Toxins, 2016 The cytolethal distending toxin (CDT) is a well characterized bacterial genotoxin encoded by several Gram-negative bacteria, including Salmonella enterica (S. enterica).
Rachel Miller, Martin Wiedmann
exaly +4 more sources
Corrigendum: Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Taewan J. Kim +6 more
doaj +2 more sources
TM9SF4 acts as a receptor mediating Glaesserella parasuis cytolethal distending toxin–induced cytotoxicity in PK15 cells [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundCytolethal Distending Toxin (CDT) is the only exotoxin that Glaesserella parasuis (G. parasuis) can secrete. G. parasuis CDT (GpCDT) triggers DNA damage responses, leading to irreversible cell cycle arrest and apoptosis, playing an important ...
Li Lei +12 more
doaj +2 more sources
Memorias do Instituto Oswaldo Cruz, 2001 Genetic and phenotypic virulence markers of different categories of diarrhoeagenic Escherichia coli were investigated in 106 strains of enteropathogenic E. coli (EPEC) serogroup O86. The most frequent serotype found was O86:H34 (86%).
Ângela Cristina Rodrigues Ghilardi +2 more
doaj +4 more sources
Rab4b Promotes Cytolethal Distending Toxin from Glaesserella parasuis-Induced Cytotoxicity in PK-15 Cells [PDF]
ToxinsGlaesserella parasuis cytolethal distending toxin (GpCDT) can induce cell cycle arrest and apoptosis. Our laboratory’s previous work demonstrated that GTPase 4b (Rab4b) is a key host protein implicated in GpCDT-induced cytotoxicity.
Yiwen Zhang +14 more
doaj +2 more sources
The Cell-Cycle Regulatory Protein p21CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis [PDF]
Pathogens, 2020 The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Bruce J. Shenker +4 more
doaj +2 more sources
Uptake and Processing of the Cytolethal Distending Toxin by Mammalian Cells
Toxins, 2014 The cytolethal distending toxin (Cdt) is a heterotrimeric holotoxin produced by a diverse group of Gram-negative pathogenic bacteria. The Cdts expressed by the members of this group comprise a subclass of the AB toxin superfamily.
Joseph M Dirienzo
exaly +3 more sources
Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation [PDF]
Frontiers in Immunology, 2019 The receptor for advanced glycation end products (RAGE) interacts with various molecules in the cell membrane to induce an inflammatory response. The cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB ...
Hwai-Jeng Lin +19 more
doaj +2 more sources
Corrigendum: Revisiting bacterial cytolethal distending toxin structure and function [PDF]
Frontiers in Cellular and Infection MicrobiologyHenry Chen +6 more
doaj +2 more sources
BMC Microbiology, 2009 Background Background: Cytolethal distending toxin (CDT) is one of the well-characterized virulence factors of Campylobacter jejuni, but it is unknown how CDT becomes surface-exposed or is released from the bacterium to the surrounding environment ...
Uhlin Bernt +7 more
doaj +2 more sources