Results 61 to 70 of about 4,211 (161)

Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor-1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses

Gut Pathogens, 2019
Background The colibactin and cytotoxic necrotizing factor 1 (Cnf 1) are toxins with cell cycle modulating effects that contribute to tumorgenesis and hyperproliferation.
Radwa N. Morgan, Sarra E. Saleh, Hala A. Farrag, Mohammad M. Aboulwafa   +3 more
doaj   +1 more source

The Role of Neonatal Ward Environment as a Reservoir for the Dissemination of Multidrug‐Resistant Klebsiella pneumoniae in Algeria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Whole‐genome sequencing of multidrug‐resistant Klebsiella pneumoniae from a neonatal ward environment in Chlef revealed persistent resistance genes and the clonal spread of high‐risk ST13. These findings highlight the hospital environment as a potential reservoir for transmission of resistant K. pneumoniae.
Meriem Derkaoui, Martin Alexander Fischer, Mohammed Sebaihia, Rachida Namoune, Fatiha Bouheudjeur, Meryem Beloukarif, Bakhta Madaoui, Bruno Silvester Lopes   +7 more
wiley   +1 more source

Genomic Map of Escherichia coli and Single Nucleotide Polymorphism Markers in Colorectal Cancer

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
This study identified colorectal cancer‐associated SNPs in Escherichia coli using PacBio full‐genome sequencing, establishing a highly accurate SNP‐based model for non‐invasive colorectal cancer risk prediction. ABSTRACT Gut microbial single nucleotide polymorphisms (SNPs) offer stable, specific genetic markers for disease diagnosis.
Yang Xi, Zhong Liping, Xu Yating, Xu Yang, Chu Jian, Chu Caiyun, Li Shuwen, Zhang Zian, Yu Xiaojian, Han Shuwen, Wu Wei   +10 more
wiley   +1 more source

Exploring the Antimicrobial Efficacy of Mesenchymal Stem Cell Secretome Against Klebsiella pneumoniae in Urinary Tract Infections

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Antimicrobial resistance (AMR) has become a global health crisis, with Klebsiella pneumoniae (K. pneumoniae) emerging as a major driver of AMR and a leading cause of urinary tract infections (UTIs). Mesenchymal stem cell (MSC)‐derived secretomes have gained attention for their antimicrobial properties.
Leen Ali, Elie Salem Sokhn, Charbel Khalil, Fatima A. Saleh   +3 more
wiley   +1 more source

Gut Microbiota: A Potential Role in Modulating Carcinogenesis and Response to Anti‐Cancer Therapies

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background The effects of microbiota on cancer are not only limited to their role in oncogenesis, progression and response to anticancer therapies; the disease itself is also influenced by microbiota. In recent investigations, alterations in the gut bacterial community between cancer patients and healthy individuals have been reported ...
Awgichew Shewasinad Yehualashet, Eleni Teklu Fersha, Berhan Begashaw Yikna, Kassahun Dires Ayenew   +3 more
wiley   +1 more source

Probiotics Cancer Interaction, Prevention, and Therapy

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Cancer is a significant global health concern and ranks as the second most common cause of death on a worldwide scale. A combination of hereditary and lifestyle variables, such as diet, smoking, alcohol consumption, physical exercise, and the gut microbiota, impacts cancer development. Dysbiosis, an imbalance in gut microorganisms, can promote
Mostafa Saebi, Amir Hossein Barjasteh, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Setayesh Ramazanpour, Negar Ebadpour, Afsane Fadaee, Seyed‐Alireza Esmaeili   +7 more
wiley   +1 more source

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

MedComm, Volume 7, Issue 5, May 2026.
Tumors are no longer viewed as sterile but dynamic ecosystems harboring low‐biomass intratumoral microbiota. These microbes, derived from gut, oral cavity, or circulation, shape tumorigenesis and therapy response via core mechanisms: immunomodulation (regulating T cells, macrophages), metabolic reprogramming (SCFAs, indoles, bile acids), chronic ...
Haoling Zhang, Zengkan Du, Ping Lu, Aimin Jiang, Yadong Guo, Yawei Liu, Zhijing Song, Bing Dai, Wangzheqi Zhang   +8 more
wiley   +1 more source

Colibactin Causes Colorectal Cancer–Associated Mutational Signature [PDF]

Cancer Discovery, 2020
Abstract The pks+ E. coli metabolite colibactin caused a unique mutational signature in intestinal organoids.
openaire   +2 more sources

The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer

Frontiers in Microbiology
Escherichia coli is part of the normal flora of the human gut and performs vital functions; however, certain strains can cause disease in the host, impairing gut function and adversely affecting overall health. The pks gene cluster in the E.
Guojing Zhang, Daqing Sun
doaj   +1 more source

Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil

Microbiology and Immunology, Volume 70, Issue 5, Page 261-267, May 2026.
ABSTRACT Hypervirulent Klebsiella pneumoniae (hvKp) has emerged globally as a major public health concern, often associated with severe community‐acquired and healthcare‐associated human infections. Despite alerts from PAHO/WHO on convergent hvKp strains with multidrug resistance in Latin America, comprehensive data from Brazil, the region's largest ...
Carlos Henrique Camargo, Ana Beatriz Nascimento Costa, Amanda Yaeko Yamada, Daniel de Sena Miranda, Pedro Smith Pereira Ferraro, Andreia Rodrigues de Souza, Amanda Maria de Jesus Bertani, Karoline Rodrigues Campos, Marlon Benedito Nascimento Santos, Rafaela Mastrangelo Rissetti, Carolina Lechinski de Paula, Patrik Júnior de Lima Paz, Maria Solange Duarte Soares, Christiane Salvador, Giovanna de Pinho Pieri, Jorge Siguemassa Higa, Daniela dos Santos Souza, Márcio Garcia Ribeiro, Claudio Tavares Sacchi, Monique Ribeiro Tiba‐Casas, Geraldine Madalosso, Denise Brandao de Assis   +21 more
wiley   +1 more source