Results 71 to 80 of about 3,926 (200)

The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli

, 2014
International audienceSepsis is a life-threatening infection. Escherichia coli is the first known cause of bacteremia leading to sepsis. Lymphopenia was shown to predict bacteremia better than conventional markers of infection.
Nougayrède, Jean-Philippe, Cuevas-Ramos, Gabriel, Oswald, Eric, Martin, Patricia, Boury, Michèle, I. Marcq, C. Watrin, P. Martin, Watrin, Claude, Olier, Maïwenn, E. Oswald, D. Payros, M. Boury, M. Olier, G. Cuevas-Ramos, J.-P. Nougayrede, Marcq, Ingrid, Payros, Delphine   +17 more
core   +1 more source

Mapping Mutations and Signaling Network Interactions to Guide Precision Therapy in Gallbladder Cancer

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav, Akanksha Kashyap, Lakshay Malhotra, Chethan Rajegowda, Chandra Prakash Prasad   +4 more
wiley   +1 more source

Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

, 2015
International audienceThe intestinal barrier controls the balance between tolerance and immunity to luminal antigens. When this finely tuned equilibrium is deregulated, inflammatory disorders can occur.
Brehin, Camille, Secher, Thomas, Saoudi, Abdelhadi, Oswald, Eric, Bernard-Cadenat, Isabelle, Gillet, Marion, Ménard, Sandrine, Boury, Michèle, Watrin, Claude, Olier, Maïwenn, Payros, Delphine, Theodorou, Vassilia   +11 more
core   +1 more source

The human gut bacterial genotoxin colibactin alkylates DNA

, 2020
Certain Escherichia coli strains residing in the human gut produce colibactin, a small-molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects ...
Ngo, Lizzie, Engelward, Bevin P., Samson, Leona D.   +2 more
core   +1 more source

Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Dysbiosis of the gastrointestinal microbiome plays a role in carcinogenesis by inducing chronic inflammation, DNA damage, and activation of signaling pathways such as NF‐κB, STAT3, and Wnt/β‐catenin. Microorganisms such as Helicobacter pylori, Fusobacterium nucleatum, and Bacteroides fragilis promote the development of gastrointestinal tumors through ...
Negar Asgari, Mehrasa Asghari, Touraj Farazmandfar   +2 more
wiley   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source

Genotoxin Effect of Composite Resin

Indonesian Journal of Legal and Forensic Sciences (IJLFS), 2019
At this moment composite resin is the most widely used material for dental restoration. The content of the resin is a mixture of monomer bisphenol A glycidyl methacrylate (Bis-GMA), trimethylene glycol dimethylmethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) and special particle fillers made of radioopaque glass.
Elza Ibrahim Auerkari, Tienneke Riana Septiwidyati   +1 more
openaire   +2 more sources

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source

The genotoxin colibactin

, 2014
National audienceEscherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants
Nougayrède, Jean-Philippe
core   +1 more source

Biological Activities, Medicinal Uses, and Nutritional Effects of Terminalia arjuna (Roxb. ex DC.) Wight & Arn.: Phytochemical Insights and Therapeutic Benefits in Ulcerative Colitis Management—A Detailed Review

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
This graphical abstract highlights the versatile therapeutic potential and food applications of Terminalia arjuna, centering on its broad health‐promoting bioactivities. Key mechanisms described include adaptogenic, cardioprotective, gastroprotective, wound‐healing, and anti‐inflammatory effects mediated through Nrf2 and NF‐κB signaling pathways ...
Rameen Naeem, Muhammad Tauseef Sultan, Muhammad Usman Khalid, Muhammad Maaz, Ayman Furqan, Laiba Tanvir, Fabiano Travaglia, Matteo Bordiga, Mutjardah Zarrish   +8 more
wiley   +1 more source