<i>Campylobacter jejuni</i> extracellular vesicles harboring cytolethal distending toxin bind host cell glycans and induce cell cycle arrest in host cells. [PDF]
Microbiol SpectrCytolethal distending toxins (CDTs) are released by Gram-negative pathogens into the extracellular medium as free toxin or associated with extracellular vesicles (EVs), commonly known as outer membrane vesicles (OMVs).
Le LHM +7 more
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Signature Prediction Modeling in Cytolethal Distending Toxin-Producing Strains [PDF]
Genomics & Informatics, 2017 In this study, cytolethal distending toxin (CDT) producer isolates genome were compared with genome of pathogenic and commensal Escherichia coli strains. Conserved genomic signatures among different types of CDT producer E. coli strains were assessed. It
Maryam Javadi +2 more
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Delivery, structure, and function of bacterial genotoxins
Virulence, 2022 Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells.
Liaoqi Du, Jeongmin Song
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Molecular Docking Study for Inhibitors of Aggregatibacter actinomycetamcomitans Toxins in Treatment of Aggressive Perioodontitis [PDF]
Journal of Clinical and Diagnostic Research, 2014 Introduction: Periodontitis is a chronic inflammatory disease of the periodontal tissues causing periodontal attachment loss and destruction of the alveolar bone which leads to mobility and loss of teeth.
Makesh Raj.L.S. +4 more
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, 2013 The prevalence of virulence and cytolethal distending toxin (Cdt) genes was investigated in isolates of Campylobacter jejuni, C. coli, C. lanienae and C. lari originated from intestinal contents and gall bladders of clinically healthy cattle.
Acik, M. N. +4 more
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Sequence Variability of P2-Like Prophage Genomes Carrying the Cytolethal Distending Toxin V Operon in Escherichia coli O157 [PDF]
, 2013 Cytolethal distending toxins (CDT) are potent cytotoxins of several Gram-negative pathogenic bacteria, including Escherichia coli, in which five types (CDT-I to CDT-V) have been identified so far.
Dobrindt, Ulrich +4 more
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Impact of CDT Toxin on Human Diseases
Toxins, 2016 Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the ...
Tiphanie Faïs +4 more
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A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses
The Scientific World Journal, 2001 Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop
Maria Lara-Tejero
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Characterization of putative cholesterol recognition/interaction amino acid consensus-like motif of Campylobacter jejuni cytolethal distending toxin C. [PDF]
PLoS ONE, 2013 Cytolethal distending toxin (CDT) produced by Campylobacter jejuni comprises a heterotrimeric complex formed by CdtA, CdtB, and CdtC. Among these toxin subunits, CdtA and CdtC function as essential proteins that mediate toxin binding to cytoplasmic ...
Chih-Ho Lai +7 more
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Frontiers in Cellular and Infection Microbiology, 2017 Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion.
Rachid A. El-Aouar Filho +12 more
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