Results 31 to 40 of about 3,428 (189)

Cytolethal Distending Toxin Demonstrates Genotoxic Activity in a Yeast Model [PDF]

Infection and Immunity, 2001
ABSTRACTCytolethal distending toxins (CDTs) are multisubunit proteins produced by a variety of bacterial pathogens that cause enlargement, cell cycle arrest, and apoptosis in mammalian cells. While their function remains uncertain, recent studies suggest that they can act as intracellular DNases in mammalian cells. Here we establish a novel yeast model
D C, Hassane, R B, Lee, M D, Mendenhall, C L, Pickett   +3 more
openaire   +3 more sources

Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation [PDF]

Frontiers in Immunology, 2019
The receptor for advanced glycation end products (RAGE) interacts with various molecules in the cell membrane to induce an inflammatory response. The cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB ...
Hwai-Jeng Lin, Hwai-Jeng Lin, Zhi-Pei Jiang, Zhi-Pei Jiang, Horng-Ren Lo, Chun-Lung Feng, Chun-Lung Feng, Chih-Jung Chen, Chia-Yu Yang, Chia-Yu Yang, Mei-Zi Huang, Hui-Yu Wu, Yu-An Chen, Yu Chen, Cheng-Hsun Chiu, Cheng-Hsun Chiu, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai   +19 more
doaj   +2 more sources

Corrigendum: Revisiting bacterial cytolethal distending toxin structure and function [PDF]

Frontiers in Cellular and Infection Microbiology
Henry Chen, Claire J. Ang, Molly K. Crowder, William M. Brieher, Steven R. Blanke, Steven R. Blanke, Steven R. Blanke   +6 more
doaj   +2 more sources

<i>Campylobacter jejuni</i> extracellular vesicles harboring cytolethal distending toxin bind host cell glycans and induce cell cycle arrest in host cells. [PDF]

Microbiol Spectr
Cytolethal distending toxins (CDTs) are released by Gram-negative pathogens into the extracellular medium as free toxin or associated with extracellular vesicles (EVs), commonly known as outer membrane vesicles (OMVs).
Le LHM, Elgamoudi B, Colon N, Cramond A, Poly F, Ying L, Korolik V, Ferrero RL.   +7 more
europepmc   +2 more sources

The Biology of the Cytolethal Distending Toxins [PDF]

Toxins, 2011
The cytolethal distending toxins (CDTs), produced by a variety of Gram-negative pathogenic bacteria, are the first bacterial genotoxins described, since they cause DNA damage in the target cells. CDT is an A-B2 toxin, where the CdtA and CdtC subunits are required to mediate the binding on the surface of the target cells, allowing internalization of the
Lina Guerra, Ximena Cortes-Bratti, Riccardo Guidi, Teresa Frisan   +3 more
openaire   +3 more sources

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Delivery, structure, and function of bacterial genotoxins

Virulence, 2022
Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells.
Liaoqi Du, Jeongmin Song
doaj   +1 more source

Inflammatory and Bone Remodeling Responses to the Cytolethal Distending Toxins [PDF]

Cells, 2014
The cytolethal distending toxins (CDTs) are a family of exotoxins produced by a wide range of Gram-negative bacteria. They are known for causing genotoxic stress to the cell, resulting in growth arrest and eventually apoptotic cell death. Nevertheless, there is evidence that CDTs can also perturb the innate immune responses, by regulating ...
Belibasakis, Georgios N, Bostanci, Nagihan   +1 more
openaire   +4 more sources

Molecular Docking Study for Inhibitors of Aggregatibacter actinomycetamcomitans Toxins in Treatment of Aggressive Perioodontitis [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Periodontitis is a chronic inflammatory disease of the periodontal tissues causing periodontal attachment loss and destruction of the alveolar bone which leads to mobility and loss of teeth.
Makesh Raj.L.S., Jude. J., Kannan.I., Sai Krishna.P., Shankar.K.A.   +4 more
doaj   +1 more source

A Journey of Cytolethal Distending Toxins through Cell Membranes [PDF]

Frontiers in Cellular and Infection Microbiology, 2016
The multifunctional role of lipids as structural components of membranes, signaling molecules, and metabolic substrates makes them an ideal partner for pathogens to hijack host cell processes for their own survival. The properties and composition of unique membrane micro-domains such as membrane rafts make these regions a natural target for pathogens ...
Boesze-Battaglia, Kathleen, Alexander, Desiree, Dlakić, Mensur, Shenker, Bruce J.   +3 more
openaire   +5 more sources