Results 31 to 40 of about 3,926 (200)
mSphere, 2021 Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal ...
Jean-Philippe Nougayrède +9 more
doaj +1 more source
Bio-Protocol, 2018 The genotoxin colibactin is produced by several species of Enterobacteriaceae. This genotoxin induces DNA damage, cell cycle arrest, senescence and death in eukaryotic cells (Nougayrède et al., 2006; Taieb et al., 2016).
Sophie Tronnet, Eric Oswald
doaj +1 more source
Cellular Senescence Triggered by Food and Environmental Genotoxins. [PDF]
Int J Mol SciCellular senescence (CSEN) is caused by a variety of factors that trigger complex molecular pathways. These include telomere shortening, oncogene activation and replicative stress, as well as DNA damage caused by genotoxic anticancer drugs and endogenous and exogenous genotoxins.
Kaina B, Tomicic MT, Christmann M.
europepmc +4 more sources
Functional and Structural Characterization of Chimeras of a Bacterial Genotoxin and Human Type I DNAse [PDF]
, 2009 Chimeras composed of the cdtB gene of a novel bacterial genotoxin and the human type I DNAse I gene were constructed and their products characterized relative to the biochemical and enzymatic properties of the native proteins. The product of a cdtB/DNAse
Cao, Linsen +6 more
core +1 more source
Caspase Regulation of Genotoxin-Induced Neural Precursor Cell Death
, 2003 Neural precursor cells (NPCs) critically regulate brain morphogenesis and recent studies have revealed an unexpectedly high frequency of NPC chromosomal abnormalities and apoptosis in the developing brain.
Lindsten, T +9 more
core +2 more sources
Soritesidine, a Novel Proteinous Toxin from the Okinawan Marine Sponge Spongosorites sp.
Marine Drugs, 2019 A novel protein, soritesidine (SOR) with potent toxicity was isolated from the marine sponge Spongosorites sp. SOR exhibited wide range of toxicities over various organisms and cells including brine shrimp (Artemia salina) larvae, sea hare (Aplysia ...
Ryuichi Sakai +6 more
doaj +1 more source
CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2021 ABSTRACT CYP1B1 activates many chemical carcinogens into potent genotoxins, and allelic variants are risk factors in lung, breast, and prostate cancer. However, genetic instability phenotypes incurred by CYP1B1-activated metabolites have been investigated for only few compounds.
Akaash Kannan +3 more
openaire +2 more sources
Life, 2023 Bulgarian Rosa damascena Mill. is has been known since ancient times for its high-quality oil, hydrosol, and other aromatic products. Rose hydrosol has various biological activities, but no research on its anticytotoxic/antigenotoxic effects exists. This
Svetla Gateva +5 more
doaj +1 more source
Bacterial genotoxins induce T cell senescence
Cell Reports, 2021 Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear.
Sarah L. Mathiasen +16 more
openaire +6 more sources