Results 21 to 30 of about 5,208 (185)
mSystemsColibactin, a nonribosomal peptide/polyketide produced by pks+ Enterobacteriaceae, is a virulence factor and putative carcinogen that damages DNA by interstrand crosslinking (ICL).
Charlie Bayne +3 more
doaj +2 more sources
Colibactin-induced damage in bacteria is cell contact independent
mBioThe bacterial toxin colibactin, produced primarily by the B2 phylogroup of Escherichia coli, underlies some cases of colorectal cancers. Colibactin crosslinks DNA and induces genotoxic damage in both mammalian and bacterial cells.
Emily Lowry, Amir Mitchell
doaj +4 more sources
The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin
EcoSal Plus, 2016 While the DNA damage induced by ionizing radiation and by many chemical compounds and drugs is well characterized, the genotoxic insults inflicted by bacteria are only scarcely documented.
Petit, Claude +3 more
core +4 more sources
Synthesis and Biological Evaluation of Colibactin Derivatives. [PDF]
ACS Chem BiolColibactin is a pseudo-C2-symmetric gut microbiome metabolite that induces DNA interstrand cross-links and plays a causal role in colorectal cancer. Since efforts to isolate colibactin have not been successful, we developed colibactin 742 (3a/b) as a stable colibactin mimetic. However, colibactin 742 (3a/b) exists as a mixture of ring and chain isomers,
Airan Y +7 more
europepmc +3 more sources
The colibactin warhead crosslinks DNA [PDF]
Nature Chemistry, 2015 Members of the human microbiota are increasingly being correlated to human health and disease states, but the majority of the underlying microbial metabolites that regulate host-microbe interactions remain largely unexplored. Select strains of Escherichia coli present in the human colon have been linked to the initiation of inflammation-induced ...
Vizcaino, Maria I., Crawford, Jason M.
openaire +2 more sources
mBio, 2022 Bacteria have to process several levels of gene regulation and coordination of interconnected regulatory networks to ensure the most adequate cellular response to specific growth conditions.
Nadine Rehm +13 more
doaj +1 more source
A Mechanistic Model for Colibactin-Induced Genotoxicity [PDF]
Journal of the American Chemical Society, 2016 Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. clb+ E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917 ...
Alan R, Healy +4 more
openaire +2 more sources
Biosynthesis and bioactivities of microbial genotoxin colibactins
Natural Product Reports, 2022 This review provides an update on biosynthesis and bioactivities of colibactin(s), the long-sought genotoxins produced by the pks island of Escherichia coli .
Jian-Wei Tang +4 more
openaire +3 more sources
The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction
Frontiers in Pharmacology, 2022 The human microbiota produces molecules that are evolved to interact with the diverse cellular machinery of both the host and microbes, mediating health and diseases.
Walaa K. Mousa, Walaa K. Mousa
doaj +1 more source
Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations. [PDF]
, 2021 The bacterial genotoxin colibactin interferes with the eukaryotic cell cycle by causing dsDNA breaks. It has been linked to bacterially induced colorectal cancer in humans. Colibactin is encoded by a 54 kb genomic region in Enterobacteriaceae.
Müller, Rolf +7 more
core +1 more source