Results 141 to 150 of about 4,211 (161)

Researchers elucidate colibactin structure

C&EN Global Enterprise, 2019
Some Escherichia coli bacteria in the gut produce a family of metabolites called colibactins, which are associated with increased risk of colon cancer in people.
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A Prodrug Resistance Mechanism Is Involved in Colibactin Biosynthesis and Cytotoxicity

Journal of the American Chemical Society, 2013
Commensal Escherichia coli residing in the human gut produce colibactin, a small-molecule genotoxin of unknown structure that has been implicated in the development of colon cancer. Colibactin biosynthesis is hypothesized to involve a prodrug resistance strategy that entails initiation of biosynthesis via construction of an N-terminal prodrug scaffold ...
Carolyn A, Brotherton, Emily P, Balskus
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Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk

Trends in Microbiology, 2020
Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel diseases (IBD) who have higher levels of colibactin-producing bacteria in their intestines.
Vadim Dubinsky, Iris Dotan, Uri Gophna
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Colibactin: understanding an elusive gut bacterial genotoxin

Natural Product Reports, 2015
This highlight reviews recent studies of colibactin, a structurally uncharacterized genotoxin synthesized by members of the human gut microbiota.
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Microbiota and colorectal cancer: colibactin makes its mark

Nature Reviews Gastroenterology & Hepatology, 2020
Colibactin-producing bacteria are abundant in the gut microbiota of colorectal cancer tumours and promote colon tumorigenesis in mouse models. Now, a new study demonstrates a direct link between exposure of human intestinal epithelial cells to colibactin and two unique mutational fingerprints found in human colorectal tumours.
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Colibactin activates latent viruses

C&EN Global Enterprise, 2022
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Characterization of the Colibactin Biosynthetic Pathway

2019
Chemistry and Chemical ...
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Regulation of the production of colibactin in Escherichia coli

Régulation de la production de colibactine chez Escherichia coli La colibactine est un métabolite secondaire produit principalement par Escherichia coli portant l'îlot génomique de 54 kb pks. Il appartient à la famille des composés chimiques hybrides polykétide/peptide non ribosomique. La colibactine induit des dommages à l'ADN dans les
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The pks island: a bacterial Swiss army knife? Colibactin: beyond DNA damage and cancer

Trends in Microbiology, 2022
Camille V Chagneau, Min Tang-Fichaux, Frédéric Auvray   +2 more
exaly  

Medicinal plant extracts protect epithelial cells from infection and DNA damage caused by colibactin‐producing Escherichia coli , and inhibit the growth of bacteria

Journal of Applied Microbiology, 2021
Yingmanee Tragoolpua, Hisakazu Mihara
exaly