Results 91 to 100 of about 5,208 (185)

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage [PDF]

, 2019
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria.
Jennifer Y. H. Lai, McKinnie, Shaun MK, Lai, Jennifer Y.H., Lai, Jennifer YH, Li, Zhong Rui, Moore, Bradley S., Zhang, Wei Peng, Moore, Bradley S, Jie Li, Bradley S. Moore, Qian, Pei-Yuan, Shaun M. K. McKinnie, Zhang, Wenjun, Pei-Yuan Qian, Li, Zhong-Rui, Zhang, Wei-Peng, Zhong-Rui Li, Li, Jie, Qian, Pei Yuan, McKinnie, Shaun M.K., Wenjun Zhang, Wenlong Cai, Wei-Peng Zhang, Cai, Wenlong   +23 more
core   +1 more source

Increased Epithelial Oxygenation Links Colitis to an Expansion of Tumorigenic Bacteria

mBio, 2019
Intestinal inflammation is a risk factor for colorectal cancer formation, but the underlying mechanisms remain unknown. Here, we investigated whether colitis alters the colonic microbiota to enhance its cancer-inducing activity.
Stephanie A. Cevallos, Jee-Yon Lee, Connor R. Tiffany, Austin J. Byndloss, Luana Johnston, Mariana X. Byndloss, Andreas J. Bäumler   +6 more
doaj   +1 more source

Erratum for Wallenstein et al., “ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli”

, 2020
International audienceColibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle ...
Nougayrède, Jean-Philippe, Nadine Rehm, Müller, Rolf, Boyke Bunk, Simone König, Rolf Müller, Wami, Haleluya Tesfaye, Ulrich Dobrindt, Jörg Overmann, Dobrindt, Ulrich, Bossuet-Greif, Nadège, Daniel Sauer, Rudolf von Bünau, Marina Brinkmann, Wallenstein, Alexander, Jean-Philippe Nougayrède, Brinkmann, Marina, Cathrin Spröer, von Bünau, Rudolf, Oswald, Eric, Stefan Homburg, Homburg, Stefan, Bunk, Boyke, Rehm, Nadine, Spröer, Cathrin, Nadège Bossuet-Greif, Haleluya Tesfaye Wami, Selle, Martina, Sauer, Daniel, König, Simone, Alexander Wallenstein, Martina Selle, Overmann, Jörg, Eric Oswald   +33 more
core   +1 more source

Examination of structure, regulation, and function of the non-ribosomal peptide-polyketide colibactin in E. coli

, 2010
Polyketide (PK) und nichtribosomale Peptide (NRP) sind zwei grosse Klassen von Naturstoffen, die eine grosse Vielfalt hinsichtlich ihrer Struktur und Funktion aufweisen. Sie werden von einer Reihe von Bakterien, Pilzen und Pflanzen als Sekundärmetabolite
Krumbholz, Grit
core   +2 more sources

Determining the Sequence of Two Colibactin Genes, clbN and clbB, in Some Clinical Isolates of E. coli

Medical Journal of Babylon
Background: Escherichia coli is a widespread human-infecting bacterium that can produce the genotoxin colibactin, which is encoded by the pks pathogenicity island and has been reported as a determinant of bacterial virulence.
Noor Ismeal Nasser, Mohammed Sabri Abdul-Razzag, Nadia Mudher AL-Hili   +2 more
doaj   +1 more source

Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis

Microorganisms
Colorectal cancer (CRC) stands as a significant global health concern, ranking second in mortality and third in frequency among cancers worldwide. While only a small fraction of CRC cases can be attributed to inherited genetic mutations, the majority ...
Mohammad Sadeghi, Denis Mestivier, Iradj Sobhani   +2 more
doaj   +1 more source

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients

BMC Cancer
Background Colibactin, a genotoxin produced by polyketide synthase harboring (pks + ) bacteria, induces double-strand breaks and chromosome aberrations.
Diantha Terlouw, Arnoud Boot, Quinten R. Ducarmon, Sam Nooij, Manon Suerink, Monique E. van Leerdam, Demi van Egmond, Carli M. Tops, Romy D. Zwittink, Dina Ruano, Alexandra M. J. Langers, Maartje Nielsen, Tom van Wezel, Hans Morreau   +13 more
doaj   +1 more source

Colibactin comes to light [PDF]

Nature Chemical Biology, 2019
openaire   +2 more sources

Expansion resistance against genotoxic E. coli: protective effects of Bifidobacterium pseudolongum in DSS-induced colitis in mice

Frontiers in Microbiology
IntroductionUlcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. Significant alterations to the composition and function of the gut microbiota that favor the expansion of pathobionts have been ...
Ayodeji Samuel Ajayi, Gabriela Fragoso, Annie Calvé, Claire Gerkins, Thibault Maumy, Claire McCartney, Manuela M. Santos, Manuela M. Santos   +7 more
doaj   +1 more source

Macrocyclic colibactins

Nature Chemistry, 2020
openaire   +3 more sources