Results 71 to 80 of about 5,208 (185)

Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Dysbiosis of the gastrointestinal microbiome plays a role in carcinogenesis by inducing chronic inflammation, DNA damage, and activation of signaling pathways such as NF‐κB, STAT3, and Wnt/β‐catenin. Microorganisms such as Helicobacter pylori, Fusobacterium nucleatum, and Bacteroides fragilis promote the development of gastrointestinal tumors through ...
Negar Asgari, Mehrasa Asghari, Touraj Farazmandfar   +2 more
wiley   +1 more source

The genotoxin colibactin

, 2014
National audienceEscherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants
Nougayrède, Jean-Philippe
core   +1 more source

Molecular Insights Into Hypervirulent Klebsiella pneumoniae: Identification and Correlation of Virulence Determinant

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Genotypic characterization of 82 clinical K. pneumoniae isolates identified 34 hypervirulent strains. The peg‐344 most strongly associated with hypervirulence (p = 0.0001) but with only 58.8% sensitivity and no signal in over 40% of hvKP isolates, it's a confirmatory marker, not a standalone diagnostic. ABSTRACT Klebsiella pneumoniae is an increasingly
Fathy M. Elkady, Nosiba S. Basher, Mohammed S. Abdulrahman, Amr H. Hashem, Rafik Abdellatif Metwally, Ahmed Abdel Tawab, Ebrahim Saied, Nasir A. Ibrahim, Mohammed Aufy   +8 more
wiley   +1 more source

Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples

, 2019
While high-colibactin-producing Escherichia coli is thought to be associated with colorectal oncogenesis, this study is complicated part due to an inability to isolate colibactin adequately.
Kenji Watanabe (75040), Yuta Tsunematsu (1311840), Ippei Ohnishi (6836180), Noriyuki Miyoshi (2429455), Ryota Tamafune (6836171), Fumihiko Tanioka (3578540), Yuji Iwashita (6836177), Yuichiro Hirayama (1875700), Michio Sato (684819), Keiji Wakabayashi (405453), Michihiro Mutoh (281679), Nobuo Matsuzaki (6836174), Hideki Ishikawa (3666145), Yuko Yoshikawa (78082), Haruhiko Sugimura (245172)   +14 more
core   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor-1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses

Gut Pathogens, 2019
Background The colibactin and cytotoxic necrotizing factor 1 (Cnf 1) are toxins with cell cycle modulating effects that contribute to tumorgenesis and hyperproliferation.
Radwa N. Morgan, Sarra E. Saleh, Hala A. Farrag, Mohammad M. Aboulwafa   +3 more
doaj   +1 more source

Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response

MedComm, Volume 7, Issue 10, October 2026.
Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu, Jie Yu, Ying Chen, Shengfang Ge, Lin Ye, Yefei Wang, Yixiong Zhou, Renbing Jia   +7 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Expression level of colibactin producing genes after removal of the pks loci.

, 2023
Successful removal of the colibactin production loci in Δpks SYNB8802 prevents expression of clbS gene responsible for colibactin resistance (in red). clbS expression is retained in SYNB8802. (XLSX)
Aida Kalantari (6731369), Mylene Perreault (2004913), Lauren A. Renaud (14559642), Mary N. McDonald (14559648), David L. Hava (14559651), Michael J. James (336941), Vincent M. Isabella (14559654), Catherine E. Monahan (14559645)   +7 more
core   +1 more source

An adherent mucus layer attenuates the genotoxic effect of colibactin [PDF]

Cellular Microbiology, 2017
The human gastrointestinal tract is a complex ecosystem in which epithelial cells and microorganisms of the intestinal microbiota live in symbiosis. Certain members of the microbiota, in particular Escherichia coli strains of the B2 phylotype, carry the polyketide synthase-island encoding the genotoxin colibactin.
Christian Reuter, Mona Alzheimer, Heike Walles, Tobias A. Oelschlaeger   +3 more
openaire   +2 more sources