Results 21 to 30 of about 4,211 (161)

Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli

mBio, 2022
Bacteria have to process several levels of gene regulation and coordination of interconnected regulatory networks to ensure the most adequate cellular response to specific growth conditions.
Nadine Rehm, Alexander Wallenstein, Marla Keizers, Stefan Homburg, Giuseppe Magistro, Camille V. Chagneau, Hanna Klimek, Olga Revelles, Emmanuelle Helloin, Johannes Putze, Jean-Philippe Nougayrède, Sören Schubert, Eric Oswald, Ulrich Dobrindt   +13 more
doaj   +1 more source

The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction

Frontiers in Pharmacology, 2022
The human microbiota produces molecules that are evolved to interact with the diverse cellular machinery of both the host and microbes, mediating health and diseases.
Walaa K. Mousa, Walaa K. Mousa
doaj   +1 more source

Structural basis of colibactin activation by the ClbP peptidase

Nature Chemical Biology, 2022
AbstractColibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after export to the periplasm.
José A. Velilla, Matthew R. Volpe, Grace E. Kenney, Richard M. Walsh, Emily P. Balskus, Rachelle Gaudet   +5 more
openaire   +4 more sources

Phosphopantetheinyl transferase ClbA contributes to the virulence of avian pathogenic Escherichia coli in meningitis infection of mice.

PLoS ONE, 2022
Avian pathogenic Escherichia coli (APEC), which has potential zoonotic risk, can cause severe systemic infections such as septicemia and meningitis in poultry.
Xia Meng, Yanfei Chen, Peili Wang, Pengpeng Xia, Jinqiu Wang, Mengping He, Chunhong Zhu, Heng Wang, Guoqiang Zhu   +8 more
doaj   +1 more source

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

mSphere, 2020
Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for
Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu   +5 more
doaj   +1 more source

Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains

BMC Cancer, 2021
Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island.
Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt, Manuela M. Santos   +6 more
doaj   +1 more source

Correlation Between Antimicrobial Resistance, Virulence Determinants and Biofilm Formation Ability Among Extraintestinal Pathogenic Escherichia coli Strains Isolated in Catalonia, Spain

Frontiers in Microbiology, 2022
Escherichia coli is a well-characterized bacterium highly prevalent in the human intestinal tract and the cause of many important infections. The aim of this study was to characterize 376 extraintestinal pathogenic E.
Victoria Ballén, Yaiza Gabasa, Carlos Ratia, Melany Sánchez, Sara Soto   +4 more
doaj   +1 more source

Structure elucidation of colibactin [PDF]

, 2019
Abstract Colibactin is a gut microbiome metabolite of unknown structure that has been implicated in colorectal cancer formation. Several studies now suggest that the tumorgenicity of colibactin derives from interstrand cross-linking of host DNA.
Xue, Mengzhao, Kim, Chung Sub, Healy, Alan R., Wernke, Kevin M., Wang, Zhixun, Frischling, Madeline C., Shine, Emilee E., Wang, Weiwei, Herzon, Seth B., Crawford, Jason M.   +9 more
openaire   +1 more source

Chemiluminescent Probes Allow for the Rapid Identification of Colibactin-Producing Bacteria. [PDF]

JACS Au
ABSTRACT The pks (or clb ) gene cluster, which produces the genotoxic natural product colibactin, is encoded by human gut Enterobacteriaceae , including many commensal strains of E. coli
Aguilar Ramos MA, Gutkin S, David M, Shabat D, Balskus EP.   +4 more
europepmc   +3 more sources

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.

PLoS Pathogens, 2022
Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing.
Jun Jie Wong, Foo Kiong Ho, Pei Yi Choo, Kelvin K L Chong, Chee Meng Benjamin Ho, Ramesh Neelakandan, Damien Keogh, Timothy Barkham, John Chen, Chuan Fa Liu, Kimberly A Kline   +10 more
doaj   +1 more source