Results 81 to 90 of about 3,926 (200)

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, Volume 97, Issue 9, Page 1965-1979, September 2026.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Dietary Terpenoids in Advancing Biofilm‐Mediated Cancer Prevention: Antibiofilm Cascade, Molecular Crosstalk, and Nano‐Facilitated Functional Delivery

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Saikat Mazumder, Aditi Dey, Debasmita Bhattacharya, Dibyajit Lahiri, Moupriya Nag, Sudhriti Maity, Navin Kumar, Soumya Pandit, Vaseem Raja, Shubham Sharma, Shashi Prakash Dwivedi, Mithul Rajeev, Juwita Ratna Dewi, Lola Sanayeva, Dilbar Azimova   +14 more
wiley   +1 more source

Prevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in Taiwan

, 2017
The pks gene cluster encodes enzymes responsible for the synthesis of colibactin, a genotoxin that has been shown to induce DNA damage and contribute to increased virulence. The present study investigated the prevalence of pks in clinical K.
Jann-Tay Wang, Yih-Ru Shiau, Ann-Chi Lin, Mei-Chen Tan, Yi-Chyi Lai, I-Wen Huang, Hui-Ying Wang, Jui-Fen Lai, Tsai-Ling Lauderdale, Ying-Tsong Chen, Li-Yun Hsieh   +10 more
core   +3 more sources

The gut microbiome organ

iMeta, Volume 5, Issue 4, August 2026.
The gut microbiome can be conceptualized as a distributed organ‐like functional system with spatially structured organization, broad biochemical capacity, and continuous bidirectional communication with the host. By transforming dietary, host‐derived, and environmental substrates into bioactive metabolites with endocrine‐like, immunomodulatory, and ...
Yang Bi, Weibin Song, Maria Glymenaki, Jie Hu, Xiru Li, Heng Huang, Yousong Peng, Shuaishuai Ni, Ornuma Haonon, Zhu Liu, Krai Daowtak, Xiaotao Shen, Huadong Peng, Jutarop Phetcharaburanin, Huiru Tang, Yulan Wang, Jia V. Li, Mizu Jiang, Nick Powell, Victor W. Zhong, Elaine Holmes, Yunlei Xianyu, Zhigang Liu   +22 more
wiley   +1 more source

Estragole:a weak direct-acting food-borne genotoxin and potential carcinogen

, 2012
We evaluated the genotoxicity of the food-flavouring agent estragole in V79 cells using the sister chromatid exchange (SCE) assay and the alkaline comet assay. Unexpectedly, we observed an increase in SCE without an exogenous biotransformation system (S9)
Phillips, David H, Cole, Kathleen J, Rueff, José, Cação, Raquel, Rodrigues, António S, Martins, Célia, Laires, António   +6 more
core   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis

Cell Reports
Summary: TREX2, a 3′-5′ exonuclease, is a part of the DNA damage tolerance (DDT) pathway that stabilizes replication forks (RFs) by ubiquitinating PCNA along with the ubiquitin E3 ligase RAD18 and other DDT factors.
Teresa Marple, Mi Young Son, Xiaodong Cheng, Jun Ho Ko, Patrick Sung, Paul Hasty   +5 more
doaj   +1 more source

Variability in DNA repair and individual susceptibility to genotoxins

Clinical Chemistry, 1995
Abstract DNA repair is an important mechanism of cellular protection from the effects of genotoxic chemicals. Although extensive evidence from studies in experimental systems indicates that variation in DNA repair can significantly influence susceptibility to genotoxins, corresponding studies in human populations are so far limited ...
openaire   +3 more sources

A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response Defect

, 2019
A Roberts Syndrome Individual With Differential Genotoxin Sensitivity and a DNA Damage Response ...
R Savarirayan (9956687), P Kalitsis (13503967), R Vasireddy (15794879), S Kozlov (15794876), Y Yan (7710119), MJ McKay (15791906), H Xu (4701343), S Verschoor (2570848), P Lobachevsky (13688200), J Ryan (6851792), Jeffrey Craig (13065240), RG Ramsay (15336391), P Chen (2934000), MF Lavin (14457291), G McGillivray (15794882)   +14 more
core