Results 31 to 40 of about 2,972 (172)
Detection of DNA damage by alkaline comet assay in mouse colonic mucosa
STAR Protocols, 2021 Summary: We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin.
Elisa Boutet-Robinet +4 more
doaj +1 more source
Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells. [PDF]
PLoS ONE, 2013 Cellular senescence is an irreversible state of proliferation arrest evoked by a myriad of stresses including oncogene activation, telomere shortening/dysfunction and genotoxic insults. It has been associated with tumor activation, immune suppression and
Thomas Secher +3 more
doaj +1 more source
STAR Protocols, 2021 Summary: We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin.
María López Chiloeches +3 more
doaj +1 more source
Mechanisms of assembly and cellular interactions for the bacterial genotoxin CDT. [PDF]
PLoS Pathogens, 2005 Many bacterial pathogens that cause different illnesses employ the cytolethal distending toxin (CDT) to induce host cell DNA damage, leading to cell cycle arrest or apoptosis. CDT is a tripartite holotoxin that consists of a DNase I family nuclease (CdtB)
Dragana Nesic, C Erec Stebbins
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2012 The cytolethal distending toxins (CDTs) comprise a family of intracellular-acting bacterial protein toxins whose actions upon eukaryotic cells result in several consequences, the most characteristic of which is the induction of G2/M cell cycle arrest ...
Amandeep eGargi +2 more
doaj +1 more source
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Neoplasia: An International Journal for Oncology Research, 2023 Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E.
Michael W. Dougherty +11 more
doaj +1 more source
Frontiers in Microbiology, 2017 Lactic acid bacteria and yeasts, representing the prevailing microbiota associated with different foods generally consumed without any cooking, were identified and characterized in vitro for some functional properties, such as acid-bile tolerance and ...
Roberta Prete +5 more
doaj +1 more source
مجلة بغداد للعلوم, 2020 The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand ...
Mohammed T. Hussein +4 more
doaj +1 more source
Transplacental transfer of genotoxins and transplacental carcinogenesis. [PDF]
Environmental Health Perspectives, 1993 A number of chemical compounds induce cancer in the offspring of animals treated with these compounds. The fetus is sensitive to the toxic and teratogenic effects of chemicals in the early embryonic stages, whereas it is sensitive to carcinogenic effects during late fetal stages.
openaire +3 more sources
Genotoxic exposure during juvenile growth of mammary gland depletes stem cell activity and inhibits Wnt signaling. [PDF]
PLoS ONE, 2012 Various types of somatic stem cell have been tested for their response to genotoxic exposure, since these cells are likely to be important to regeneration, aging and cancer.
Kristine S Klos +2 more
doaj +1 more source