Results 11 to 20 of about 5,208 (185)
Oxygen concentration modulates colibactin production
Gut Microbes, 2023 Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite.
Nadège Bossuet +8 more
doaj +6 more sources
D-Serine reduces the expression of the cytopathic genotoxin colibactin
Microbial Cell, 2023 Some Escherichia coli strains harbour the pks island, a 54 kb genomic island en-coding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chro-mosomal instability.
Jennifer C. Hallam +7 more
doaj +5 more sources
The Genotoxin Colibactin Shapes Gut Microbiota in Mice [PDF]
mSphere, 2020 The genotoxin colibactin produced by resident bacteria of the gut microbiota may have tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of colibactin on gut microbiota composition and functions remains unknown.
Sophie Tronnet +6 more
doaj +7 more sources
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
mSphere, 2019 Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells.
Camille V. Chagneau +8 more
doaj +8 more sources
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in
mSphere, 2020 Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression in eukaryotes.
Alexander Wallenstein +16 more
doaj +4 more sources
The bacterial toxin colibactin triggers prophage induction [PDF]
Nature, 2023 Colibactin is a chemically unstable small molecule genotoxin produced by multiple different bacteria, including members of the human gut microbiome.
Wong, Joel W. H. +4 more
core +5 more sources
Escherichia coliClbS is a colibactin resistance protein [PDF]
Molecular Microbiology, 2016 International audienceThe genomic pks island codes for the biosynthetic machinery that produces colibactin, a peptide-polyketide metabolite. Colibactin is a genotoxin that contributes to the virulence of extra-intestinal pathogenic Escherichia coli and ...
Bonnet, Richard +7 more
core +5 more sources
The human gut bacterial genotoxin colibactin alkylates DNA [PDF]
Science, 2020 Certain Escherichia coli strains residing in the human gut produce colibactin, a small-molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects ...
Ngo, Lizzie +2 more
core +3 more sources
Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria [PDF]
BMC Microbiology, 2021 Background The Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E.
Yuta Tsunematsu +15 more
doaj +3 more sources
mSphereColibactin is a genotoxic secondary metabolite produced by certain Enterobacteriaceae strains that populate the intestine and produces a specific mutational signature in human colonocytes. However, the host pathways involved in colibactin response remain
Michael W. Dougherty +7 more
doaj +2 more sources