Results 101 to 110 of about 5,208 (185)

Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthetic pathways.

, 2015
Secondary metabolites produced by nonribosomal peptide synthetase (NRPS) or polyketide synthase (PKS) pathways are chemical mediators of microbial interactions in diverse environments.
Vizcaino, M.I., Engel, P., Crawford, J.M.   +2 more
core   +1 more source

Study of colibactin in urinary tract infections

, 2021
Urinary tract infections (UTIs) are among the most common community-acquired or nosocomial bacterial infections. They are most often caused by uropathogenic Escherichia coli (UPECs). We assembled a collection of UPECs from 223 patients suffering from community-acquired UTIs in order to understand the role and impact of potential virulence factors of ...
openaire   +1 more source

Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence

Gut Microbes
Human colorectal cancers (CRCs) are readily colonized by colibactin-producing E. coli (CoPEC). CoPEC induces DNA double-strand breaks, DNA mutations, genomic instability, and cellular senescence.
Guillaume Dalmasso, Antony Cougnoux, Tiphanie Faïs, Virginie Bonnin, Benoit Mottet-Auselo, Hang TT Nguyen, Pierre Sauvanet, Nicolas Barnich, Marine Jary, Denis Pezet, Julien Delmas, Richard Bonnet   +11 more
doaj   +1 more source

Distribution and genetic structure of the Colibactin gene cluster in Enterobacteriaceae

, 2009
Horizontaler Gentransfer zwischen Bakterien – sogar zwischen verschiedenen Spezies – ist ein wichtiger Mechanismus für den Austausch genetischer Information. Dies kann dem Rezipienten einen selektiven Vorteil verleihen, z. B. durch die schnelle Aneignung
Putze, Johannes
core   +1 more source

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer. [PDF]

Nat Genet
Shiba S, Yachida S, Mizutani S, Totoki Y, Nakamura H, Hama N, Miyoshi N, Arai Y, Saito-Adachi M, Kimura H, Hayashi Y, Takamaru H, Tanaka K, Hayashi R, Rokutan H, Ikuta S, Kanemitsu Y, Doki Y, Eguchi H, Hattori S, Saito Y, Yamada T, Shibata T.   +22 more
europepmc   +1 more source

<i>Klebsiella pneumoniae</i> in inflammatory bowel disease and rectal cancer: from gut inflammation to a potential driver of carcinogenesis. [PDF]

Front Microbiol
Xiong S, Yao R.
europepmc   +1 more source

Retraction Note: Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor‑1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses. [PDF]

Gut Pathog
Morgan RN, Saleh SE, Farrag HA, Aboulwafa MM.   +3 more
europepmc   +1 more source

From Symbiont to Potential Carcinogenic Contributor: Examining the Pathogenic Evolution of <i>Morganella morganii</i> in Colorectal Cancer. [PDF]

Infect Drug Resist
Soleymanpour K, Shokouhi B, Kafil HS.
europepmc   +1 more source

A genotoxin associated with colorectal cancer linked to gut dysbiosis in children with cystic fibrosis. [PDF]

J Bacteriol
Barrack KE, Surve SV, de Sousa Bezerra AV, Murphy CE, Soucy SM, Aguilar Ramos MA, Valls RA, Ruff RD, Balskus EP, Sanville JL, Madan JC, O'Toole GA.   +11 more
europepmc   +1 more source

Prevalence and Molecular Characteristics of Klebsiella pneumoniae Harboring the Pks Island from Cancer Patients in China

Infection and Drug Resistance
Qun Wang,1 Xingwei Wang,2 Zhenghua Xie,1 Jiuxin Qu,2 Yongping Lin,1 Jing Hu,3 Liqiang Li,2 Li Zhang1 1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and ...
Wang Q, Wang X, Xie Z, Qu J, Lin Y, Hu J, Li L, Zhang L   +7 more
doaj