Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT. [PDF]
PLoS Pathogens, 2005 Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (CdtB)
Dragana Nesic, C Erec Stebbins
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Characterization and serotype distribution of Aggregatibacter actinomycetemcomitans detected in a population of periodontitis patients in Spain. [PDF]
, 2009 Objective: To investigate the serotype distribution of Aggregatibacter actinomycetemcomitans (A. a.) and the polymorphism of the genes that codify the leukotoxin (ltx) and the operon of the cytolethal distending toxin (cdt) in periodontitis patients in ...
Blasi, Andrea
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Frontiers in Microbiology, 2017 Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal ...
Dan J. Donoghue +6 more
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Journal of the Pakistan Medical AssociationObjective: To identify possible tests along with their accuracies that may be used to diagnose irritable bowel syndrome. Method: The systematic review comprised literature search on Cochrane Library, PubMed, Science Direct and Elsevier databases for ...
Misha Mansoor +5 more
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Haemophilus parasuis encodes two functional cytolethal distending toxins: CdtC contains an atypical cholesterol recognition/interaction region. [PDF]
PLoS ONE, 2012 Haemophilus parasuis is the causative agent of Glässer's disease of pigs, a disease associated with fibrinous polyserositis, polyarthritis and meningitis. We report here H.
Mingguang Zhou +3 more
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A possible role of urinary genotoxic Escherichia coli in prostate cancer in Nigerian patients
BMC Research NotesObjective Infection and inflammation are potential initiating factors for the development and progression of prostate cancer. This study investigated the presence of bacterial genotoxins; colibactin (clb) and cytolethal distending toxin (cdt) in ...
Sharon O. Akinpelu +2 more
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Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralising antibodies induced during human infection but not chicken colonisation [PDF]
, 2005 The cytolethal distending toxin (CDT) of Campylobacter jejuni was detectable, using an in vitro assay, in most but not all of 24 strains tested. The reason for the absence of toxin activity in these naturally occurring CDT-negative C.
Ridley, A +6 more
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Escherichia albertii in Wild and Domestic Birds
Emerging Infectious Diseases, 2010 Escherichia albertii has been associated with diarrhea in humans but not with disease or infection in animals. However, in December 2004, E. albertii was found, by biochemical and genetic methods, to be the probable cause of death for redpoll finches ...
J. Lindsay Oaks +12 more
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E. coli and colon cancer : Is mutY a culprit? [PDF]
, 2013 Peer ...
Khan, Abdul Arif, Cash, Phillip
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Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation [PDF]
, 1997 Cytolethal distending toxins (CDT) constitute an emerging heterogeneous family of bacterial toxins whose common biological property is to inhibit the proliferation of cells in culture by blocking their cycle at G2/M phase.
Pérès, Sylvie Yvonne +10 more
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