Results 91 to 100 of about 3,614 (202)

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition

, 2022
Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing.
Chong, Kelvin K. L., Ho, Foo Kiong, Keogh, Damien, Ho, Benjamin Chee Meng, Chen, John, Chong, Kelvin Kian Long, Barkham, Timothy, Kline, Kimberly Ann, Ho, Chee Meng Benjamin, Neelakandan, Ramesh, Liu, Chuan Fa, Kline, Kimberly A., Choo, Pei Yi, Wong, Jun Jie, Chong, Kelvin K L   +14 more
core   +1 more source

The genotoxin colibactin

, 2014
National audienceEscherichia coli is a commensal inhabitant of the lower gastrointestinal tract of humans where it is the predominant facultative anaerobic organism. E. coli also belongs to the initial microbiota that colonizes the mammalian gut. Infants
Nougayrède, Jean-Philippe
core  

Occurrence and Control of Genotoxins in Drinking Water: A Monitoring Proposal

Journal of Public Health Research, 2016
Many studies have shown the presence of numerous organic genotoxins and carcinogens in drinking water. These toxic substances derive not only from pollution, but also from the disinfection treatments, particularly when water is obtained from surface sources and then chlorinated.
CERETTI, Elisabetta, Moretti, Massimo, ZERBINI, Ilaria, Villarini, Milena, ZANI, Claudia, Monarca, Silvano, FERETTI, Donatella   +6 more
openaire   +5 more sources

Cell growth, genotoxin sensitivity and chromosome segregation in slx8 Δ and pli1Δ single and double mutants.

, 2013
(A) Spot assay comparing the genotoxin sensitivities of strains MCW1221, MCW4568, MCW4688 and FO986. Plates were photographed after 6 days growth at 30°C. (B) Spot assay comparing the growth at different temperatures of the same strains as in A.
Fekret Osman (264539), Alexander Lorenz (442220), Roland Steinacher (442219), Matthew C. Whitby (7384), Claire Bryer (442221)   +4 more
core   +1 more source

Variability in DNA repair and individual susceptibility to genotoxins

Clinical Chemistry, 1995
Abstract DNA repair is an important mechanism of cellular protection from the effects of genotoxic chemicals. Although extensive evidence from studies in experimental systems indicates that variation in DNA repair can significantly influence susceptibility to genotoxins, corresponding studies in human populations are so far limited ...
openaire   +3 more sources

Evaluation of the DNA damage response (DDR) in basal and luminal epithelial cells after genotoxin administration in vivo.

, 2012
(A) DNA damage focus assembly. Mice were treated with either 10 Gy γ-irradiation and harvested 30 minutes later (positive control), or administered DMBA (2 µg/ml) or vehicle (tricaprylin), and their mammary glands were harvested 2 days or 7 weeks later ...
Soyoung Kim (117362), Kristine S. Klos (117361), Caroline M. Alexander (117364)   +2 more
core   +1 more source

Srs2 binding to proliferating cell nuclear antigen (PCNA) and its sumoylation contribute to replication protein A (RPA) antagonism during the DNA damage response

eLife
Activation of the DNA damage checkpoint upon genotoxin treatment induces a multitude of cellular changes to cope with genome stress. After prolonged genotoxin treatment, the checkpoint can be downregulated to allow cell cycle and growth resumption.
Jiayi Fan, Nalini Dhingra, Tammy Yang, Vicki Yang, Xiaolan Zhao   +4 more
doaj   +1 more source

Loss of Mdb1 alters genotoxin sensitivity of crb2 and set9 mutants.

, 2014
(A) mdb1Δ alters the genotoxin sensitivity of crb2Δ in a manner similar to htaAQ. Strains used were LD327, LD1067, LD574, LD197, LD1068, LD1070, LD678, and LD1071.
Hai-Tao Wang (561009), Yonggong Zhai (49703), Paul Russell (154255), Yi Wei (434518), Li-Lin Du (154264)   +4 more
core   +1 more source

Apurinic/apyrimidinic endonuclease 1 prevents oxidative DNA damage in intestinal epithelial cells induced by genotoxic Escherichia coli NC101

Redox Biology
Background: Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that regulates host responses to oxidative stress. We investigated its role in controlling DNA damage following infection with a genotoxic intestinal microbe.
Lindsay D. Butcher, Gerco den Hartog, Amber L. Ablack, Mason Matsubara, Leonid M. Rovner, David Rios-Covian, Taren Thron, Sarkis K. Mazmanian, Jailal N.G. Ablack, Thaddeus Stappenbeck, Lars Eckmann, Tadahide Izumi, Alina Tirla, Kevin M. Wernke, Seth B. Herzon, Michael W. Dougherty, Christian Jobin, Hiroshi Kiyono, Peter B. Ernst, Sheila E. Crowe   +19 more
doaj   +1 more source

A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells

, 2004
Treatment of many cancers relies on the combined action of several genotoxins, but the detrimental effect of these drugs on normal cells can cause severe side effects.
Bonny, C., Yang, J. Y., Chen, J., Michod, D., Widmann, C.   +4 more
core   +1 more source