Results 11 to 20 of about 3,614 (202)
The Genotoxin Colibactin Shapes Gut Microbiota in Mice [PDF]
mSphere, 2020 The genotoxin colibactin produced by resident bacteria of the gut microbiota may have tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of colibactin on gut microbiota composition and functions remains unknown.
Sophie Tronnet +6 more
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Mechanisms of genotoxin-induced transcription and hypermutation in
Cancer Cell International, 2006 It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulates p53 transcription and the formation of ...
Burkala Evan +5 more
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Bacterial genotoxin functions as immune-modulator and promotes host survival [PDF]
Microbial Cell, 2016 Bacterial genotoxins are effectors that cause DNA damage in target cells. Many aspects of the biology of these toxins have been characterised in vitro, such as structure, cellular internalisation pathways and effects on the target cells.
Riccardo Guidi +2 more
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Bacterial genotoxins induce T cell senescence [PDF]
Cell Reports, 2021 Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear.
Sarah L. Mathiasen +16 more
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Delivery, structure, and function of bacterial genotoxins
Virulence, 2022 Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells.
Liaoqi Du, Jeongmin Song
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Bio-Protocol, 2018 The genotoxin colibactin is produced by several species of Enterobacteriaceae. This genotoxin induces DNA damage, cell cycle arrest, senescence and death in eukaryotic cells (Nougayrède et al., 2006; Taieb et al., 2016).
Sophie Tronnet, Eric Oswald
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Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.
PLoS Pathogens, 2013 In Escherichia coli, the biosynthetic pathways of several small iron-scavenging molecules known as siderophores (enterobactin, salmochelins and yersiniabactin) and of a genotoxin (colibactin) are known to require a 4'-phosphopantetheinyl transferase ...
Patricia Martin +12 more
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Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment
Toxins, 2020 Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative ...
Océane C.B. Martin, Teresa Frisan
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The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
mSphere, 2019 Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells.
Camille V. Chagneau +8 more
doaj +2 more sources
Frontiers in Microbiology, 2023 IntroductionPathogenic strains of Escherichia coli have been clearly identified as the causative agents of extraintestinal and diarrheal infections; however, the etiopathogenic role of E.
Juraj Bosák +8 more
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