Results 61 to 70 of about 3,926 (200)

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin

, 2023
International audienceThe genotoxin colibactin produced by Escherichia coli is involved in the development of colorectal cancers. This secondary metabolite is synthesized by a multi-protein machinery, mainly composed of non-ribosomal peptide synthetase ...
Pauline Macheboeuf, Andréa Dessen, Bonhomme, Sarah, Macheboeuf, Pauline, Dessen, Andréa, Contreras-Martel, Carlos, Sarah Bonhomme, Carlos Contreras-Martel   +7 more
core   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source

Sequence Variability of P2-Like Prophage Genomes Carrying the Cytolethal Distending Toxin V Operon in Escherichia coli O157 [PDF]

, 2013
Cytolethal distending toxins (CDT) are potent cytotoxins of several Gram-negative pathogenic bacteria, including Escherichia coli, in which five types (CDT-I to CDT-V) have been identified so far.
Dobrindt, Ulrich, Maróti, Gergely, Sváb, Domonkos, Horváth, Balázs, Tóth, István   +4 more
core   +1 more source

Protocol for HeLa Cells Infection with Escherichia coli Strains Producing Colibactin and Quantification of the Induced DNA-damage

Bio-Protocol, 2017
Strains of Escherichia coli bearing the pks genomic island synthesize the genotoxin colibactin. Exposure of eukaryotic cells to E. coli producing colibactin induces DNA damages, ultimately leading to cell cycle arrest, senescence and death.
Nadège Bossuet-Greif, Marcy Belloy, Michèle Boury, Eric Oswald, Jean-Philippe Nougayrede   +4 more
doaj   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells.

, 2009
The crypt-villi axis of intestinal mucosa maintains homeostasis by renewal of epithelia, and also exhibits different properties from undifferentiated to terminally differentiated cells.
채보아, 김태일, 양경민, 김원호   +3 more
core   +1 more source

Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.

PLoS ONE, 2012
Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure.
Vincent Paget, Mathilde Lechevrel, Véronique André, Jérémie Le Goff, Didier Pottier, Sylvain Billet, Guillaume Garçon, Pirouz Shirali, François Sichel   +8 more
doaj   +1 more source

Analysis of the role of the Fun30 CUE motif in genotoxin resistance.

, 2015
(A) Schematic of Fun30 protein. The CUE motif and ATPase domain are indicated. (B) The CUE motif of Fun30 is not required for genotoxin resistance. Growth phenotypes of strains 89 through 93 on indicated media are shown. Note pRS414-FUN30-CUE** encodes a
Ali Khan (568900), Jasmine Siler (711498), Chong Li (120471), Qun Yu (164003), Xin Bi (164009)   +4 more
core   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, Volume 159, Issue 8, Page 1928-1936, 15 October 2026.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source