Results 101 to 110 of about 3,614 (202)

The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic Infection.

, 2015
Escherichia coli strains expressing the K1 capsule are a major cause of sepsis and meningitis in human neonates. The development of these diseases is dependent on the expression of a range of virulence factors, many of which remain uncharacterized. Here,
Taylor, Peter W, Mccarthy, Alex J., Stabler, Richard A., Taylor, PW, Oswald, Eric, Martin, Patricia, Cloup, E, Taylor, Peter W., Cloup, Emilie, McCarthy, AJ, Stabler, R, Stabler, Richard A, Oswald, E, Martin, P, McCarthy, Alex J   +14 more
core   +2 more sources

Simultaneous detection of nucleotide excision repair events and apoptosis-induced DNA fragmentation in genotoxin-treated cells

, 2018
Novel in vivo excision assays for monitoring the excised oligonucleotide products of nucleotide excision repair in UV-irradiated cells have provided unprecedented views of the kinetics and genomic distribution of repair events.
Sueji Han, Jun-Hyuk Choi, Soyun Baek, Dukjin Kang, Michael G. Kemp   +4 more
core   +1 more source

Interplay Between Siderophores and Colibactin Genotoxin in Escherichia coli

, 2017
International audienceHighly pathogenic Escherichia coli strains that belong to the phylogenetic group B2 have developed a greater ability to acquire iron (heme receptor and numerous siderophores), to produce the genotoxin colibactin and to synthesize ...
Garcie, Christophe, Sophie Tronnet, Tronnet, Sophie, Christophe Garcie, Oswald, Eric, Martin, Patricia, Patricia Martin, Eric Oswald   +7 more
core   +1 more source

Environmental and occupational genotoxins [PDF]

The Nucleus, 2019
Anita Mukherjee, Manosij Ghosh
openaire   +1 more source

Abstract LB-101: A novel role of semaphorin4a (sema4a) in genotoxin-induced DNA damage response in human lung fibroblasts

, 2010
Dysregulation of DNA repair signaling after genotoxin exposure contributes to genomic instability and carcinogenesis. Hexavalent chromium [Cr(VI)] is a genotoxin of occupational and environmental concern.
Gina Chun, Dongsoon Bae, Steven R. Patierno, Susan M. Ceryak   +3 more
core   +1 more source

Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway

, 2002
The evolutionarily conserved Hus1 proteins function in DNA damage response pathways that serve to maintain genomic stability [1, 2]. Cells lacking mouse Hus1 are hypersensitive to certain genotoxins [3], and we have explored the molecular basis for this ...
Leder, Philip, Matsuoka, Shuhei, Elledge, Stephen J., Weiss, Robert S.   +3 more
core   +1 more source

A possible role of urinary genotoxic Escherichia coli in prostate cancer in Nigerian patients

BMC Research Notes
Objective Infection and inflammation are potential initiating factors for the development and progression of prostate cancer. This study investigated the presence of bacterial genotoxins; colibactin (clb) and cytolethal distending toxin (cdt) in ...
Sharon O. Akinpelu, Grace I. Olasehinde, Olayemi O. Akinnola   +2 more
doaj   +1 more source

Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide. [PDF]

Sci Rep
Akgün S, Naren P, Lenz T, Zink A, Krings KS, Wesselborg S, Mendiburo MJ, Prigione A, Stühler K, Stork B.   +9 more
europepmc   +1 more source

A Review of Susceptibility Factors for Colibactin-Associated Colorectal Cancer in African Populations. [PDF]

Cureus
Badero OJ, Ikedionwu OI, Ajayi V, Jemiseye AV.   +3 more
europepmc   +1 more source

Use of a second, statistically based (Q)SAR (Quantitative Structure Activity Relationships)methodology in Genotoxin Risk Assessment (GRA)assessment of DNA reactive (mutagenic) impurities: Challenges and Opportunities

, 2014
The proposed ICH (International Conference on Harmonization) guidance on genotoxic DNA reactive (mutagenic) impurities (ICH M7) has recently received step 2 approval (1).
Glowienke, Susanne, Marterer, Wolfgang
core