Results 61 to 70 of about 5,208 (185)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Structure elucidation of colibactin and its DNA cross-links [PDF]

Science, 2019
Double warhead does DNA damage Strains of the human gut bacterium Escherichia coli carrying the clb gene cluster produce a secondary metabolite dubbed colibactin and have been provocatively linked to colorectal cancer in some models ...
Mengzhao Xue, Chung Sub Kim, Alan R. Healy, Kevin M. Wernke, Zhixun Wang, Madeline C. Frischling, Emilee E. Shine, Weiwei Wang, Seth B. Herzon, Jason M. Crawford   +9 more
openaire   +2 more sources

Synthetic studies of colibactin, a carcinogenic gut microbiome metabolite [PDF]

, 2022
The human microbiota is now understood to be intimately linked to host physiology. Recent studies indicate that microbiota species which possess a biosynthetic gene cluster – termed clb – contribute to the development and progression of colorectal ...
Wernke, Kevin Mark
core   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source

Colibactin DNA damage signature indicates causative role in colorectal cancer

, 2019
Colibactin, a potent genotoxin of Escherichia coli , causes DNA double strand breaks (DSBs) in human cells. We investigated if colibactin creates a particular DNA damage signature in infected cells by identifying DSBs in colon cells after infection with ...
Iftekhar, A, Katainen, R, Crosetto, N, Orozco, M, Aaltonen, LA, Dziubańska-Kusibab, PJ, Meyer, TF, Berger, H, Bouwman, BAM, Battistini, F   +9 more
core   +1 more source

Incidence Trends of Early‐Onset Colorectal Cancer in Germany: A Registry‐Based Study From 2003 to 2023

International Journal of Cancer, Volume 159, Issue 9, Page 2207-2218, 1 November 2026.
The evidence on the rising incidence of colorectal cancer among adults below 50 years of age largely stems from the United States. Using high‐quality cancer registry data for the 2003–2023 period in Germany, this study found a moderate increase of early‐onset colorectal cancer incidence that was limited to those aged 20–39 years and more pronounced ...
Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller‐Nordhorn, the ALSTER Working Group, Josephine Kanbach, Sabine Luttmann, Meike Ressing, Cécile Ronckers, Soo‐Zin Kim‐Wanner, Alice Nennecke, Frederik Peters, Klaus Kraywinkel, Roxana Müller‐Eberstein, Hannah Baltus, Paula Grieger, Antje Schliemann, Annika Waldmann   +20 more
wiley   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, Volume 159, Issue 8, Page 1928-1936, 15 October 2026.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Genetic and Functional Analysis of the pks Gene in Clinical Klebsiella pneumoniae Isolates

Microbiology Spectrum, 2023
The pks gene cluster encodes colibactin, which can cause DNA damage and enhance the virulence in Escherichia coli. However, the role of the pks gene in Klebsiella pneumoniae has not been fully discussed.
Chenshuo Luo, Yanshu Chen, Xueni Hu, Shanjian Chen, Yulan Lin, Xiaoqian Liu, Bin Yang   +6 more
doaj   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa

Gut Microbes
Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+ Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus structure increases the vulnerability of host mucosa to colibactin-induced DNA ...
Amanda Mandarino Alves, Chiara Lecchi, Sharon Lopez, Alessia Stornetta, Prince P. Mathai, Peter W. Villalta, Satoshi Ishii, Emily P. Balskus, Silvia Balbo, Alexander Khoruts   +9 more
doaj   +1 more source