Results 71 to 80 of about 3,614 (202)
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
CA: A Cancer Journal for Clinicians, Volume 76, Issue 4, July/August 2026.Abstract This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends.
Hyuna Sung +7 more
wiley +1 more source
Environmental and Molecular Mutagenesis, Volume 67, Issue 5-7, June‐August 2026.ABSTRACT There is growing interest in in vitro‐based new approach methodologies (NAMs) for assessing genotoxicity. These approaches are desirable for industries like cosmetics which are prohibited from animal testing due to regulatory restrictions, as well as “3R” considerations to avoid in vivo testing.
Ashley Allemang, Stefan Pfuhler
wiley +1 more source
MATE transport of the E. coli-derived genotoxin colibactin [PDF]
Nature Microbiology, 2016 Various forms of cancer have been linked to the carcinogenic activities of microorganisms(1-3). The virulent gene island polyketide synthase (pks) produces the secondary metabolite colibactin, a genotoxic molecule(s) causing double-stranded DNA breaks(4) and enhanced colorectal cancer development(5,6).
Mousa, Jarrod J. +8 more
openaire +3 more sources
Journal of Separation Science, Volume 49, Issue 6, June 2026.ABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
Byungchan An +9 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Gut microbiome plays a crucial role in colorectal cancer development. The advanced sequencing techniques have the potential to complement current non‐invasive methods for early diagnosis and prevention of colorectal cancer. This includes conducting studies with robust statistical power and consistent, replicable methodologies, taking into consideration
Parvin Askari +10 more
wiley +1 more source
, 2017 The pks gene cluster encodes enzymes responsible for the synthesis of colibactin, a genotoxin that has been shown to induce DNA damage and contribute to increased virulence. The present study investigated the prevalence of pks in clinical K.
Jann-Tay Wang +10 more
core +3 more sources
Use of random amplified polymorphic DNA (RAPD) to detect DNA damage induced by Prangos ferulacea (Umbelliferae) essential oil against the Mediterranean flour moth Ephestia kuehniella Zeller (Lepidoptera: Pyralidae) [PDF]
Archives of Biological Sciences, 2015 DNA damage detection in Ephestia kuehniella by RAPD-PCR Abstract - The random amplified polymorphic DNA (RAPD) assay is a useful method for detecting genotoxin-induced DNA damage.
Ercan Fahriye Sumer
doaj +1 more source
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Whole‐genome sequencing of multidrug‐resistant Klebsiella pneumoniae from a neonatal ward environment in Chlef revealed persistent resistance genes and the clonal spread of high‐risk ST13. These findings highlight the hospital environment as a potential reservoir for transmission of resistant K. pneumoniae.
Meriem Derkaoui +7 more
wiley +1 more source
Molecular Microbiology, Volume 125, Issue 6, Page 475-492, June 2026.Toxigenic Salmonella enterica exocytose the typhoid toxin during infection causing host cell DNA damage, which activates a Type‐1 Interferon‐like response characterised by interferon‐stimulated gene 15 (ISG15) expression. ISG15 was required for host cell survival during Interferon responses and suppressed intracellular growth of Salmonella. Thus, ISG15
Daniel S. Stark +11 more
wiley +1 more source