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The Genotoxin Colibactin Shapes Gut Microbiota in Mice [PDF]
mSphere, 2020 The genotoxin colibactin produced by resident bacteria of the gut microbiota may have tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of colibactin on gut microbiota composition and functions remains unknown.
Sophie Tronnet +6 more
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Mechanisms of genotoxin-induced transcription and hypermutation in
Cancer Cell International, 2006 It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulates p53 transcription and the formation of ...
Burkala Evan +5 more
doaj +4 more sources
Bacterial genotoxin functions as immune-modulator and promotes host survival [PDF]
Microbial Cell, 2016 Bacterial genotoxins are effectors that cause DNA damage in target cells. Many aspects of the biology of these toxins have been characterised in vitro, such as structure, cellular internalisation pathways and effects on the target cells.
Riccardo Guidi +2 more
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Delivery, structure, and function of bacterial genotoxins
Virulence, 2022 Bacterial genotoxins are peptide or protein virulence factors produced by several pathogens, which make single-strand breaks (SSBs) and/or double-strand DNA breaks (DSBs) in the target host cells.
Liaoqi Du, Jeongmin Song
doaj +3 more sources
Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.
PLoS Pathogens, 2013 In Escherichia coli, the biosynthetic pathways of several small iron-scavenging molecules known as siderophores (enterobactin, salmochelins and yersiniabactin) and of a genotoxin (colibactin) are known to require a 4'-phosphopantetheinyl transferase ...
Patricia Martin +12 more
doaj +2 more sources
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
mSphere, 2019 Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells.
Camille V. Chagneau +8 more
doaj +2 more sources
A direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. [PDF]
, 2006 TopBP1-like proteins, which include Xenopus laevis Xmus101, are required for DNA replication and have been linked to replication checkpoint control. A direct role for TopBP1/Mus101 in checkpoint control has been difficult to prove, however, because of ...
Lindsay, Howard D. +2 more
core +5 more sources
Molecules, 2023 Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible.
Hanna Nikolaichuk +2 more
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Frontiers in Microbiology, 2023 IntroductionPathogenic strains of Escherichia coli have been clearly identified as the causative agents of extraintestinal and diarrheal infections; however, the etiopathogenic role of E.
Juraj Bosák +8 more
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Progress in the Study of Colorectal Cancer Caused by Altered Gut Microbiota After Cholecystectomy
Frontiers in Endocrinology, 2022 Epidemiological studies have found an increased incidence of colorectal cancer (CRC) in people who undergo cholecystectomy compared to healthy individuals.
Yanpeng Ma +13 more
doaj +1 more source