Results 51 to 60 of about 3,926 (200)
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Toxicon, 2016 Escherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants are stably colonized by E. coli within a few days after birth. Certain E.
openaire +3 more sources
Cancer Nexus, EarlyView.Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang +7 more
wiley +1 more source
Development of genotoxin-exposed glands during pregnancy.
, 2012 (A, B) Analysis of lobulo-alveolar development during pregnancy. Whole mount preparations from timed pregnant mice (6d p.c, 10 week old mice), exposed as juveniles to DMBA (or not).
Soyoung Kim (117362) +2 more
core +1 more source
Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?
Biomolecules, 2015 The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-homologous small GTPases. It is well characterized as a membrane-bound signal transducing molecule that is involved in the regulation of cell motility and adhesion as well
Gerhard Fritz, Christian Henninger
doaj +1 more source
مجلة بغداد للعلوم, 2020 The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand ...
Mohammed T. Hussein +4 more
doaj +1 more source
From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
Frontiers in Immunology, 2021 Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis.
Yi-Ru Lai +16 more
doaj +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Gastrointestinal (GI) cancers, including esophageal (EC), gastric (GC), and colorectal cancer (CRC), impose a substantial global burden, with early detection remaining crucial for improving patient outcomes. The oral and gut microbiota are increasingly implicated in cancer development and hold promise as sources of non‐invasive biomarkers ...
Saidi Hu +12 more
wiley +1 more source
Genotoxins and the initiation of sporadic breast cancer [PDF]
Mutagenesis, 2001 Breast cancer is the most frequently diagnosed female malignancy world-wide. The aetiology of the majority of cases remains obscure and the only genotoxin as yet known to initiate breast cancer is ionizing radiation. High penetrance susceptibility genes probably account for no more than 5-10% of cases.
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Cytolethal distending toxin enhances Escherichia coli urinary tract infection
Infection and ImmunityCytolethal distending toxin (CDT) is a virulence factor produced by several gram-negative bacteria, including Escherichia coli, the most prevalent etiological agent of urinary tract infections (UTIs). CDT causes DNA damage to eukaryotic cells, leading to
Santosh Paudel +5 more
doaj +1 more source