Results 31 to 40 of about 2,764 (156)

Cytolethal distending toxin: creating a gap in the cell cycle [PDF]

Journal of Medical Microbiology, 2005
Cytolethal distending toxin (CDT) is a novel bacterial toxin that is produced by a variety of pathogenic bacteria. The mechanism of cytotoxicity of CDT is unique in that it enters into eukaryotic cells and breaks double-stranded DNA. This initiates the cell's own DNA damage-response mechanisms, resulting in the arrest of the cell cycle at the G2/M ...
Wendy, Heywood, Brian, Henderson, Sean P, Nair   +2 more
openaire   +2 more sources

A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses

The Scientific World Journal, 2001
Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop
Maria Lara-Tejero
doaj   +1 more source

Characterization of putative cholesterol recognition/interaction amino acid consensus-like motif of Campylobacter jejuni cytolethal distending toxin C. [PDF]

PLoS ONE, 2013
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni comprises a heterotrimeric complex formed by CdtA, CdtB, and CdtC. Among these toxin subunits, CdtA and CdtC function as essential proteins that mediate toxin binding to cytoplasmic ...
Chih-Ho Lai, Cheng-Kuo Lai, Ying-Ju Lin, Chiu-Lien Hung, Chia-Han Chu, Chun-Lung Feng, Chia-Shuo Chang, Hong-Lin Su   +7 more
doaj   +1 more source

Biogenesis of the Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin Holotoxin [PDF]

Infection and Immunity, 2006
ABSTRACT The cell cycle G 2 /M specific inhibitor cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans is composed of CdtA, CdtB, and CdtC coded on the cdtA , cdtB , and cdtC genes that ...
Ueno, Y, Ohara, M, Kawamoto, T, Fujiwara, Toru, Komatsuzawa, H, Oswald, Eric, Sugai, M   +6 more
openaire   +4 more sources

Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Frontiers in Cellular and Infection Microbiology, 2017
Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion.
Rachid A. El-Aouar Filho, Rachid A. El-Aouar Filho, Aurélie Nicolas, Thiago L. De Paula Castro, Martine Deplanche, Vasco A. De Carvalho Azevedo, Pierre L. Goossens, Frédéric Taieb, Gerard Lina, Gerard Lina, Gerard Lina, Yves Le Loir, Nadia Berkova   +12 more
doaj   +1 more source

Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT. [PDF]

PLoS Pathogens, 2005
Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (CdtB)
Dragana Nesic, C Erec Stebbins
doaj   +2 more sources

Trans-Cinnamaldehyde, Carvacrol, and Eugenol Reduce Campylobacter jejuni Colonization Factors and Expression of Virulence Genes in Vitro

Frontiers in Microbiology, 2017
Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal ...
Dan J. Donoghue, Abhinav Upadhyay, Komala Arsi, Basanta R. Wagle, Indu Upadhyaya, Sandip Shrestha, Ann M. Donoghue   +6 more
doaj   +1 more source

Reconstitution and Purification of Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans [PDF]

Microbiology and Immunology, 2001
AbstractCytolethal distending toxin (CDT) has been found in various pathogenic bacterial species and causes a cell distending and a G2 arrest against eukaryotic cells. All the cdtABC genes, which encode CDT, are known to be required for the CDT activities although the CDT holotoxin structure has not been elucidated.
K, Saiki, K, Konishi, T, Gomi, T, Nishihara, M, Yoshikawa   +4 more
openaire   +2 more sources

Haemophilus parasuis encodes two functional cytolethal distending toxins: CdtC contains an atypical cholesterol recognition/interaction region. [PDF]

PLoS ONE, 2012
Haemophilus parasuis is the causative agent of Glässer's disease of pigs, a disease associated with fibrinous polyserositis, polyarthritis and meningitis. We report here H.
Mingguang Zhou, Qiang Zhang, Jianping Zhao, Meilin Jin   +3 more
doaj   +1 more source

Introns in the Cytolethal Distending Toxin Gene ofActinobacillus actinomycetemcomitans [PDF]

Journal of Bacteriology, 2005
ABSTRACTIn eukaryotic cells, genes are interrupted by intervening sequences called introns. Introns are transcribed as part of a precursor RNA that is subsequently removed by splicing, giving rise to mature mRNA. However, introns are rarely found in bacteria.Actinobacillus actinomycetemcomitansis a periodontal pathogen implicated in aggressive forms of
Kai, S.T., Keang, P.S., Ong, G.
openaire   +2 more sources