Results 11 to 20 of about 2,972 (172)

Intestinal bacteria and colorectal cancer: etiology and treatment

Gut Microbes, 2023
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecular signaling ...
Michael W. Dougherty, Christian Jobin
doaj   +1 more source

Cyclomodulins and Hemolysis in E. coli as Potential Low-Cost Non-Invasive Biomarkers for Colorectal Cancer Screening

Life, 2021
The frequent occurrence of E. coli positive for cyclomodulins such as colibactin (CLB), the cytotoxic necrotizing factor (CNF), and the cytolethal distending factor (CDT) in colorectal cancer (CRC) patients published so far provides the opportunity to ...
Kristýna Mezerová, Lubomír Starý, Pavel Zbořil, Ivo Klementa, Martin Stašek, Petr Špička, Pavel Skalický, Vladislav Raclavský   +7 more
doaj   +1 more source

Shining a Light on Colibactin Biology

Toxins, 2021
Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease
Michael W. Dougherty, Christian Jobin
doaj   +1 more source

Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden Root Products via High-Performance Thin-Layer Chromatography, Planar Assays, and High-Resolution Mass Spectrometry

Molecules, 2023
Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible.
Hanna Nikolaichuk, Irena M. Choma, Gertrud E. Morlock   +2 more
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Escherichia coli from biopsies differ in virulence genes between patients with colorectal neoplasia and healthy controls

Frontiers in Microbiology, 2023
IntroductionPathogenic strains of Escherichia coli have been clearly identified as the causative agents of extraintestinal and diarrheal infections; however, the etiopathogenic role of E.
Juraj Bosák, Darina Kohoutová, Darina Kohoutová, Matěj Hrala, Jitka Křenová, Paula Morávková, Stanislav Rejchrt, Jan Bureš, David Šmajs   +8 more
doaj   +1 more source

Progress in the Study of Colorectal Cancer Caused by Altered Gut Microbiota After Cholecystectomy

Frontiers in Endocrinology, 2022
Epidemiological studies have found an increased incidence of colorectal cancer (CRC) in people who undergo cholecystectomy compared to healthy individuals.
Yanpeng Ma, Yanpeng Ma, Ruize Qu, Ruize Qu, Yi Zhang, Yi Zhang, Changtao Jiang, Changtao Jiang, Changtao Jiang, Changtao Jiang, Zhipeng Zhang, Zhipeng Zhang, Wei Fu, Wei Fu   +13 more
doaj   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

Pathogenic Leptospira Evolved a Unique Gene Family Comprised of Ricin B-Like Lectin Domain-Containing Cytotoxins

Frontiers in Microbiology, 2022
Leptospirosis is a globally important neglected zoonotic disease. Previous data suggest that a family of virulence-modifying (VM) proteins (PF07598) is a distinctive feature of group I pathogenic Leptospira that evolved as important virulence ...
Reetika Chaurasia, Alan S. Marroquin, Joseph M. Vinetz, Michael A. Matthias   +3 more
doaj   +1 more source

Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases

mBio, 2022
Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs).
Noah P. Bradley, Katherine L. Wahl, Jacob L. Steenwyk, Antonis Rokas, Brandt F. Eichman   +4 more
doaj   +1 more source

Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research

Frontiers in Neuroscience, 2023
The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western Pacific ALS and a hotspot of sALS in the French Alps.
Peter S. Spencer, Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby, Emmeline Lagrange, B. Zane Horowitz, Raquel Valdes Angues, Jacques Reis, Jean-Paul Vernoux, Cédric Raoul, William Camu   +10 more
doaj   +1 more source