Results 1 to 10 of about 3,008 (111)

Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer

Biomedicines, 2021
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA).
Chih-Ho Lai, Ho Lin, Jer-Tsong Hsieh
exaly   +3 more sources

The Role of clbF in the Pathogenicity of Avian Pathogenic Escherichia coli [PDF]

Veterinary Sciences
The genotoxin colibactin, a complex secondary metabolite, targets eukaryotic cell cycle machinery and contributes to neonatal sepsis and meningitis.
Meng Wu, Haitao Wu, Ling Li, Pan Hao, Peili Wang   +4 more
doaj   +2 more sources

MutAIverse: an AI-powered, mechanism-backed platform for discovering novel DNA adducts and their precursor genotoxins [PDF]

Journal of Cheminformatics
Genotoxin exposure leads to DNA adduct formation, potentially causing mutations if unrepaired. Current DNA adductomics platforms or analytical workflows are limited by incomplete spectral libraries, reliance on experimentally validated adducts, limited ...
Shiva Satija, Sanjay Kumar Mohanty, Sachin B. Jorvekar, Anshul Verma, Saveena Solanki, Vishakha Gautam, Sakshi Arora, Aayushi Mittal, Arushi Sharma, Sonam Chauhan, Subhadeep Duari, Suvendu Kumar, Avdhesh Rai, Anupam Das, Kaberi Kakati, Kishore Das, Anupam Sarma, Juhi Tayal, Debarka Sengupta, Anurag Mehta, Roshan M. Borkar, Gaurav Ahuja   +21 more
doaj   +2 more sources

Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations

Cell Reports, 2023
Summary: The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis.
Ellen L. Zechner, Sandra Raffl
exaly   +3 more sources

Apurinic/apyrimidinic endonuclease 1 prevents oxidative DNA damage in intestinal epithelial cells induced by genotoxic Escherichia coli NC101 [PDF]

Redox Biology
Background: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that regulates host responses to oxidative stress. We investigated its role in controlling DNA damage following infection with a genotoxic intestinal microbe.
Lindsay D. Butcher, Gerco den Hartog, Amber L. Ablack, Mason Matsubara, Leonid M. Rovner, David Rios-Covian, Taren Thron, Sarkis K. Mazmanian, Jailal N.G. Ablack, Thaddeus Stappenbeck, Lars Eckmann, Tadahide Izumi, Alina Tirla, Kevin M. Wernke, Seth B. Herzon, Michael W. Dougherty, Christian Jobin, Hiroshi Kiyono, Peter B. Ernst, Sheila E. Crowe   +19 more
doaj   +2 more sources

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Nature Communications
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory phenotype (SASP) by damaging mitochondrial ...
Chun-Jung Ko, Han-Yi Chen, Shu-Jung Chang   +2 more
exaly   +2 more sources

Microbial genotoxin-elicited host DNA mutations related to mitochondrial dysfunction, a momentous contributor for colorectal carcinogenesis [PDF]

mSystems
Gut microbe dysbiosis increases repetitive inflammatory responses, leading to an increase in the incidence of colorectal cancer. Recent studies have revealed that specific microbial species directly instigate mutations in the host nucleus DNA, thereby ...
Xue Yang, Yumeng Gan, Yuting Zhang, Zhongjian Liu, Jiawei Geng, Wenxue Wang   +5 more
doaj   +2 more sources

Intestinal bacteria and colorectal cancer: etiology and treatment

Gut Microbes, 2023
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecular signaling ...
Michael W. Dougherty, Christian Jobin
doaj   +1 more source

Cyclomodulins and Hemolysis in E. coli as Potential Low-Cost Non-Invasive Biomarkers for Colorectal Cancer Screening

Life, 2021
The frequent occurrence of E. coli positive for cyclomodulins such as colibactin (CLB), the cytotoxic necrotizing factor (CNF), and the cytolethal distending factor (CDT) in colorectal cancer (CRC) patients published so far provides the opportunity to ...
Kristýna Mezerová, Lubomír Starý, Pavel Zbořil, Ivo Klementa, Martin Stašek, Petr Špička, Pavel Skalický, Vladislav Raclavský   +7 more
doaj   +1 more source

Shining a Light on Colibactin Biology

Toxins, 2021
Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease
Michael W. Dougherty, Christian Jobin
doaj   +1 more source