Results 131 to 140 of about 4,211 (161)

The bacterial toxin colibactin triggers prophage induction [PDF]

Nature, 2022
AbstractColibactin is a chemically unstable small-molecule genotoxin that is produced by several different bacteria, including members of the human gut microbiome1,2. Although the biological activity of colibactin has been extensively investigated in mammalian systems3, little is known about its effects on other microorganisms.
Justin E Silpe, Siân V Owen, Michael Baym   +2 more
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Reply to: Macrocyclic colibactins

Nature Chemistry, 2020
Herzon, S. B. Macrocyclic colibactins. Nat. Chem. https://doi.org/10.1038/s41557-020-00551-8 (2020). Li, Z.-R. et al. Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nat. Chem. 11, 880–889 (2019).
Wenjun Zhang, Pei-Yuan Qian
openaire   +2 more sources

Current understandings of colibactin regulation

Microbiology (United Kingdom)
Graphical Abstract
Emily Addington, Sofia Sandalli, Andrew J Roe   +2 more
exaly   +3 more sources

The mysteries of macrocyclic colibactins

Nature Chemistry, 2019
The biosynthetic pathway that produces the structurally uncharacterized gut bacterial genotoxin colibactin can produce unstable, macrocyclic products; however, the extent to which these structures contribute to colibactin’s biological activities is not yet fully understood.
Erik S. Carlson, Emily P. Balskus
openaire   +1 more source

The human gut bacterial genotoxin colibactin alkylates DNA [PDF]

Science, 2019
Bacterial warhead targets DNA The bacterial toxin colibactin causes double-stranded DNA breaks and is associated with the occurrence of bacterially induced colorectal cancer in humans. However, isolation of colibactin is difficult, and its mode of action is poorly understood. Wilson et al.
Matthew R Wilson, Yindi Jiang, Peter W Villalta   +2 more
exaly   +3 more sources

Structure elucidation of colibactin and its DNA cross-links [PDF]

Science, 2019
Double warhead does DNA damage Strains of the human gut bacterium Escherichia coli carrying the clb gene cluster produce a secondary metabolite dubbed colibactin and have been provocatively linked to colorectal cancer in some models ...
Mengzhao Xue, Chung Sub Kim, Alan R Healy   +2 more
exaly   +3 more sources

Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative

Journal of the American Chemical Society, 2021
Colibactin is a polyketide-nonribosomal peptide hybrid secondary metabolite that can form interstrand cross-links in double-stranded DNA. Colibactin-producing Escherichia coli has also been linked to colorectal oncogenesis. Thus, there is a strong interest in understanding the role colibactin may play in oncogenesis.
Tao Zhou, Yuichiro Hirayama, Yuta Tsunematsu, Nanami Suzuki, Seiji Tanaka, Nahoko Uchiyama, Yukihiro Goda, Yuko Yoshikawa, Yuji Iwashita, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Keiji Wakabayashi, Kenji Watanabe   +15 more
openaire   +2 more sources

The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin

EcoSal Plus, 2016
While the DNA damage induced by ionizing radiation and by many chemical compounds and drugs is well characterized, the genotoxic insults inflicted by bacteria are only scarcely documented. However, accumulating evidence indicates that we are exposed to bacterial genotoxins.
Taieb, Frederic, Petit, Claude, Nougayrede, Jean-Philippe, Oswald, Eric   +3 more
openaire   +3 more sources

Closing in on the elusive colibactin toxin

C&EN Global Enterprise, 2019
More than a decade ago, researchers discovered that bacteria in the human gut have been organizing a mutiny. They produce a toxin capable of damaging our DNA. The team, led by Eric Oswald and Jean-Philippe Nougayrede of Inserm, a French medical research institute, reported that strains of Escherichia coli containing a particular gene cluster could ...
openaire   +1 more source

Photoactivated Colibactin Probes Induce Cellular DNA Damage

Angewandte Chemie International Edition, 2018
AbstractColibactin is a small molecule produced by certain bacterial species of the human microbiota that harbour the pks genomic island. Pks+ bacteria induce a genotoxic phenotype in eukaryotic cells and have been linked with colorectal cancer progression.
Lindon W. K. Moodie, Madlen Hubert, Xin Zhou, Michael F. Albers, Richard Lundmark, Sjoerd Wanrooij, Christian Hedberg   +6 more
openaire   +3 more sources