Results 111 to 120 of about 5,208 (185)

From inflammation to fibrosis and cancer: the emerging role of AIEC-derived metabolites in intestinal disease progression. [PDF]

Exp Mol Med
Ahn JH, Hazelton A, Nguyen J, Arthur JC.
europepmc   +1 more source

Critical intermediates reveal new biosynthetic events in the enigmatic colibactin pathway

, 2016
Colibactin is a potent genotoxin that induces DNA double-strand breaks; it is produced by Escherichia coli strains harboring a pks+ island. It has been ten years since the discovery of this pks+ island (the colibactin biosynthetic gene cluster).
Li, Zhongrui
core  

Apurinic/apyrimidinic endonuclease 1 prevents oxidative DNA damage in intestinal epithelial cells induced by genotoxic Escherichia coli NC101. [PDF]

Redox Biol
Butcher LD, den Hartog G, Ablack AL, Matsubara M, Rovner LM, Rios-Covian D, Thron T, Mazmanian SK, Ablack JNG, Stappenbeck T, Eckmann L, Izumi T, Tirla A, Wernke KM, Herzon SB, Dougherty MW, Jobin C, Kiyono H, Ernst PB, Crowe SE.   +19 more
europepmc   +1 more source

Investigations of the Biosynthesis and Structure of Colibactin, a Cytotoxin Made by Human-Associated Escherichia Coli

, 2016
Humans exist in symbiosis with trillions of bacteria that are collectively referred to as the human microbiota. While commensal microbes are essential for health, some resident microbes can promote disease. Certain strains of human-associated Escherichia
Brotherton, Carolyn A
core  

Gut microbiota-mediated chemotherapy resistance in colorectal cancer: mechanisms and precision interventions. [PDF]

Front Oncol
Li Y, Wang F, Li T, Liu Y.
europepmc   +1 more source

Chemiluminescent Probes Allow for the Rapid Identification of Colibactin-Producing Bacteria. [PDF]

JACS Au
Aguilar Ramos MA, Gutkin S, David M, Shabat D, Balskus EP.   +4 more
europepmc   +1 more source

Microbiome-Genome Crosstalk in Colorectal Cancer: Colibactin Signatures and <i>Fusobacterium nucleatum</i> in Epidemiology, Driver Selection, and Translation. [PDF]

Int J Mol Sci
Jung S.
europepmc   +1 more source

When the carcinogenic window opens before the screening window: the age-threshold blind spot in early-onset colorectal cancer. [PDF]

Front Oncol
Zhang J, Zhou H, Zhang G, Wang HM.
europepmc   +1 more source

Isolation of a highly virulent colibactin-positive tumor-promoting strain of <i>Escherichia coli</i> from the gut microbiota of an adult. [PDF]

mSphere
Weis AM, Matthews OJ, Bell R, Pershing NL, Dankwardt A, Fleming BA, Gigic B, Schneider M, Hardikar S, Toriola AT, Shibata D, Li CI, Byrd DA, Stephens WZ, Ulrich CM, Mulvey MA, Round JL.   +16 more
europepmc   +1 more source

Bacteriophage-mediated restoration of epithelial integrity, DNA damage response, and transcriptomic homeostasis in colon organoids exposed to ETBF and pks + E. coli. [PDF]

Sci Rep
Song MH, Oh EK, Kim IH, Son JS, Yoon SJ, Kim JY, Kim MJ, Jeong SY, Park JW, Ku JL.   +9 more
europepmc   +1 more source