Results 31 to 40 of about 5,208 (185)

Structural basis of colibactin activation by the ClbP peptidase

Nature Chemical Biology, 2022
AbstractColibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after export to the periplasm.
José A. Velilla, Matthew R. Volpe, Grace E. Kenney, Richard M. Walsh, Emily P. Balskus, Rachelle Gaudet   +5 more
openaire   +4 more sources

Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains

BMC Cancer, 2021
Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island.
Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt, Manuela M. Santos   +6 more
doaj   +1 more source

Phosphopantetheinyl transferase ClbA contributes to the virulence of avian pathogenic Escherichia coli in meningitis infection of mice.

PLoS ONE, 2022
Avian pathogenic Escherichia coli (APEC), which has potential zoonotic risk, can cause severe systemic infections such as septicemia and meningitis in poultry.
Xia Meng, Yanfei Chen, Peili Wang, Pengpeng Xia, Jinqiu Wang, Mengping He, Chunhong Zhu, Heng Wang, Guoqiang Zhu   +8 more
doaj   +1 more source

Characterization of the Colibactin Biosynthetic Pathway

, 2019
Colibactin is a genotoxin produced by human gut Escherichia coli strains. This metabolite is biosynthesized by the non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymes encoded in a 54-kilobase biosynthetic gene cluster (the pks ...
Zha, Li
core   +2 more sources

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

mSphere, 2020
Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for
Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu   +5 more
doaj   +1 more source

Correlation Between Antimicrobial Resistance, Virulence Determinants and Biofilm Formation Ability Among Extraintestinal Pathogenic Escherichia coli Strains Isolated in Catalonia, Spain

Frontiers in Microbiology, 2022
Escherichia coli is a well-characterized bacterium highly prevalent in the human intestinal tract and the cause of many important infections. The aim of this study was to characterize 376 extraintestinal pathogenic E.
Victoria Ballén, Yaiza Gabasa, Carlos Ratia, Melany Sánchez, Sara Soto   +4 more
doaj   +1 more source

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer [PDF]

, 2020
The mucosal epithelium is a common target of damage by chronic bacterial infections and the accompanying toxins, and most cancers originate from this tissue.
Dziubanska-Kusibab, Paulina J., Bouwman, Britta A. M., Orozco, Modesto, Iftekhar, A., Berger, Hilmar, Crosetto, N., Aaltonen, L., Aaltonen, Lauri A., Katainen, R., Battistini, F., Meyer, T., Cajuso, Tatiana, Orozco, M., Crosetto, Nicola, Berger, H., Katainen, Riku, Dziubanska-Kusibab, P., Cajuso, T., Iftekhar, Amina, Bouwman, B., Battistini, Federica, Meyer, Thomas F.   +21 more
core   +1 more source

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.

PLoS Pathogens, 2022
Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing.
Jun Jie Wong, Foo Kiong Ho, Pei Yi Choo, Kelvin K L Chong, Chee Meng Benjamin Ho, Ramesh Neelakandan, Damien Keogh, Timothy Barkham, John Chen, Chuan Fa Liu, Kimberly A Kline   +10 more
doaj   +1 more source

Structure elucidation of colibactin [PDF]

, 2019
Abstract Colibactin is a gut microbiome metabolite of unknown structure that has been implicated in colorectal cancer formation. Several studies now suggest that the tumorgenicity of colibactin derives from interstrand cross-linking of host DNA.
Xue, Mengzhao, Kim, Chung Sub, Healy, Alan R., Wernke, Kevin M., Wang, Zhixun, Frischling, Madeline C., Shine, Emilee E., Wang, Weiwei, Herzon, Seth B., Crawford, Jason M.   +9 more
openaire   +1 more source

The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota

mBio, 2017
An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development of colorectal cancers.
Delphine Payros, Ulrich Dobrindt, Patricia Martin, Thomas Secher, Ana Paula F. L. Bracarense, Michèle Boury, Joelle Laffitte, Philippe Pinton, Eric Oswald, Isabelle P. Oswald   +9 more
doaj   +1 more source