Results 1 to 10 of about 4,161 (127)

Oxygen concentration modulates colibactin production

Gut Microbes, 2023
Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite.
Nadege Bossuet-Greif, Camille V Chagneau, Min Tang-Fichaux   +2 more
exaly   +3 more sources

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

Neoplasia, 2023
Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E.
Michael W. Dougherty, Rafael Valdés-Mas, Kevin M. Wernke, Raad Z. Gharaibeh, Ye Yang, Jason O. Brant, Alberto Riva, Marcus Muehlbauer, Eran Elinav, Jens Puschhof, Seth B. Herzon, Christian Jobin   +11 more
exaly   +3 more sources

The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links [PDF]

Nature Communications
Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the development of colorectal cancer. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross ...
Maria Altshuller, Xu He, Elliot J. MacKrell, Kevin M. Wernke, Yougant Airan, Joel W. H. Wong, Selene Sellés-Baiget, Ting-Yu Wang, Tsui-Fen Chou, Julien P. Duxin, Emily P. Balskus, Seth B. Herzon, Daniel R. Semlow   +12 more
doaj   +2 more sources

Colibactin in avian pathogenic Escherichia coli contributes to the development of meningitis in a mouse model

Virulence, 2021
Colibactin is synthesized by a 54-kb genomic island, leads to toxicity in eukaryotic cells, and plays a vital role in many diseases, including neonatal sepsis and meningitis.
Haoran Zhong, Heng Wang, Guoqiang Zhu
exaly   +2 more sources

Shining a Light on Colibactin Biology

Toxins, 2021
Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease
Michael W Dougherty, Christian Jobin, Jobin Christian   +2 more
exaly   +3 more sources

Colibactin: More Than a New Bacterial Toxin

Toxins, 2018
Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006.
Julien Delmas, Nicolas Barnich, Richard Bonnet   +2 more
exaly   +3 more sources

Colibactin (pks) carriage in Escherichia coli is associated with lineage restriction, reduced plasmid burden, and lower antimicrobial resistance [PDF]

Frontiers in Microbiology
The colibactin pks genomic island of Escherichia coli is a chromosomally integrated secondary metabolite locus implicated in host–microbe interactions and colorectal carcinogenesis. Although pks distribution has been linked to specific E.
Adel Azour, Ghassan M. Matar, Ghassan M. Matar, Ghassan M. Matar, Melhem Bilen, Melhem Bilen, Melhem Bilen   +6 more
doaj   +2 more sources

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis

Gut Microbes, 2023
Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis.
Hilmar Berger, Lichao Liu, Hans-Joachim Mollenkopf   +2 more
exaly   +3 more sources

DNA cross-link repair deficiency enhances human cell sensitivity to colibactin-induced genotoxicity [PDF]

Genes and Environment
Introduction Colibactin is a small genotoxic molecule of polyketide produced by a subset of enteric bacteria including certain Escherichia coli (E. coli) harbored in the human gut microbiota.
Masanobu Kawanishi, Osamu Tsubohira, Ai Ueshima, Yuuta Hisatomi, Yoshimitsu Oda, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi, Takashi Yagi, Kenji Watanabe   +11 more
doaj   +2 more sources

The Role of clbF in the Pathogenicity of Avian Pathogenic Escherichia coli [PDF]

Veterinary Sciences
The genotoxin colibactin, a complex secondary metabolite, targets eukaryotic cell cycle machinery and contributes to neonatal sepsis and meningitis.
Meng Wu, Haitao Wu, Ling Li, Pan Hao, Peili Wang   +4 more
doaj   +2 more sources