Results 41 to 50 of about 2,764 (156)

Diagnostic potential of various laboratory tests for irritable bowel syndrome (IBS): a systematic review

Journal of the Pakistan Medical Association
Objective: To identify possible tests along with their accuracies that may be used to diagnose irritable bowel syndrome. Method: The systematic review comprised literature search on Cochrane Library, PubMed, Science Direct and Elsevier databases for ...
Misha Mansoor, Muhammad Hamza Shafiq, Mahnoor Imran, Fiza Mushtaq, Sana Iftikhar, Fuad Shafiq   +5 more
doaj   +1 more source

Cytolethal Distending Toxin Damages the Oral Epithelium of Gingival Explants [PDF]

Journal of Dental Research, 2011
The cytolethal distending toxin (Cdt), expressed by the periodontal pathogen Aggregatibacter actinomycetemcomitans, inhibits the proliferation of cultured epithelial cells by arresting the cell cycle. The gingival epithelium is an early line of defense against microbial assault.
Damek-Poprawa, M., Haris, M., Volgina, A., Korostoff, J., DiRienzo, J. M.   +4 more
openaire   +3 more sources

In vivovirulence properties of bacterial cytolethal-distending toxin [PDF]

Cellular Microbiology, 2008
Multiple pathogenic Gram-negative bacteria produce cytolethal-distending toxins (CDTs). CDT is typically composed of three subunits: the catalytic subunit CdtB has DNase I-like activity, whereas CdtA and CdtC are binding proteins for delivering CdtB into target cells.
Zhongming, Ge, David B, Schauer, James G, Fox   +2 more
openaire   +2 more sources

A possible role of urinary genotoxic Escherichia coli in prostate cancer in Nigerian patients

BMC Research Notes
Objective Infection and inflammation are potential initiating factors for the development and progression of prostate cancer. This study investigated the presence of bacterial genotoxins; colibactin (clb) and cytolethal distending toxin (cdt) in ...
Sharon O. Akinpelu, Grace I. Olasehinde, Olayemi O. Akinnola   +2 more
doaj   +1 more source

Cytolethal distending toxin enhances Escherichia coli urinary tract infection

Infection and Immunity
Cytolethal distending toxin (CDT) is a virulence factor produced by several gram-negative bacteria, including Escherichia coli, the most prevalent etiological agent of urinary tract infections (UTIs). CDT causes DNA damage to eukaryotic cells, leading to
Santosh Paudel, Benjamin E. Curtis, Siena Stefa, Harry L. T. Mobley, Melanie M. Pearson, Mark T. Anderson   +5 more
doaj   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Escherichia albertii in Wild and Domestic Birds

Emerging Infectious Diseases, 2010
Escherichia albertii has been associated with diarrhea in humans but not with disease or infection in animals. However, in December 2004, E. albertii was found, by biochemical and genetic methods, to be the probable cause of death for redpoll finches ...
J. Lindsay Oaks, Thomas E. Besser, Seth T. Walk, David M. Gordon, Kimberlee B. Beckmen, Kathy A. Burek, Gary J. Haldorson, Dan S. Bradway, Lindsey Ouellette, Fred R. Rurangirwa, Margaret A. Davis, Greg Dobbin, Thomas S. Whittam   +12 more
doaj   +1 more source

Localized Periodontitis in Young Individuals: Aggregatibacter JP2 Clone, Immunological Dysfunctions and Other Stories

Journal of Periodontal Research, EarlyView.
This review describes the features of grade C molar‐incisor pattern periodontitis and discusses the role of A. actinomycetemcomitans in its pathogenesis and why molars and incisors are preferably affected. Possible future studies on this aggressive disease in primary and permanent dentition and emerging omics techniques for diagnosis and management are
Luigi Nibali, Meaad M. Alamri, Manuela Maria Viana Miguel, Luciana Shaddox   +3 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Cytolethal Distending Toxin Demonstrates Genotoxic Activity in a Yeast Model [PDF]

Infection and Immunity, 2001
ABSTRACTCytolethal distending toxins (CDTs) are multisubunit proteins produced by a variety of bacterial pathogens that cause enlargement, cell cycle arrest, and apoptosis in mammalian cells. While their function remains uncertain, recent studies suggest that they can act as intracellular DNases in mammalian cells. Here we establish a novel yeast model
D C, Hassane, R B, Lee, M D, Mendenhall, C L, Pickett   +3 more
openaire   +2 more sources