Results 11 to 20 of about 4,211 (161)
The Genotoxin Colibactin Shapes Gut Microbiota in Mice [PDF]
mSphere, 2020 The genotoxin colibactin produced by resident bacteria of the gut microbiota may have tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of colibactin on gut microbiota composition and functions remains unknown.
Sophie Tronnet +6 more
doaj +6 more sources
Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria [PDF]
BMC Microbiology, 2021 Background The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E.
Yuta Tsunematsu +15 more
doaj +3 more sources
D-Serine reduces the expression of the cytopathic genotoxin colibactin
Microbial Cell, 2023 Some Escherichia coli strains harbour the pks island, a 54 kb genomic island en-coding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chro-mosomal instability.
Jennifer C. Hallam +7 more
doaj +4 more sources
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
mSphere, 2019 Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells.
Camille V. Chagneau +8 more
doaj +7 more sources
Colibactin-induced damage in bacteria is cell contact independent
mBioThe bacterial toxin colibactin, produced primarily by the B2 phylogroup of Escherichia coli, underlies some cases of colorectal cancers. Colibactin crosslinks DNA and induces genotoxic damage in both mammalian and bacterial cells.
Emily Lowry, Amir Mitchell
doaj +4 more sources
Synthesis and Biological Evaluation of Colibactin Derivatives. [PDF]
ACS Chem BiolColibactin is a pseudo-C2-symmetric gut microbiome metabolite that induces DNA interstrand cross-links and plays a causal role in colorectal cancer. Since efforts to isolate colibactin have not been successful, we developed colibactin 742 (3a/b) as a stable colibactin mimetic. However, colibactin 742 (3a/b) exists as a mixture of ring and chain isomers,
Airan Y +7 more
europepmc +3 more sources
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in
mSphere, 2020 Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression in eukaryotes.
Alexander Wallenstein +16 more
doaj +3 more sources
The colibactin warhead crosslinks DNA [PDF]
Nature Chemistry, 2015 Members of the human microbiota are increasingly being correlated to human health and disease states, but the majority of the underlying microbial metabolites that regulate host-microbe interactions remain largely unexplored. Select strains of Escherichia coli present in the human colon have been linked to the initiation of inflammation-induced ...
Vizcaino, Maria I., Crawford, Jason M.
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Biosynthesis and bioactivities of microbial genotoxin colibactins
Natural Product Reports, 2022 This review provides an update on biosynthesis and bioactivities of colibactin(s), the long-sought genotoxins produced by the pks island of Escherichia coli.
Jian-Wei Tang +4 more
openaire +3 more sources
A Mechanistic Model for Colibactin-Induced Genotoxicity [PDF]
Journal of the American Chemical Society, 2016 Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. clb+ E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917 ...
Alan R, Healy +4 more
openaire +2 more sources