Results 71 to 80 of about 2,972 (172)

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Nature Communications
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory phenotype (SASP) by damaging mitochondrial ...
Han-Yi Chen, Wan-Chen Hsieh, Yu-Chieh Liu, Huei-Ying Li, Po-Yo Liu, Yu-Ting Hsu, Shao-Chun Hsu, An-Chi Luo, Wei-Chen Kuo, Yi-Jhen Huang, Gan-Guang Liou, Meng-Yun Lin, Chun-Jung Ko, Hsing-Chen Tsai, Shu-Jung Chang   +14 more
doaj   +1 more source

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

mBio, 2018
Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island.
Nadège Bossuet-Greif, Julien Vignard, Frédéric Taieb, Gladys Mirey, Damien Dubois, Claude Petit, Eric Oswald, Jean-Philippe Nougayrède   +7 more
doaj   +1 more source

Variability in DNA repair and individual susceptibility to genotoxins

Clinical Chemistry, 1995
Abstract DNA repair is an important mechanism of cellular protection from the effects of genotoxic chemicals. Although extensive evidence from studies in experimental systems indicates that variation in DNA repair can significantly influence susceptibility to genotoxins, corresponding studies in human populations are so far limited ...
openaire   +3 more sources

Srs2 binding to proliferating cell nuclear antigen (PCNA) and its sumoylation contribute to replication protein A (RPA) antagonism during the DNA damage response

eLife
Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes to cope with genome stress. After prolonged genotoxin treatment, the checkpoint can be downregulated to allow cell cycle and growth resumption.
Jiayi Fan, Nalini Dhingra, Tammy Yang, Vicki Yang, Xiaolan Zhao   +4 more
doaj   +1 more source

The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin

mSphere, 2019
Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells.
Camille V. Chagneau, Christophe Garcie, Nadège Bossuet-Greif, Sophie Tronnet, Alexander O. Brachmann, Jörn Piel, Jean-Philippe Nougayrède, Patricia Martin, Eric Oswald   +8 more
doaj   +1 more source

Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.

PLoS Pathogens, 2013
In Escherichia coli, the biosynthetic pathways of several small iron-scavenging molecules known as siderophores (enterobactin, salmochelins and yersiniabactin) and of a genotoxin (colibactin) are known to require a 4'-phosphopantetheinyl transferase ...
Patricia Martin, Ingrid Marcq, Giuseppe Magistro, Marie Penary, Christophe Garcie, Delphine Payros, Michèle Boury, Maïwenn Olier, Jean-Philippe Nougayrède, Marc Audebert, Christian Chalut, Sören Schubert, Eric Oswald   +12 more
doaj   +1 more source

Apurinic/apyrimidinic endonuclease 1 prevents oxidative DNA damage in intestinal epithelial cells induced by genotoxic Escherichia coli NC101

Redox Biology
Background: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that regulates host responses to oxidative stress. We investigated its role in controlling DNA damage following infection with a genotoxic intestinal microbe.
Lindsay D. Butcher, Gerco den Hartog, Amber L. Ablack, Mason Matsubara, Leonid M. Rovner, David Rios-Covian, Taren Thron, Sarkis K. Mazmanian, Jailal N.G. Ablack, Thaddeus Stappenbeck, Lars Eckmann, Tadahide Izumi, Alina Tirla, Kevin M. Wernke, Seth B. Herzon, Michael W. Dougherty, Christian Jobin, Hiroshi Kiyono, Peter B. Ernst, Sheila E. Crowe   +19 more
doaj   +1 more source

Environmental and occupational genotoxins [PDF]

The Nucleus, 2019
Anita Mukherjee, Manosij Ghosh
openaire   +1 more source

A possible role of urinary genotoxic Escherichia coli in prostate cancer in Nigerian patients

BMC Research Notes
Objective Infection and inflammation are potential initiating factors for the development and progression of prostate cancer. This study investigated the presence of bacterial genotoxins; colibactin (clb) and cytolethal distending toxin (cdt) in ...
Sharon O. Akinpelu, Grace I. Olasehinde, Olayemi O. Akinnola   +2 more
doaj   +1 more source

Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide. [PDF]

Sci Rep
Akgün S, Naren P, Lenz T, Zink A, Krings KS, Wesselborg S, Mendiburo MJ, Prigione A, Stühler K, Stork B.   +9 more
europepmc   +1 more source