Results 151 to 160 of about 5,208 (185)

Early-Onset Colorectal Cancer in Australia: Environmental, Microbial, and Policy Implications.

Dig Dis
Gosavi R, Bell S, Ooi G, McMurrick PJ, Warrier S, Narasimhan V.   +5 more
europepmc   +1 more source

Co-evolution between colibactin production and resistance is linked to clonal expansions in Escherichia coli

Mäklin T, Calland JK, Mallawaarachchi S, Thorpe HA, Gladstone RA, Corander J.   +5 more
europepmc   +1 more source

Limitation of Colibactin from Klebsiella Pneumonia

openaire   +1 more source

Current understandings of colibactin regulation [PDF]

Microbiology (United Kingdom)
The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA – S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup.
Andrew J Roe, Sofia Sandalli, Emily Addington   +2 more
exaly   +4 more sources

Photoactivated Colibactin Probes Induce Cellular DNA Damage

Angewandte Chemie - International Edition, 2019
Colibactin is a small molecule produced by certain bacterial species of the human microbiota that harbour the pks genomic island. Pks(+) bacteria induce a genotoxic phenotype in eukaryotic cells and have been linked with colorectal cancer progression ...
Sjoerd Wanrooij, Richard Lundmark, Christian Hedberg   +2 more
exaly   +5 more sources

Structure and bioactivity of colibactin

Bioorganic and Medicinal Chemistry Letters, 2020
Colibactin is a secondary metabolite produced by certain strains of bacteria found in the human gut. The presence of colibactin-producing bacteria has been correlated to colorectal cancer in humans. Colibactin was first discovered in 2006, but because it is produced in small quantities and is unstable, it has yet to be isolated from bacterial cultures.
Seth B. Herzon, Kevin M Wernke, Chung Sub Kim   +2 more
exaly   +4 more sources

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Reply to: Macrocyclic colibactins

Nature Chemistry, 2020
Herzon, S. B. Macrocyclic colibactins. Nat. Chem. https://doi.org/10.1038/s41557-020-00551-8 (2020). Li, Z.-R. et al. Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nat. Chem. 11, 880–889 (2019).
Wenjun Zhang, Pei-Yuan Qian
openaire   +2 more sources

Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer [PDF]

Cancer Cell
Co-culture of intestinal organoids with a colibactin-producing pks+ E. coli strain (EcC) revealed mutational signatures also found in colorectal cancer (CRC). E.
Ruben van Boxtel, Charelle Boot, Aurelia Saftien   +2 more
exaly   +4 more sources

In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation

ChemBioChem, 2013
Releasing the cytopath: We have identified an N-myristoyl-D-asparagine (1) as the free N-terminal prodrug scaffold in cytopathogenic Escherichia coli strains expressing the colibactin gene cluster.
Rolf Müller, Youming Zhang, Xiaoying Bian   +2 more
exaly   +2 more sources

The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.

Journal of Infectious Diseases, 2014
International audienceSepsis is a life-threatening infection. Escherichia coli is the first known cause of bacteremia leading to sepsis. Lymphopenia was shown to predict bacteremia better than conventional markers of infection.
Maiwenn Olier, Gabriel Cuevas-Ramos, Eric Oswald   +2 more
exaly   +2 more sources