Results 11 to 20 of about 4,207 (127)

ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli

mSphere, 2020
Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression in eukaryotes.
Alexander Wallenstein, Nadine Rehm, Marina Brinkmann, Martina Selle, Nadège Bossuet-Greif, Daniel Sauer, Boyke Bunk, Cathrin Spröer, Haleluya Tesfaye Wami, Stefan Homburg, Rudolf von Bünau, Simone König, Jean-Philippe Nougayrède, Jörg Overmann, Eric Oswald, Rolf Müller, Ulrich Dobrindt   +16 more
doaj   +3 more sources

Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria

BMC Microbiology, 2021
Background The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E.
Yuta Tsunematsu, Koji Hosomi, Jun Kunisawa, Michio Sato, Noriko Shibuya, Emiko Saito, Haruka Murakami, Yuko Yoshikawa, Yuji Iwashita, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Motohiko Miyachi, Keiji Wakabayashi, Kenji Watanabe   +15 more
doaj   +1 more source

D-Serine reduces the expression of the cytopathic genotoxin colibactin

Microbial Cell, 2023
Some Escherichia coli strains harbour the pks island, a 54 kb genomic island en-coding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chro-mosomal instability.
Jennifer C. Hallam, Sofia Sandalli, Iris Floria, Natasha C. A. Turner, Min Tang-Fichaux, Eric Oswald, Nicky O’Boyle, Andrew J. Roe   +7 more
doaj   +1 more source

The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction

Frontiers in Pharmacology, 2022
The human microbiota produces molecules that are evolved to interact with the diverse cellular machinery of both the host and microbes, mediating health and diseases.
Walaa K. Mousa, Walaa K. Mousa
doaj   +1 more source

Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli

mBio, 2022
Bacteria have to process several levels of gene regulation and coordination of interconnected regulatory networks to ensure the most adequate cellular response to specific growth conditions.
Nadine Rehm, Alexander Wallenstein, Marla Keizers, Stefan Homburg, Giuseppe Magistro, Camille V. Chagneau, Hanna Klimek, Olga Revelles, Emmanuelle Helloin, Johannes Putze, Jean-Philippe Nougayrède, Sören Schubert, Eric Oswald, Ulrich Dobrindt   +13 more
doaj   +1 more source

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

mSphere, 2020
Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for
Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu   +5 more
doaj   +1 more source

Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains

BMC Cancer, 2021
Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island.
Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt, Manuela M. Santos   +6 more
doaj   +1 more source

Phosphopantetheinyl transferase ClbA contributes to the virulence of avian pathogenic Escherichia coli in meningitis infection of mice.

PLoS ONE, 2022
Avian pathogenic Escherichia coli (APEC), which has potential zoonotic risk, can cause severe systemic infections such as septicemia and meningitis in poultry.
Xia Meng, Yanfei Chen, Peili Wang, Pengpeng Xia, Jinqiu Wang, Mengping He, Chunhong Zhu, Heng Wang, Guoqiang Zhu   +8 more
doaj   +1 more source

Correlation Between Antimicrobial Resistance, Virulence Determinants and Biofilm Formation Ability Among Extraintestinal Pathogenic Escherichia coli Strains Isolated in Catalonia, Spain

Frontiers in Microbiology, 2022
Escherichia coli is a well-characterized bacterium highly prevalent in the human intestinal tract and the cause of many important infections. The aim of this study was to characterize 376 extraintestinal pathogenic E.
Victoria Ballén, Yaiza Gabasa, Carlos Ratia, Melany Sánchez, Sara Soto   +4 more
doaj   +1 more source

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition.

PLoS Pathogens, 2022
Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing.
Jun Jie Wong, Foo Kiong Ho, Pei Yi Choo, Kelvin K L Chong, Chee Meng Benjamin Ho, Ramesh Neelakandan, Damien Keogh, Timothy Barkham, John Chen, Chuan Fa Liu, Kimberly A Kline   +10 more
doaj   +1 more source