Results 51 to 60 of about 4,207 (127)

Pediatric Colorectal Cancer in Africa: A Multicenter Study on Epidemiology, Management, and Outcomes Between 2000 and 2023

JGH Open, Volume 10, Issue 7, July 2026.
ABSTRACT Introduction Colorectal cancer (CRC) is increasing in Africa, yet reports in children and adolescents are limited. We describe the epidemiology, management, and survival outcomes of CRC in African children. Methods Retrospective data of children under 19 years diagnosed with CRC between 2000 and 2023 were collected from 14 African countries ...
Jaques van Heerden, Joyce Balagadde‐Kambugu, Veronica Nyakato, Pamela Mwa, Fadhil Geriga, Barnabas Atwiine, Victoria Mwebe Katasi, Sarra Benmiloud, Laila Hessissen, Imène Chabchoub, Leolin Katsidzira, Eno‐Obong Bassey, Gashaw Arega, Ané Büchner, Jan du Plessis, Mark Siboe, Edrick Elias, Mulingilu Isabel Lumeka, Francine Kouya, Vivian Paintsil, Michelle Obat, Sarah Muma, Olufemi Adefehinti, Adeseye Michael Akinsete, Oluwafunmilayo Toyin Fagbemide, Ndeye Khady Ngom, Sara Marouf, Khaled Seddik, Salah Ahmed, Amany Mohamed Ali, Esraa Abdelkeriem, Reem Ragab, Yomna Mohamed, Moatasem Elayadi, on behalf of SIOP Africa Scientific Committee   +34 more
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries

CA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.
Abstract This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends.
Hyuna Sung, Adalberto M. Filho, Mathieu Laversanne, Jacques Ferlay, Rebecca L. Siegel, Isabelle Soerjomataram, Ahmedin Jemal, Freddie Bray   +7 more
wiley   +1 more source

The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer

Frontiers in Microbiology
Escherichia coli is part of the normal flora of the human gut and performs vital functions; however, certain strains can cause disease in the host, impairing gut function and adversely affecting overall health. The pks gene cluster in the E.
Guojing Zhang, Daqing Sun
doaj   +1 more source

Increased Epithelial Oxygenation Links Colitis to an Expansion of Tumorigenic Bacteria

mBio, 2019
Intestinal inflammation is a risk factor for colorectal cancer formation, but the underlying mechanisms remain unknown. Here, we investigated whether colitis alters the colonic microbiota to enhance its cancer-inducing activity.
Stephanie A. Cevallos, Jee-Yon Lee, Connor R. Tiffany, Austin J. Byndloss, Luana Johnston, Mariana X. Byndloss, Andreas J. Bäumler   +6 more
doaj   +1 more source

Fecal Microbiome Alterations in Colorectal Cancer: A Systematic Review of Compositional Changes and Microbial Biomarkers

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Gut microbiome plays a crucial role in colorectal cancer development. The advanced sequencing techniques have the potential to complement current non‐invasive methods for early diagnosis and prevention of colorectal cancer. This includes conducting studies with robust statistical power and consistent, replicable methodologies, taking into consideration
Parvin Askari, Shirin Dashtbin, Tahereh Navidifar, Leila Dadgar‐Zankbar, Arezoo Asadi, Mahsa Ghamari, Parisa Najafi, Shabnam Zeighamy Alamdary, Roghayeh Afifirad, Roya Ghanavati, Atieh Darbandi   +10 more
wiley   +1 more source

Molecular Genetic and Functional Analysis of pks-Harboring, Extra-Intestinal Pathogenic Escherichia coli From India

Frontiers in Microbiology, 2018
Colibactin, a genotoxin, encoded by the pks pathogenicity island of Escherichia coli belonging to the B2 phylogroup has been reported as a determinant of bacterial pathogenicity. The present study was carried out to detect the pks pathogenicity island in
Arya Suresh, Amit Ranjan, Savita Jadhav, Arif Hussain, Sabiha Shaik, Munirul Alam, Ramani Baddam, Lothar H. Wieler, Niyaz Ahmed, Niyaz Ahmed   +9 more
doaj   +1 more source

Gut Microbiota: A Reservoir for Extraintestinal Bacterial Infections in Febrile Term Infants

iLABMED, Volume 4, Issue 2, Page 116-119, June 2026.
Ran Wang, Renqiang Yu
wiley   +1 more source

Determining the Sequence of Two Colibactin Genes, clbN and clbB, in Some Clinical Isolates of E. coli

Medical Journal of Babylon
Background: Escherichia coli is a widespread human-infecting bacterium that can produce the genotoxin colibactin, which is encoded by the pks pathogenicity island and has been reported as a determinant of bacterial virulence.
Noor Ismeal Nasser, Mohammed Sabri Abdul-Razzag, Nadia Mudher AL-Hili   +2 more
doaj   +1 more source