Results 1 to 10 of about 2,916 (131)
The Role of clbF in the Pathogenicity of Avian Pathogenic Escherichia coli [PDF]
Veterinary SciencesThe genotoxin colibactin, a complex secondary metabolite, targets eukaryotic cell cycle machinery and contributes to neonatal sepsis and meningitis.
Meng Wu +4 more
doaj +2 more sources
Bacterial Genotoxin-Coated Nanoparticles for Radiotherapy Sensitization in Prostate Cancer
Biomedicines, 2021 Prostate cancer (PCa) is one of the most commonly diagnosed cancers in men and usually becomes refractory because of recurrence and metastasis. CD44, a transmembrane glycoprotein, serves as a receptor for hyaluronic acid (HA).
Chun-Jung Lin +2 more
exaly +3 more sources
Microbiota-derived genotoxin tilimycin generates colonic stem cell mutations
Cell Reports, 2023 Summary: The DNA-alkylating metabolite tilimycin is a microbial genotoxin. Intestinal accumulation of tilimycin in individuals carrying til+ Klebsiella spp. causes apoptotic erosion of the epithelium and colitis.
Christian Lembacher-Fadum +1 more
exaly +3 more sources
The DNA helicase RTEL1 is involved in the repair of replicative DNA damage independently of the alternative end joining and the DNA-protein cross-link repair pathways in Arabidopsis. [PDF]
Plant JSUMMARY Recent studies indicate that the Fe–S DNA helicase RTEL1 plays an important role in replicative DNA repair in plants. Since non‐homologous end joining (NHEJ) and DNA–protein cross‐link (DPC) repair also protect DNA replication in Arabidopsis, we set out to further define the interactions of RTEL1 and these pathways by analyzing double mutants ...
Goldkuhle L +4 more
europepmc +2 more sources
Nature CommunicationsBacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory phenotype (SASP) by damaging mitochondrial ...
Wan-Chen Hsieh +2 more
exaly +2 more sources
Microbial genotoxin-elicited host DNA mutations related to mitochondrial dysfunction, a momentous contributor for colorectal carcinogenesis [PDF]
mSystemsGut microbe dysbiosis increases repetitive inflammatory responses, leading to an increase in the incidence of colorectal cancer. Recent studies have revealed that specific microbial species directly instigate mutations in the host nucleus DNA, thereby ...
Xue Yang +5 more
doaj +2 more sources
Intestinal bacteria and colorectal cancer: etiology and treatment
Gut Microbes, 2023 The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecular signaling ...
Michael W. Dougherty, Christian Jobin
doaj +1 more source
Life, 2021 The frequent occurrence of E. coli positive for cyclomodulins such as colibactin (CLB), the cytotoxic necrotizing factor (CNF), and the cytolethal distending factor (CDT) in colorectal cancer (CRC) patients published so far provides the opportunity to ...
Kristýna Mezerová +7 more
doaj +1 more source
Shining a Light on Colibactin Biology
Toxins, 2021 Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease
Michael W. Dougherty, Christian Jobin
doaj +1 more source
Molecules, 2023 Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible.
Hanna Nikolaichuk +2 more
doaj +1 more source