The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Neoplasia, 2023 Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E.
Michael W. Dougherty +11 more
exaly +3 more sources
Virulence, 2021 Colibactin is synthesized by a 54-kb genomic island, leads to toxicity in eukaryotic cells, and plays a vital role in many diseases, including neonatal sepsis and meningitis.
Heng Wang, Luying Cui, Pengpeng Xia
exaly +2 more sources
Colibactin: More Than a New Bacterial Toxin
Toxins, 2018 Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006.
Nicolas Barnich +2 more
exaly +3 more sources
Shining a Light on Colibactin Biology
Toxins, 2021 Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease
Christian Jobin, Michael W Dougherty
exaly +3 more sources
Exploratory analysis of genotoxic Escherichia coli and Helicobacter pylori virulence in gastrointestinal carcinogenesis. [PDF]
AMB ExpressGastrointestinal cancers remain among the leading causes of cancer-related mortality worldwide. Beyond environmental and hereditary determinants, increasing evidence suggests that the gut microbiota may contribute to carcinogenesis through persistent ...
Karaman T +8 more
europepmc +2 more sources
Towards a safer probiotic: <i>clbD</i> deletion attenuates EcN-induced DNA damage responses and epithelial inflammatory transcriptional responses. [PDF]
Front Cell Infect MicrobiolEscherichia coli Nissle 1917 (EcN) is widely used as a probiotic and engineering chassis, but its carriage of the pks genomic island raises safety concerns related to the genotoxin colibactin.
Chen WM +5 more
europepmc +2 more sources
Gut Microbes, 2023 Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis.
Hilmar Berger, Lichao Liu, Till Strowig
exaly +3 more sources
Colibactin (<i>pks</i>) carriage in <i>Escherichia coli</i> is associated with lineage restriction, reduced plasmid burden, and lower antimicrobial resistance. [PDF]
Front MicrobiolThe colibactin pks genomic island of Escherichia coli is a chromosomally integrated secondary metabolite locus implicated in host–microbe interactions and colorectal carcinogenesis. Although pks distribution has been linked to specific E.
Azour A, Matar GM, Bilen M.
europepmc +2 more sources
The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links. [PDF]
Nat CommunColibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the development of colorectal cancer. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross ...
Altshuller M +12 more
europepmc +2 more sources
DNA cross-link repair deficiency enhances human cell sensitivity to colibactin-induced genotoxicity. [PDF]
Genes EnvironIntroduction Colibactin is a small genotoxic molecule of polyketide produced by a subset of enteric bacteria including certain Escherichia coli (E. coli) harbored in the human gut microbiota.
Kawanishi M +11 more
europepmc +2 more sources