Results 81 to 90 of about 5,208 (185)

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers

Cancer Science, Volume 117, Issue 9, Page 2357-2365, September 2026.
Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima, Kentaro Jingushi, Takuro Saito, Toshihiro Uemura, Akinaru Yamamoto, Nesrine Sassi, Hiromu Horitani, Shunsuke Inoguchi, Yuki Horibe, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Norio Nonomura   +12 more
wiley   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, Volume 73, Issue 6, Page 516-527, September 2026.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Dietary Terpenoids in Advancing Biofilm‐Mediated Cancer Prevention: Antibiofilm Cascade, Molecular Crosstalk, and Nano‐Facilitated Functional Delivery

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Saikat Mazumder, Aditi Dey, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Sudhriti Maity, Navin Kumar, Soumya Pandit, Vaseem Raja, Shubham Sharma, Shashi Prakash Dwivedi, Mithul Rajeev, Juwita Ratna Dewi, Lola Sanayeva, Dilbar Azimova   +14 more
wiley   +1 more source

Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer [PDF]

BACKGROUND AND OBJECTIVE: The etiology of prostate cancer (PC) is multifactorial and poorly understood. It has been suggested that colibactin-producing Escherichia coli positive for the pathogenicity island pks (pks+) initiate cancers via induction of ...
Mootor, Mohammed FE, Wernke, Kevin M, Haas, Roni, Fu, Jianmin, Jobin, Christian, Doris, Molly J, Mohammed, Ghouse, Jordan, Madison, Herzon, Seth B, Al-Hiyari, Sarah, Liss, Michael A, Williamson, Elizabeth A, Gonzalez, Alfredo, Yamaguchi, Takafumi N, Hromas, Robert, Hugh-White, Rupert, Pan, Yu, Wickes, Brian L, Tian, Mao, Patel, Yash, Agrawal, Raag, Boutros, Paul C   +21 more
core   +1 more source

The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer

Frontiers in Microbiology
Escherichia coli is part of the normal flora of the human gut and performs vital functions; however, certain strains can cause disease in the host, impairing gut function and adversely affecting overall health. The pks gene cluster in the E.
Guojing Zhang, Daqing Sun
doaj   +1 more source

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Various bacteria are suggested to contribute to colorectal cancer (CRC) development1-5, including pks+Escherichia coli, which produces the genotoxin colibactin that induces characteristic mutational signatures in host epithelial cells6.
Blancke, Gillian, Kolata, Magdalena, Shokry, Engy, Jans, Maude, D'Hondt, Aline, Andries, Vanessa, van Loo, Geert, Tejpar, Sabine, Remaut, Han, Vereecke, Lars, Petta, Ioanna, Verbandt, Sara, Ciers, Maarten, Sze, Mozes, Thiran, Alexandra, Vande Voorde, Johan, Berx, Geert, Sumpton, David, Iliev, Iliyan D., Graf, Claudia   +19 more
core   +2 more sources

The Role of clbF in the Pathogenicity of Avian Pathogenic Escherichia coli

Veterinary Sciences
The genotoxin colibactin, a complex secondary metabolite, targets eukaryotic cell cycle machinery and contributes to neonatal sepsis and meningitis.
Meng Wu, Haitao Wu, Ling Li, Pan Hao, Peili Wang   +4 more
doaj   +1 more source

Molecular Genetic and Functional Analysis of pks-Harboring, Extra-Intestinal Pathogenic Escherichia coli From India

Frontiers in Microbiology, 2018
Colibactin, a genotoxin, encoded by the pks pathogenicity island of Escherichia coli belonging to the B2 phylogroup has been reported as a determinant of bacterial pathogenicity. The present study was carried out to detect the pks pathogenicity island in
Arya Suresh, Amit Ranjan, Savita Jadhav, Arif Hussain, Sabiha Shaik, Munirul Alam, Ramani Baddam, Lothar H. Wieler, Niyaz Ahmed, Niyaz Ahmed   +9 more
doaj   +1 more source