Results 41 to 50 of about 4,211 (161)

L-tryptophan and copper interactions linked to reduced colibactin genotoxicity in pks+ Escherichia coli

mSystems
Colibactin, a nonribosomal peptide/polyketide produced by pks+ Enterobacteriaceae, is a virulence factor and putative carcinogen that damages DNA by interstrand crosslinking (ICL).
Charlie Bayne, Magali Boutard, Tom Zaplana, Andrew C. Tolonen   +3 more
doaj   +1 more source

Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population.

PLoS ONE, 2022
Colorectal cancer (CRC) is the third most prevalent cause of tumorigenesis and several pathogenic bacteria have been correlated with aggressive cases of cancer i.e., genotoxin (colibactin) producing Escherichia coli (E. coli).
Habiba Tariq, Zobia Noreen, Aftab Ahmad, Laraib Khan, Mashhood Ali, Muhammad Malik, Aneela Javed, Faisal Rasheed, Alina Fatima, Tanil Kocagoz, Ugur Sezerman, Habib Bokhari   +11 more
doaj   +1 more source

The genotoxin colibactin

Toxicon, 2016
Escherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants are stably colonized by E. coli within a few days after birth. Certain E.
openaire   +3 more sources

Genotoxic Klebsiella pneumoniae in Taiwan. [PDF]

PLoS ONE, 2014
BACKGROUND: Colibactin is a nonribosomal peptide-polyketide synthesized by multi-enzyme complexes encoded by the pks gene cluster. Colibactin-producing Escherichia coli have been demonstrated to induce host DNA damage and promote colorectal cancer (CRC ...
Yi-Chyi Lai, Ann-Chi Lin, Ming-Ko Chiang, Yu-Han Dai, Chih-Chieh Hsu, Min-Chi Lu, Chun-Yi Liau, Ying-Tsong Chen   +7 more
doaj   +1 more source

Presence of Polyketide Synthase (PKS) Gene and Counterpart Virulence Determinants in Klebsiella pneumoniae Strains Enhances Colorectal Cancer Progression In-Vitro

Microorganisms, 2023
Klebsiella pneumoniae (K. pneumoniae) colonizes the human gut and is a causative factor of pyogenic liver abscess (PLA). Retrospective studies conducted on K.
Christina Parvinder Kaur, Thevambiga Iyadorai, Cynthia Sears, April Camilla Roslani, Jamuna Vadivelu, Chandramathi Samudi   +5 more
doaj   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, EarlyView.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review

Biomedical Papers, 2022
Appropriate screening of early asymptomatic cases can reduce the disease burden and mortality rate of sporadic colorectal cancer (CRC) significantly. Currently, fecal occult blood testing (FOBT) is able to detect up to 80% of ­asymptomatic cases in the ...
Kristyna Mezerova, Vladislav Raclavsky, Lubomir Stary   +2 more
doaj   +1 more source

Incidence Trends of Early‐Onset Colorectal Cancer in Germany: A Registry‐Based Study From 2003 to 2023

International Journal of Cancer, EarlyView.
The evidence on the rising incidence of colorectal cancer among adults below 50 years of age largely stems from the United States. Using high‐quality cancer registry data for the 2003–2023 period in Germany, this study found a moderate increase of early‐onset colorectal cancer incidence that was limited to those aged 20–39 years and more pronounced ...
Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller‐Nordhorn, the ALSTER Working Group, Josephine Kanbach, Sabine Luttmann, Meike Ressing, Cécile Ronckers, Soo‐Zin Kim‐Wanner, Alice Nennecke, Frederik Peters, Klaus Kraywinkel, Roxana Müller‐Eberstein, Hannah Baltus, Paula Grieger, Antje Schliemann, Annika Waldmann   +20 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source