Results 61 to 70 of about 4,207 (127)

Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis

Microorganisms
Colorectal cancer (CRC) stands as a significant global health concern, ranking second in mortality and third in frequency among cancers worldwide. While only a small fraction of CRC cases can be attributed to inherited genetic mutations, the majority ...
Mohammad Sadeghi, Denis Mestivier, Iradj Sobhani   +2 more
doaj   +1 more source

Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients

BMC Cancer
Background Colibactin, a genotoxin produced by polyketide synthase harboring (pks + ) bacteria, induces double-strand breaks and chromosome aberrations.
Diantha Terlouw, Arnoud Boot, Quinten R. Ducarmon, Sam Nooij, Manon Suerink, Monique E. van Leerdam, Demi van Egmond, Carli M. Tops, Romy D. Zwittink, Dina Ruano, Alexandra M. J. Langers, Maartje Nielsen, Tom van Wezel, Hans Morreau   +13 more
doaj   +1 more source

Colibactin-producing Escherichia coli enhance resistance to chemotherapeutic drugs by promoting epithelial to mesenchymal transition and cancer stem cell emergence

Gut Microbes
Human colorectal cancers (CRCs) are readily colonized by colibactin-producing E. coli (CoPEC). CoPEC induces DNA double-strand breaks, DNA mutations, genomic instability, and cellular senescence.
Guillaume Dalmasso, Antony Cougnoux, Tiphanie Faïs, Virginie Bonnin, Benoit Mottet-Auselo, Hang TT Nguyen, Pierre Sauvanet, Nicolas Barnich, Marine Jary, Denis Pezet, Julien Delmas, Richard Bonnet   +11 more
doaj   +1 more source

Campylobacter jejuni infection impacts host-derived miRNAs targeting bacterial and host genes

Microbiology Spectrum
The intestinal microbiota has been shown to influence host-derived microRNAs (miRNAs), small regulatory RNAs involved in host-pathogen interactions. However, the specific role of individual bacterial species in modulating host extracellular vesicles (EV)-
Siddhi Chitre, Raad Z. Gharaibeh, Rachel C. Newsome, Jinmai Jiang, Andrew Brock, Thomas D. Schmittgen, Christian Jobin   +6 more
doaj   +1 more source

Expansion resistance against genotoxic E. coli: protective effects of Bifidobacterium pseudolongum in DSS-induced colitis in mice

Frontiers in Microbiology
IntroductionUlcerative colitis is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. Significant alterations to the composition and function of the gut microbiota that favor the expansion of pathobionts have been ...
Ayodeji Samuel Ajayi, Gabriela Fragoso, Annie Calvé, Claire Gerkins, Thibault Maumy, Claire McCartney, Manuela M. Santos, Manuela M. Santos   +7 more
doaj   +1 more source

Towards a safer probiotic: clbD deletion attenuates EcN-induced DNA damage responses and epithelial inflammatory transcriptional responses

Frontiers in Cellular and Infection Microbiology
Escherichia coli Nissle 1917 (EcN) is widely used as a probiotic and engineering chassis, but its carriage of the pks genomic island raises safety concerns related to the genotoxin colibactin.
Wei-Ming Chen, Wei-Ming Chen, Wei-Ming Chen, Ming-Yang Sun, Ming-Yang Sun, Ming-Yang Sun, Ji-Yuan Ye, Ji-Yuan Ye, Ji-Yuan Ye, De-Cheng Tan, De-Cheng Tan, De-Cheng Tan, Zi-Yi Zhang, Zi-Yi Zhang, Zi-Yi Zhang, Jing-Jing Liu, Jing-Jing Liu   +16 more
doaj   +1 more source

From inflammation to fibrosis and cancer: the emerging role of AIEC-derived metabolites in intestinal disease progression. [PDF]

Exp Mol Med
Ahn JH, Hazelton A, Nguyen J, Arthur JC.
europepmc   +1 more source

Chemiluminescent Probes Allow for the Rapid Identification of Colibactin-Producing Bacteria. [PDF]

JACS Au
Aguilar Ramos MA, Gutkin S, David M, Shabat D, Balskus EP.   +4 more
europepmc   +1 more source

Microbiome-Genome Crosstalk in Colorectal Cancer: Colibactin Signatures and <i>Fusobacterium nucleatum</i> in Epidemiology, Driver Selection, and Translation. [PDF]

Int J Mol Sci
Jung S.
europepmc   +1 more source

Isolation of a highly virulent colibactin-positive tumor-promoting strain of <i>Escherichia coli</i> from the gut microbiota of an adult. [PDF]

mSphere
Weis AM, Matthews OJ, Bell R, Pershing NL, Dankwardt A, Fleming BA, Gigic B, Schneider M, Hardikar S, Toriola AT, Shibata D, Li CI, Byrd DA, Stephens WZ, Ulrich CM, Mulvey MA, Round JL.   +16 more
europepmc   +1 more source