Results 51 to 60 of about 3,614 (202)
, 2009 Chimeras composed of the cdtB gene of a novel bacterial genotoxin and the human type I DNAse I gene were constructed and their products characterized relative to the biochemical and enzymatic properties of the native proteins. The product of a cdtB/DNAse
Cao, Linsen +6 more
core +2 more sources
Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?
Biomolecules, 2015 The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the family of Ras-homologous small GTPases. It is well characterized as a membrane-bound signal transducing molecule that is involved in the regulation of cell motility and adhesion as well
Gerhard Fritz, Christian Henninger
doaj +1 more source
Development of genotoxin-exposed glands during pregnancy.
, 2012 (A, B) Analysis of lobulo-alveolar development during pregnancy. Whole mount preparations from timed pregnant mice (6d p.c, 10 week old mice), exposed as juveniles to DMBA (or not).
Soyoung Kim (117362) +2 more
core +1 more source
International Journal of Cancer, EarlyView.Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai +3 more
wiley +1 more source
From DNA Damage to Cancer Progression: Potential Effects of Cytolethal Distending Toxin
Frontiers in Immunology, 2021 Cytolethal distending toxin (CDT), one of the most important genotoxins, is produced by several gram-negative bacteria and is involved in bacterial pathogenesis.
Yi-Ru Lai +16 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley +1 more source
Genotoxins and the initiation of sporadic breast cancer [PDF]
Mutagenesis, 2001 Breast cancer is the most frequently diagnosed female malignancy world-wide. The aetiology of the majority of cases remains obscure and the only genotoxin as yet known to initiate breast cancer is ionizing radiation. High penetrance susceptibility genes probably account for no more than 5-10% of cases.
openaire +2 more sources
A direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. [PDF]
, 2006 TopBP1-like proteins, which include Xenopus laevis Xmus101, are required for DNA replication and have been linked to replication checkpoint control. A direct role for TopBP1/Mus101 in checkpoint control has been difficult to prove, however, because of ...
Lindsay, Howard D. +5 more
core +1 more source
Bio-Protocol, 2017 Strains of Escherichia coli bearing the pks genomic island synthesize the genotoxin colibactin. Exposure of eukaryotic cells to E. coli producing colibactin induces DNA damages, ultimately leading to cell cycle arrest, senescence and death.
Nadège Bossuet-Greif +4 more
doaj +1 more source
Dasatinib and quercetin prevent alveolar bone loss in aged mice
Journal of Periodontology, EarlyView.Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli +7 more
wiley +1 more source