Results 21 to 30 of about 2,972 (172)
Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells [PDF]
Mutagenesis, 2011 The conventional in vitro assays for genotoxicity assessment of chemicals are characterised by a high false-positive rate, thus failing to correctly predict their in vivo genotoxic effects. This study aimed to identify the cellular mechanisms induced by the false-positive genotoxins quercetin, 8-Hydroxyquinoline and 17-beta oestradiol in comparison to ...
Magkoufopoulou, C. +4 more
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Influence of the microenvironment on modulation of the host response by typhoid toxin
Cell Reports, 2021 Summary: Bacterial genotoxins cause DNA damage in eukaryotic cells, resulting in activation of the DNA damage response (DDR) in vitro. These toxins are produced by Gram-negative bacteria, enriched in the microbiota of inflammatory bowel disease (IBD) and
Océane C.B. Martin +14 more
doaj +1 more source
Bacterial genotoxin functions as immune-modulator and promotes host survival
Microbial Cell, 2016 Bacterial genotoxins are effectors that cause DNA damage in target cells. Many aspects of the biology of these toxins have been characterised in vitro, such as structure, cellular internalisation pathways and effects on the target cells.
Riccardo Guidi +2 more
doaj +1 more source
mSphere, 2021 Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal ...
Jean-Philippe Nougayrède +9 more
doaj +1 more source
Environmental effects of genotoxins (eco-genotoxicology) [PDF]
Mutagenesis, 1992 Genotoxic chemicals can damage the genetic material of humans as well as that of organisms living in the environment. With respect to adverse effects, alterations induced in the germ line, leading to alterations in the genetic make-up of populations, are of primary concern in ecosystems, because somatic changes, even if they lead to a loss of ...
Würgler, F E, Kramers, P G N
openaire +3 more sources
Bio-Protocol, 2018 The genotoxin colibactin is produced by several species of Enterobacteriaceae. This genotoxin induces DNA damage, cell cycle arrest, senescence and death in eukaryotic cells (Nougayrède et al., 2006; Taieb et al., 2016).
Sophie Tronnet, Eric Oswald
doaj +1 more source
Bacterial genotoxins induce T cell senescence
Cell Reports, 2021 Several types of pathogenic bacteria produce genotoxins that induce DNA damage in host cells. Accumulating evidence suggests that a central function of these genotoxins is to dysregulate the host's immune response, but the underlying mechanisms remain unclear.
Sarah L. Mathiasen +16 more
openaire +6 more sources
CYP1B1 converts procarcinogens into genotoxins in Saccharomyces cerevisiae [PDF]
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2021 ABSTRACT CYP1B1 activates many chemical carcinogens into potent genotoxins, and allelic variants are risk factors in lung, breast, and prostate cancer. However, genetic instability phenotypes incurred by CYP1B1-activated metabolites have been investigated for only few compounds.
Akaash Kannan +3 more
openaire +2 more sources
Soritesidine, a Novel Proteinous Toxin from the Okinawan Marine Sponge Spongosorites sp.
Marine Drugs, 2019 A novel protein, soritesidine (SOR) with potent toxicity was isolated from the marine sponge Spongosorites sp. SOR exhibited wide range of toxicities over various organisms and cells including brine shrimp (Artemia salina) larvae, sea hare (Aplysia ...
Ryuichi Sakai +6 more
doaj +1 more source
Life, 2023 Bulgarian Rosa damascena Mill. is has been known since ancient times for its high-quality oil, hydrosol, and other aromatic products. Rose hydrosol has various biological activities, but no research on its anticytotoxic/antigenotoxic effects exists. This
Svetla Gateva +5 more
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