Results 61 to 70 of about 3,614 (202)

Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells.

, 2009
The crypt-villi axis of intestinal mucosa maintains homeostasis by renewal of epithelia, and also exhibits different properties from undifferentiated to terminally differentiated cells.
채보아, 김태일, 양경민, 김원호   +3 more
core   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

The human gut bacterial genotoxin colibactin alkylates DNA

, 2020
Certain Escherichia coli strains residing in the human gut produce colibactin, a small-molecule genotoxin implicated in colorectal cancer pathogenesis. However, colibactin’s chemical structure and the molecular mechanism underlying its genotoxic effects ...
Ngo, Lizzie, Engelward, Bevin P., Samson, Leona D.   +2 more
core   +1 more source

Benzo[a]pyrene, aflatoxine B₁ and acetaldehyde mutational patterns in TP53 gene using a functional assay: relevance to human cancer aetiology.

PLoS ONE, 2012
Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure.
Vincent Paget, Mathilde Lechevrel, Véronique André, Jérémie Le Goff, Didier Pottier, Sylvain Billet, Guillaume Garçon, Pirouz Shirali, François Sichel   +8 more
doaj   +1 more source

Compromised DNA replication in gut cells underlies sensitivity to genotoxic stress in the tardigrade Hypsibius exemplaris

The FEBS Journal, EarlyView.
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non‐replicating cells tolerate genotoxic stress, constitutively replicating cells undergo irreversible replication failure upon DNA damage, leading to loss of tissue homeostasis, fat depletion, sterility, and organismal death ...
Gonzalo Quiroga‐Artigas, Pauline Fontanié, Benjamin Lacroix, Maria Dolores Molina, María Moriel‐Carretero   +4 more
wiley   +1 more source

Analysis of the role of the Fun30 CUE motif in genotoxin resistance.

, 2015
(A) Schematic of Fun30 protein. The CUE motif and ATPase domain are indicated. (B) The CUE motif of Fun30 is not required for genotoxin resistance. Growth phenotypes of strains 89 through 93 on indicated media are shown. Note pRS414-FUN30-CUE** encodes a
Ali Khan (568900), Jasmine Siler (711498), Chong Li (120471), Qun Yu (164003), Xin Bi (164009)   +4 more
core   +1 more source

The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli

, 2014
International audienceSepsis is a life-threatening infection. Escherichia coli is the first known cause of bacteremia leading to sepsis. Lymphopenia was shown to predict bacteremia better than conventional markers of infection.
Nougayrède, Jean-Philippe, Cuevas-Ramos, Gabriel, Oswald, Eric, Martin, Patricia, Boury, Michèle, I. Marcq, C. Watrin, P. Martin, Watrin, Claude, Olier, Maïwenn, E. Oswald, D. Payros, M. Boury, M. Olier, G. Cuevas-Ramos, J.-P. Nougayrede, Marcq, Ingrid, Payros, Delphine   +17 more
core   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Genotoxin Effect of Composite Resin

Indonesian Journal of Legal and Forensic Sciences (IJLFS), 2019
At this moment composite resin is the most widely used material for dental restoration. The content of the resin is a mixture of monomer bisphenol A glycidyl methacrylate (Bis-GMA), trimethylene glycol dimethylmethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) and special particle fillers made of radioopaque glass.
Elza Ibrahim Auerkari, Tienneke Riana Septiwidyati   +1 more
openaire   +2 more sources

Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

, 2015
International audienceThe intestinal barrier controls the balance between tolerance and immunity to luminal antigens. When this finely tuned equilibrium is deregulated, inflammatory disorders can occur.
Brehin, Camille, Secher, Thomas, Saoudi, Abdelhadi, Oswald, Eric, Bernard-Cadenat, Isabelle, Gillet, Marion, Ménard, Sandrine, Boury, Michèle, Watrin, Claude, Olier, Maïwenn, Payros, Delphine, Theodorou, Vassilia   +11 more
core   +1 more source