Results 91 to 100 of about 3,926 (200)

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

mBio, 2018
Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island.
Nadège Bossuet-Greif, Julien Vignard, Frédéric Taieb, Gladys Mirey, Damien Dubois, Claude Petit, Eric Oswald, Jean-Philippe Nougayrède   +7 more
doaj   +1 more source

Occurrence and Control of Genotoxins in Drinking Water: A Monitoring Proposal

Journal of Public Health Research, 2016
Many studies have shown the presence of numerous organic genotoxins and carcinogens in drinking water. These toxic substances derive not only from pollution, but also from the disinfection treatments, particularly when water is obtained from surface sources and then chlorinated.
CERETTI, Elisabetta, Moretti, Massimo, ZERBINI, Ilaria, Villarini, Milena, ZANI, Claudia, Monarca, Silvano, FERETTI, Donatella   +6 more
openaire   +5 more sources

The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic Infection. [PDF]

, 2015
Escherichia coli strains expressing the K1 capsule are a major cause of sepsis and meningitis in human neonates. The development of these diseases is dependent on the expression of a range of virulence factors, many of which remain uncharacterized. Here,
Taylor, Peter W, Mccarthy, Alex J., Stabler, Richard A., Taylor, PW, Oswald, Eric, Martin, Patricia, Cloup, E, Taylor, Peter W., Cloup, Emilie, McCarthy, AJ, Stabler, R, Stabler, Richard A, Oswald, E, Martin, P, McCarthy, Alex J   +14 more
core   +1 more source

Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages

, 2011
Cytolethal distending toxin (CDT) is a heterotrimeric AB-type genotoxin produced by several clinically important Gram-negative mucocutaneous bacterial pathogens.
Rasika N. Jinadasa, Gerald E. Duhamel, Robert S. Weiss, Stephen E. Bloom   +3 more
core   +1 more source

Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment

, 2020
Bacterial genotoxins (BTGX) induce DNA damage, which results in senescence or apoptosis of the target cells if not properly repaired. Three BTGXs have been identified: the cytolethal distending toxin (CDT) family produced by several Gram-negative ...
Frisan, Teresa, Frisan, T,, Martin, OCB, Frisan, Teresa,, Océane C.B. Martin, Teresa Frisan, Martin, Oceane C. B.   +6 more
core   +1 more source

Srs2 binding to proliferating cell nuclear antigen (PCNA) and its sumoylation contribute to replication protein A (RPA) antagonism during the DNA damage response

eLife
Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes to cope with genome stress. After prolonged genotoxin treatment, the checkpoint can be downregulated to allow cell cycle and growth resumption.
Jiayi Fan, Nalini Dhingra, Tammy Yang, Vicki Yang, Xiaolan Zhao   +4 more
doaj   +1 more source

Cell growth, genotoxin sensitivity and chromosome segregation in slx8 Δ and pli1Δ single and double mutants.

, 2013
(A) Spot assay comparing the genotoxin sensitivities of strains MCW1221, MCW4568, MCW4688 and FO986. Plates were photographed after 6 days growth at 30°C. (B) Spot assay comparing the growth at different temperatures of the same strains as in A.
Fekret Osman (264539), Alexander Lorenz (442220), Roland Steinacher (442219), Matthew C. Whitby (7384), Claire Bryer (442221)   +4 more
core   +1 more source

Evaluation of the DNA damage response (DDR) in basal and luminal epithelial cells after genotoxin administration in vivo.

, 2012
(A) DNA damage focus assembly. Mice were treated with either 10 Gy γ-irradiation and harvested 30 minutes later (positive control), or administered DMBA (2 µg/ml) or vehicle (tricaprylin), and their mammary glands were harvested 2 days or 7 weeks later ...
Soyoung Kim (117362), Kristine S. Klos (117361), Caroline M. Alexander (117364)   +2 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells

, 2004
Treatment of many cancers relies on the combined action of several genotoxins, but the detrimental effect of these drugs on normal cells can cause severe side effects.
Bonny, C., Yang, J. Y., Chen, J., Michod, D., Widmann, C.   +4 more
core   +1 more source