoxicity.
Yiwen Zhang, Zhen Yang, Ke Dai, Bangdi Hu, Shiyu Xu, Yu Wang, Li Lei, Senyan Du, Qin Zhao, Xiaobo Huang, Rui Wu, Qigui Yan, Yiping Wang, Sanjie Cao, Yiping Wen   +14 more
doaj   +2 more sources

The Cell-Cycle Regulatory Protein p21^CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis [PDF]

Pathogens, 2020
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Bruce J. Shenker, Lisa M. Walker, Ali Zekavat, Robert H. Weiss, Kathleen Boesze-Battaglia   +4 more
doaj   +2 more sources

Molecular Mechanisms and Potential Clinical Applications of Campylobacter jejuni Cytolethal Distending Toxin

Frontiers in Cellular and Infection Microbiology, 2016
Cytolethal distending toxin (CDT), a genotoxin produced by Campylobacter jejuni, is composed of three subunits: CdtA, CdtB, and CdtC. CdtB is a DNase that causes DNA double-strand breaks (DSB) in the nucleus resulting in cell cycle arrest at the G2/M ...
Chih-Jung Chen, Chih-Ho Lai, Ho Lin
exaly   +3 more sources

Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation [PDF]

Frontiers in Immunology, 2019
The receptor for advanced glycation end products (RAGE) interacts with various molecules in the cell membrane to induce an inflammatory response. The cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB ...
Hwai-Jeng Lin, Hwai-Jeng Lin, Zhi-Pei Jiang, Zhi-Pei Jiang, Horng-Ren Lo, Chun-Lung Feng, Chun-Lung Feng, Chih-Jung Chen, Chia-Yu Yang, Chia-Yu Yang, Mei-Zi Huang, Hui-Yu Wu, Yu-An Chen, Yu Chen, Cheng-Hsun Chiu, Cheng-Hsun Chiu, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai   +19 more
doaj   +2 more sources

Corrigendum: Revisiting bacterial cytolethal distending toxin structure and function [PDF]

Frontiers in Cellular and Infection Microbiology
Henry Chen, Claire J. Ang, Molly K. Crowder, William M. Brieher, Steven R. Blanke, Steven R. Blanke, Steven R. Blanke   +6 more
doaj   +2 more sources

The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin

Frontiers in Cellular and Infection Microbiology, 2016
This review summarizes the current status and recent advances in our understanding of the role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease by toxin-producing pathogens.
Kathleen Boesze-Battaglia, Bruce Shenker, Mensur Dlakic   +2 more
exaly   +3 more sources