Results 41 to 50 of about 3,614 (202)
Frontiers in Microbiology, 2017 Lactic acid bacteria and yeasts, representing the prevailing microbiota associated with different foods generally consumed without any cooking, were identified and characterized in vitro for some functional properties, such as acid-bile tolerance and ...
Roberta Prete +5 more
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Overexpression of Mdb1 alters genotoxin sensitivity.
, 2014 Overexpression of wild-type but not phospho-binding mutants of Mdb1 results in genotoxin sensitivity in wild type and set9Δ, but not htaAQ strain background. Cells were pregrown in a thiamine-free medium for 20 h before being spotted on YES-based plates.
Hai-Tao Wang (561009) +4 more
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Mechanisms of assembly and cellular interactions for the bacterial genotoxin CDT. [PDF]
PLoS Pathogens, 2005 Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (CdtB)
Dragana Nesic, C Erec Stebbins
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مجلة بغداد للعلوم, 2020 The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand ...
Mohammed T. Hussein +4 more
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The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Neoplasia: An International Journal for Oncology Research, 2023 Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E.
Michael W. Dougherty +11 more
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Caspase Regulation of Genotoxin-Induced Neural Precursor Cell Death
, 2003 Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain.
Lindsten, T +9 more
core +1 more source
, 2023 International audienceThe genotoxin colibactin produced by Escherichia coli is involved in the development of colorectal cancers. This secondary metabolite is synthesized by a multi-protein machinery, mainly composed of non-ribosomal peptide synthetase ...
Pauline Macheboeuf +7 more
core +1 more source
Genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits Wnt signaling. [PDF]
PLoS ONE, 2012 Various types of somatic stem cell have been tested for their response to genotoxic exposure, since these cells are likely to be important to regeneration, aging and cancer.
Kristine S Klos +2 more
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Transplacental transfer of genotoxins and transplacental carcinogenesis. [PDF]
Environmental Health Perspectives, 1993 A number of chemical compounds induce cancer in the offspring of animals treated with these compounds. The fetus is sensitive to the toxic and teratogenic effects of chemicals in the early embryonic stages, whereas it is sensitive to carcinogenic effects during late fetal stages.
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Toxicon, 2016 Escherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants are stably colonized by E. coli within a few days after birth. Certain E.
openaire +3 more sources