Results 31 to 40 of about 3,614 (202)
Environmental effects of genotoxins (eco-genotoxicology) [PDF]
Mutagenesis, 1992 Genotoxic chemicals can damage the genetic material of humans as well as that of organisms living in the environment. With respect to adverse effects, alterations induced in the germ line, leading to alterations in the genetic make-up of populations, are of primary concern in ecosystems, because somatic changes, even if they lead to a loss of ...
Würgler, F E, Kramers, P G N
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Biosynthesis and bioactivities of microbial genotoxin colibactins
Natural Product Reports, 2022 This review provides an update on biosynthesis and bioactivities of colibactin(s), the long-sought genotoxins produced by the pks island of Escherichia coli.
Jian-Wei Tang +4 more
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CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2021 ABSTRACT CYP1B1 activates many chemical carcinogens into potent genotoxins, and allelic variants are risk factors in lung, breast, and prostate cancer. However, genetic instability phenotypes incurred by CYP1B1-activated metabolites have been investigated for only few compounds.
Akaash Kannan +3 more
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Soritesidine, a Novel Proteinous Toxin from the Okinawan Marine Sponge Spongosorites sp.
Marine Drugs, 2019 A novel protein, soritesidine (SOR) with potent toxicity was isolated from the marine sponge Spongosorites sp. SOR exhibited wide range of toxicities over various organisms and cells including brine shrimp (Artemia salina) larvae, sea hare (Aplysia ...
Ryuichi Sakai +6 more
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Life, 2023 Bulgarian Rosa damascena Mill. is has been known since ancient times for its high-quality oil, hydrosol, and other aromatic products. Rose hydrosol has various biological activities, but no research on its anticytotoxic/antigenotoxic effects exists. This
Svetla Gateva +5 more
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Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells. [PDF]
PLoS ONE, 2013 Cellular senescence is an irreversible state of proliferation arrest evoked by a myriad of stresses including oncogene activation, telomere shortening/dysfunction and genotoxic insults. It has been associated with tumor activation, immune suppression and
Thomas Secher +3 more
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Detection of DNA damage by alkaline comet assay in mouse colonic mucosa
STAR Protocols, 2021 Summary: We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin.
Elisa Boutet-Robinet +4 more
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STAR Protocols, 2021 Summary: We recently characterized the association between DNA damage and immunoresponse in vivo in colonic mucosa of mice infected with a Salmonella Typhimurium strain expressing a genotoxin, known as typhoid toxin.
María López Chiloeches +3 more
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Frontiers in Cellular and Infection Microbiology, 2012 The cytolethal distending toxins (CDTs) comprise a family of intracellular-acting bacterial protein toxins whose actions upon eukaryotic cells result in several consequences, the most characteristic of which is the induction of G2/M cell cycle arrest ...
Amandeep eGargi +2 more
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