Results 31 to 40 of about 4,211 (161)
Depurination of colibactin-derived interstrand cross-links [PDF]
Biochemistry, 2019 Abstract Colibactin is a genotoxic gut microbiome metabolite long suspected of playing an etiological role in colorectal cancer progression. Evidence suggests colibactin forms DNA interstrand cross-links (ICLs) in eukaryotic cells and activates ICL repair pathways, leading to the production of ICL-dependent DNA double-strand breaks ...
Mengzhao Xue +2 more
openaire +2 more sources
The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota
mBio, 2017 An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development of colorectal cancers.
Delphine Payros +9 more
doaj +1 more source
mSphere, 2021 Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal ...
Jean-Philippe Nougayrède +9 more
doaj +1 more source
Uropathogenic E. coli induces DNA damage in the bladder.
PLoS Pathogens, 2021 Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the cleavage product ...
Camille V Chagneau +14 more
doaj +1 more source
Escherichia coli ClbS is a colibactin resistance protein [PDF]
Molecular Microbiology, 2015 SummaryThe genomic pks island codes for the biosynthetic machinery that produces colibactin, a peptide‐polyketide metabolite. Colibactin is a genotoxin that contributes to the virulence of extra‐intestinal pathogenic Escherichia coli and promotes colorectal cancer.
Bossuet-Greif, Nadège +7 more
openaire +4 more sources
Bio-Protocol, 2018 The genotoxin colibactin is produced by several species of Enterobacteriaceae. This genotoxin induces DNA damage, cell cycle arrest, senescence and death in eukaryotic cells (Nougayrède et al., 2006; Taieb et al., 2016).
Sophie Tronnet, Eric Oswald
doaj +1 more source
ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance [PDF]
Journal of the American Chemical Society, 2017 Certain commensal Escherichia coli contain the clb biosynthetic gene cluster that codes for small molecule prodrugs known as precolibactins. Precolibactins are converted to colibactins by N-deacylation; the latter are postulated to be genotoxic and to contribute to colorectal cancer formation.
Prabhanshu Tripathi +6 more
openaire +2 more sources
Bio-Protocol, 2017 Strains of Escherichia coli bearing the pks genomic island synthesize the genotoxin colibactin. Exposure of eukaryotic cells to E. coli producing colibactin induces DNA damages, ultimately leading to cell cycle arrest, senescence and death.
Nadège Bossuet-Greif +4 more
doaj +1 more source
MATE transport of the E. coli-derived genotoxin colibactin [PDF]
Nature Microbiology, 2016 Various forms of cancer have been linked to the carcinogenic activities of microorganisms(1-3). The virulent gene island polyketide synthase (pks) produces the secondary metabolite colibactin, a genotoxic molecule(s) causing double-stranded DNA breaks(4) and enhanced colorectal cancer development(5,6).
Mousa, Jarrod J. +8 more
openaire +3 more sources
mSphereColibactin is a genotoxic secondary metabolite produced by certain Enterobacteriaceae strains that populate the intestine and produces a specific mutational signature in human colonocytes. However, the host pathways involved in colibactin response remain
Michael W. Dougherty +7 more
doaj +1 more source