Results 21 to 30 of about 3,614 (202)

Progress in the Study of Colorectal Cancer Caused by Altered Gut Microbiota After Cholecystectomy

Frontiers in Endocrinology, 2022
Epidemiological studies have found an increased incidence of colorectal cancer (CRC) in people who undergo cholecystectomy compared to healthy individuals.
Yanpeng Ma, Yanpeng Ma, Ruize Qu, Ruize Qu, Yi Zhang, Yi Zhang, Changtao Jiang, Changtao Jiang, Changtao Jiang, Changtao Jiang, Zhipeng Zhang, Zhipeng Zhang, Wei Fu, Wei Fu   +13 more
doaj   +1 more source

Pathogenic Leptospira Evolved a Unique Gene Family Comprised of Ricin B-Like Lectin Domain-Containing Cytotoxins

Frontiers in Microbiology, 2022
Leptospirosis is a globally important neglected zoonotic disease. Previous data suggest that a family of virulence-modifying (VM) proteins (PF07598) is a distinctive feature of group I pathogenic Leptospira that evolved as important virulence ...
Reetika Chaurasia, Alan S. Marroquin, Joseph M. Vinetz, Michael A. Matthias   +3 more
doaj   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source

D-Serine reduces the expression of the cytopathic genotoxin colibactin

Microbial Cell, 2023
Some Escherichia coli strains harbour the pks island, a 54 kb genomic island en-coding the biosynthesis genes for a genotoxic compound named colibactin. In eukaryotic cells, colibactin can induce DNA damage, cell cycle arrest and chro-mosomal instability.
Jennifer C. Hallam, Sofia Sandalli, Iris Floria, Natasha C. A. Turner, Min Tang-Fichaux, Eric Oswald, Nicky O’Boyle, Andrew J. Roe   +7 more
doaj   +1 more source

A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling [PDF]

, 2022
Members of complex microbial communities that reside in environments such as the mammalian gut have evolved mechanisms of interspecies competition, which may be directed at resident microbial and host cells.
Ma, Amy, Chen, Jiandong, Jung, I-Ji, Alavi, Salma, Roggiani, Manuela, Tanchoco, Ethan, Liu, Rui, Pu, Qinqin, Beld, Joris, Byun, Hyuntae, Goulian, Mark, Zhu, Clara, Ma, Amy T., Hsiao, Ansel, Zhu, Jun, Degnan, Patrick, Zhu, Clara Y., Degnan, Patrick H.   +17 more
core   +1 more source

Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases

mBio, 2022
Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial biosynthetic gene clusters (BGCs).
Noah P. Bradley, Katherine L. Wahl, Jacob L. Steenwyk, Antonis Rokas, Brandt F. Eichman   +4 more
doaj   +1 more source

Early-onset, conjugal, twin-discordant, and clusters of sporadic ALS: Pathway to discovery of etiology via lifetime exposome research

Frontiers in Neuroscience, 2023
The identity and role of environmental factors in the etiology of sporadic amyotrophic lateral sclerosis (sALS) is poorly understood outside of three former high-incidence foci of Western Pacific ALS and a hotspot of sALS in the French Alps.
Peter S. Spencer, Peter S. Spencer, Valerie S. Palmer, Glen E. Kisby, Emmeline Lagrange, B. Zane Horowitz, Raquel Valdes Angues, Jacques Reis, Jean-Paul Vernoux, Cédric Raoul, William Camu   +10 more
doaj   +1 more source

Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells [PDF]

Mutagenesis, 2011
The conventional in vitro assays for genotoxicity assessment of chemicals are characterised by a high false-positive rate, thus failing to correctly predict their in vivo genotoxic effects. This study aimed to identify the cellular mechanisms induced by the false-positive genotoxins quercetin, 8-Hydroxyquinoline and 17-beta oestradiol in comparison to ...
Magkoufopoulou, C., Claessen, S. M. H., Jennen, D. G. J., Kleinjans, J. C. S., van Delft, J. H. M.   +4 more
openaire   +2 more sources

Influence of the microenvironment on modulation of the host response by typhoid toxin

Cell Reports, 2021
Summary: Bacterial genotoxins cause DNA damage in eukaryotic cells, resulting in activation of the DNA damage response (DDR) in vitro. These toxins are produced by Gram-negative bacteria, enriched in the microbiota of inflammatory bowel disease (IBD) and
Océane C.B. Martin, Anna Bergonzini, Maria Lopez Chiloeches, Eleni Paparouna, Deborah Butter, Sofia D.P. Theodorou, Maria M. Haykal, Elisa Boutet-Robinet, Toma Tebaldi, Andrew Wakeham, Mikael Rhen, Vassilis G. Gorgoulis, Tak Mak, Ioannis S. Pateras, Teresa Frisan   +14 more
doaj   +1 more source

A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917

mSphere, 2021
Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal ...
Jean-Philippe Nougayrède, Camille V. Chagneau, Jean-Paul Motta, Nadège Bossuet-Greif, Marcy Belloy, Frédéric Taieb, Jean-Jacques Gratadoux, Muriel Thomas, Philippe Langella, Eric Oswald   +9 more
doaj   +1 more source