The Role of clbF in the Pathogenicity of Avian Pathogenic Escherichia coli [PDF]
Veterinary SciencesThe genotoxin colibactin, a complex secondary metabolite, targets eukaryotic cell cycle machinery and contributes to neonatal sepsis and meningitis.
Meng Wu +4 more
doaj +2 more sources
Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer
Biomedicines, 2021 Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA).
Chih-Ho Lai, Ho Lin, Jer-Tsong Hsieh
exaly +3 more sources
D-Serine reduces the expression of the cytopathic genotoxin colibactin
Microbial Cell, 2023 Some Escherichia coli strains harbour the pks island, a 54 kb genomic island en-coding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chro-mosomal instability.
Eric Oswald +2 more
exaly +3 more sources
Biosynthesis and bioactivities of microbial genotoxin colibactins
Natural Product Reports, 2022 This review provides an update on biosynthesis and bioactivities of colibactin(s), the long-sought genotoxins produced by the pks island of Escherichia coli .
Zhongrui Li, Pei-Yuan Qian
exaly +4 more sources
Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations
Cell Reports, 2023 Summary: The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis.
Ellen L Zechner
exaly +3 more sources
The Genotoxin Colibactin Shapes Gut Microbiota in Mice [PDF]
mSphere, 2020 The genotoxin colibactin produced by resident bacteria of the gut microbiota may have tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of colibactin on gut microbiota composition and functions remains unknown.
Sophie Tronnet +6 more
doaj +6 more sources
Delivery, structure, and function of bacterial genotoxins
Virulence, 2022 Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells.
Liaoqi Du, Jeongmin Song
doaj +3 more sources
Cellular Senescence Triggered by Food and Environmental Genotoxins [PDF]
Int J Mol SciCellular senescence (CSEN) is caused by a variety of factors that trigger complex molecular pathways. These include telomere shortening, oncogene activation and replicative stress, as well as DNA damage caused by genotoxic anticancer drugs and endogenous and exogenous genotoxins.
Bernd Kaina +2 more
europepmc +4 more sources
Microbial genotoxin-elicited host DNA mutations related to mitochondrial dysfunction, a momentous contributor for colorectal carcinogenesis [PDF]
mSystemsGut microbe dysbiosis increases repetitive inflammatory responses, leading to an increase in the incidence of colorectal cancer. Recent studies have revealed that specific microbial species directly instigate mutations in the host nucleus DNA, thereby ...
Xue Yang +5 more
doaj +2 more sources
Mechanisms of genotoxin-induced transcription and hypermutation in
Cancer Cell International, 2006 It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulates p53 transcription and the formation of ...
Burkala Evan +5 more
doaj +3 more sources