Results 81 to 90 of about 3,614 (202)

Gut Microbiota: A Potential Role in Modulating Carcinogenesis and Response to Anti‐Cancer Therapies

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background The effects of microbiota on cancer are not only limited to their role in oncogenesis, progression and response to anticancer therapies; the disease itself is also influenced by microbiota. In recent investigations, alterations in the gut bacterial community between cancer patients and healthy individuals have been reported ...
Awgichew Shewasinad Yehualashet, Eleni Teklu Fersha, Berhan Begashaw Yikna, Kassahun Dires Ayenew   +3 more
wiley   +1 more source

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

mBio, 2018
Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island.
Nadège Bossuet-Greif, Julien Vignard, Frédéric Taieb, Gladys Mirey, Damien Dubois, Claude Petit, Eric Oswald, Jean-Philippe Nougayrède   +7 more
doaj   +1 more source

Probiotics Cancer Interaction, Prevention, and Therapy

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Cancer is a significant global health concern and ranks as the second most common cause of death on a worldwide scale. A combination of hereditary and lifestyle variables, such as diet, smoking, alcohol consumption, physical exercise, and the gut microbiota, impacts cancer development. Dysbiosis, an imbalance in gut microorganisms, can promote
Mostafa Saebi, Amir Hossein Barjasteh, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Setayesh Ramazanpour, Negar Ebadpour, Afsane Fadaee, Seyed‐Alireza Esmaeili   +7 more
wiley   +1 more source

Estragole:a weak direct-acting food-borne genotoxin and potential carcinogen

, 2012
We evaluated the genotoxicity of the food-flavouring agent estragole in V79 cells using the sister chromatid exchange (SCE) assay and the alkaline comet assay. Unexpectedly, we observed an increase in SCE without an exogenous biotransformation system (S9)
Phillips, David H, Cole, Kathleen J, Rueff, José, Cação, Raquel, Rodrigues, António S, Martins, Célia, Laires, António   +6 more
core   +1 more source

Host Factor Induced Bacterial Extracellular Vesicles Promote Horizontal Gene Transfer in Vibrio cholerae

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Antimicrobial stressors, that is, bile or mitomycin C, induce enlarged, nucleic acid‐rich bacterial extracellular vesicles in Vibrio cholerae that facilitate horizontal gene transfer in vitro and during intestinal colonisation. The findings provide a detailed comparison of control versus stress‐induced vesicles, identify bile as a host factor shaping ...
Dominik Fleischhacker, Yi‐Chi Chen, Noa Sanchez Gordo, Amar Cosic, Ratchara Kalwong, Leo Eberl, Stefan Schild   +6 more
wiley   +1 more source

Familial Adenomatous Polyposis—Risk of Cancer, Cancer Prevention, and Long‐Term Consequences: Learnings from Five Decades with the Danish Polyposis Register

APMIS, Volume 134, Issue 5, May 2026.
ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley   +1 more source

TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis

Cell Reports
Summary: TREX2, a 3′-5′ exonuclease, is a part of the DNA damage tolerance (DDT) pathway that stabilizes replication forks (RFs) by ubiquitinating PCNA along with the ubiquitin E3 ligase RAD18 and other DDT factors.
Teresa Marple, Mi Young Son, Xiaodong Cheng, Jun Ho Ko, Patrick Sung, Paul Hasty   +5 more
doaj   +1 more source

A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect

, 2019
A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response ...
R Savarirayan (9956687), P Kalitsis (13503967), R Vasireddy (15794879), S Kozlov (15794876), Y Yan (7710119), MJ McKay (15791906), H Xu (4701343), S Verschoor (2570848), P Lobachevsky (13688200), J Ryan (6851792), Jeffrey Craig (13065240), RG Ramsay (15336391), P Chen (2934000), MF Lavin (14457291), G McGillivray (15794882)   +14 more
core  

Sequence Variability of P2-Like Prophage Genomes Carrying the Cytolethal Distending Toxin V Operon in Escherichia coli O157

, 2013
Cytolethal distending toxins (CDT) are potent cytotoxins of several Gram-negative pathogenic bacteria, including Escherichia coli, in which five types (CDT-I to CDT-V) have been identified so far.
Dobrindt, Ulrich, Maróti, Gergely, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
core   +1 more source

Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages

, 2011
Cytolethal distending toxin (CDT) is a heterotrimeric AB-type genotoxin produced by several clinically important Gram-negative mucocutaneous bacterial pathogens.
Rasika N. Jinadasa, Gerald E. Duhamel, Robert S. Weiss, Stephen E. Bloom   +3 more
core   +1 more source