Results 41 to 50 of about 2,972 (172)
Toxicon, 2016 Escherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants are stably colonized by E. coli within a few days after birth. Certain E.
openaire +3 more sources
International Journal of Cancer, EarlyView.Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai +3 more
wiley +1 more source
Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?
Biomolecules, 2015 The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-homologous small GTPases. It is well characterized as a membrane-bound signal transducing molecule that is involved in the regulation of cell motility and adhesion as well
Gerhard Fritz, Christian Henninger
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Journal of Clinical Laboratory Analysis, EarlyView.Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley +1 more source
Genotoxins and the initiation of sporadic breast cancer [PDF]
Mutagenesis, 2001 Breast cancer is the most frequently diagnosed female malignancy world-wide. The aetiology of the majority of cases remains obscure and the only genotoxin as yet known to initiate breast cancer is ionizing radiation. High penetrance susceptibility genes probably account for no more than 5-10% of cases.
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From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
Frontiers in Immunology, 2021 Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis.
Yi-Ru Lai +16 more
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Dasatinib and quercetin prevent alveolar bone loss in aged mice
Journal of Periodontology, EarlyView.Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli +7 more
wiley +1 more source
Cytolethal distending toxin enhances Escherichia coli urinary tract infection
Infection and ImmunityCytolethal distending toxin (CDT) is a virulence factor produced by several gram-negative bacteria, including Escherichia coli, the most prevalent etiological agent of urinary tract infections (UTIs). CDT causes DNA damage to eukaryotic cells, leading to
Santosh Paudel +5 more
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Aging and periodontitis increase brain dissemination of oral bacteria
Journal of Periodontology, EarlyView.Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu +7 more
wiley +1 more source
Bio-Protocol, 2017 Strains of Escherichia coli bearing the pks genomic island synthesize the genotoxin colibactin. Exposure of eukaryotic cells to E. coli producing colibactin induces DNA damages, ultimately leading to cell cycle arrest, senescence and death.
Nadège Bossuet-Greif +4 more
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