Signature Prediction Modeling in Cytolethal Distending Toxin-Producing Strains [PDF]
Genomics & Informatics, 2017 In this study, cytolethal distending toxin (CDT) producer isolates genome were compared with genome of pathogenic and commensal Escherichia coli strains. Conserved genomic signatures among different types of CDT producer E. coli strains were assessed. It
Maryam Javadi +2 more
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LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells [PDF]
Virulence, 2023 Glaesserella parasuis is an early colonizer of the swine upper respiratory tract and can break through the respiratory barrier for further invasion. However, the mechanisms underlying G.
Weiting Mao +10 more
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The Nuclear Remodeling Induced by Helicobacter Cytolethal Distending Toxin Involves MAFB Oncoprotein [PDF]
Toxins, 2020 Enterohepatic Helicobacters, such as Helicobacter hepaticus and Helicobacter pullorum, are associated with several intestinal and hepatic diseases. Their main virulence factor is the cytolethal distending toxin (CDT).
Christelle Péré-Védrenne +9 more
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TM9SF4 acts as a receptor mediating Glaesserella parasuis cytolethal distending toxin–induced cytotoxicity in PK15 cells [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundCytolethal Distending Toxin (CDT) is the only exotoxin that Glaesserella parasuis (G. parasuis) can secrete. G. parasuis CDT (GpCDT) triggers DNA damage responses, leading to irreversible cell cycle arrest and apoptosis, playing an important ...
Li Lei +12 more
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Uptake and Processing of the Cytolethal Distending Toxin by Mammalian Cells [PDF]
Toxins, 2014 The cytolethal distending toxin (Cdt) is a heterotrimeric holotoxin produced by a diverse group of Gram-negative pathogenic bacteria. The Cdts expressed by the members of this group comprise a subclass of the AB toxin superfamily.
Joseph M. DiRienzo
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Memorias do Instituto Oswaldo Cruz, 2001 Genetic and phenotypic virulence markers of different categories of diarrhoeagenic Escherichia coli were investigated in 106 strains of enteropathogenic E. coli (EPEC) serogroup O86. The most frequent serotype found was O86:H34 (86%).
Ângela Cristina Rodrigues Ghilardi +2 more
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Corrigendum: Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Taewan J. Kim +6 more
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The Cell-Cycle Regulatory Protein p21CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis [PDF]
Pathogens, 2020 The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Bruce J. Shenker +4 more
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BMC Microbiology, 2009 Background Background: Cytolethal distending toxin (CDT) is one of the well-characterized virulence factors of Campylobacter jejuni, but it is unknown how CDT becomes surface-exposed or is released from the bacterium to the surrounding environment ...
Uhlin Bernt +7 more
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The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective [PDF]
Cells, 2014 The cytolethal distending toxin (CDT) is produced by many pathogenic Gram-negative bacteria and is considered as a virulence factor. In human cells, CDT exposure leads to a unique cytotoxicity associated with a characteristic cell distension and induces
Elisabeth Bezine +2 more
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