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Frontiers in Cellular and Infection Microbiology, 2012 The cytolethal distending toxins (CDTs) comprise a family of intracellular-acting bacterial protein toxins whose actions upon eukaryotic cells result in several consequences, the most characteristic of which is the induction of G2/M cell cycle arrest ...
Blanke Steven R
exaly +3 more sources
The Biology of the Cytolethal Distending Toxins [PDF]
Toxins, 2011 The cytolethal distending toxins (CDTs), produced by a variety of Gram-negative pathogenic bacteria, are the first bacterial genotoxins described, since they cause DNA damage in the target cells. CDT is an A-B2 toxin, where the CdtA and CdtC subunits are required to mediate the binding on the surface of the target cells, allowing internalization of the
Guerra, Lina +3 more
openaire +3 more sources
Periodontology 2000, EarlyView., 2023 Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis +5 more
wiley +1 more source
Signature Prediction Modeling in Cytolethal Distending Toxin-Producing Strains [PDF]
Genomics & Informatics, 2017 In this study, cytolethal distending toxin (CDT) producer isolates genome were compared with genome of pathogenic and commensal Escherichia coli strains. Conserved genomic signatures among different types of CDT producer E. coli strains were assessed. It
Maryam Javadi +2 more
doaj +1 more source
Delivery, structure, and function of bacterial genotoxins
Virulence, 2022 Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells.
Liaoqi Du, Jeongmin Song
doaj +1 more source
Inflammatory and Bone Remodeling Responses to the Cytolethal Distending Toxins [PDF]
Cells, 2014 The cytolethal distending toxins (CDTs) are a family of exotoxins produced by a wide range of Gram-negative bacteria. They are known for causing genotoxic stress to the cell, resulting in growth arrest and eventually apoptotic cell death. Nevertheless, there is evidence that CDTs can also perturb the innate immune responses, by regulating ...
Belibasakis, Georgios N +1 more
openaire +4 more sources
Molecular Docking Study for Inhibitors of Aggregatibacter actinomycetamcomitans Toxins in Treatment of Aggressive Perioodontitis [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: Periodontitis is a chronic inflammatory disease of the periodontal tissues causing periodontal attachment loss and destruction of the alveolar bone which leads to mobility and loss of teeth.
Makesh Raj.L.S. +4 more
doaj +1 more source
A Journey of Cytolethal Distending Toxins through Cell Membranes [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 The multifunctional role of lipids as structural components of membranes, signaling molecules, and metabolic substrates makes them an ideal partner for pathogens to hijack host cell processes for their own survival. The properties and composition of unique membrane micro-domains such as membrane rafts make these regions a natural target for pathogens ...
Boesze-Battaglia, Kathleen +3 more
openaire +5 more sources
Prevalence of Cytolethal Distending Toxin Production in Periodontopathogenic Bacteria [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACTCytolethal distending toxin (CDT) is a newly identified virulence factor produced by several pathogenic bacteria implicated in chronic infection. Seventy three strains of periodontopathogenic bacteria were examined for the production of CDT by a HeLa cell bioassay and for the presence of thecdtgene by PCR with degenerative oligonucleotide ...
Yamano, R +12 more
openaire +3 more sources
Impact of CDT Toxin on Human Diseases
Toxins, 2016 Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the ...
Tiphanie Faïs +4 more
doaj +1 more source