Results 41 to 50 of about 3,428 (189)

Prevalence of Cytolethal Distending Toxin Production in Periodontopathogenic Bacteria [PDF]

Journal of Clinical Microbiology, 2003
ABSTRACTCytolethal distending toxin (CDT) is a newly identified virulence factor produced by several pathogenic bacteria implicated in chronic infection. Seventy three strains of periodontopathogenic bacteria were examined for the production of CDT by a HeLa cell bioassay and for the presence of thecdtgene by PCR with degenerative oligonucleotide ...
Yamano, R, Ohara, M, Nishikubo, S, Fujiwara, Toru, Kawamoto, T, Ueno, Y, Komatsuzawa, H, Okuda, Keiko, Kurihara, H, Suginaka, H, Oswald, Eric, Tanne, K, Sugai, M   +12 more
openaire   +3 more sources

Cellular responses to the DNA damaging cytolethal distending toxin

, 2009
Cytolethal distending toxin (CDT) is a genotoxin, which belongs to a group of bacterial protein toxins called cyclomodulins. These are characterized by their interference with the eukaryotic cell cycle. CDT causes DNA damage, which induces cell cycle arrest and apoptosis.
Lina Guerra (85942)
openaire   +2 more sources

Cytolethal distending toxin: creating a gap in the cell cycle [PDF]

Journal of Medical Microbiology, 2005
Cytolethal distending toxin (CDT) is a novel bacterial toxin that is produced by a variety of pathogenic bacteria. The mechanism of cytotoxicity of CDT is unique in that it enters into eukaryotic cells and breaks double-stranded DNA. This initiates the cell's own DNA damage-response mechanisms, resulting in the arrest of the cell cycle at the G2/M ...
Wendy, Heywood, Brian, Henderson, Sean P, Nair   +2 more
openaire   +2 more sources

Impact of CDT Toxin on Human Diseases

Toxins, 2016
Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the ...
Tiphanie Faïs, Julien Delmas, Arnaud Serres, Richard Bonnet, Guillaume Dalmasso   +4 more
doaj   +1 more source

Investigation of cytolethal distending toxin production and virulence genes in Campylobacter isolates from cattle

, 2013
The prevalence of virulence and cytolethal distending toxin (Cdt) genes was investigated in isolates of Campylobacter jejuni, C. coli, C. lanienae and C. lari originated from intestinal contents and gall bladders of clinically healthy cattle.
Acik, M. N., Karagulle, B., Ongor, H., Karahan, M., Cetinkaya, B.   +4 more
core   +3 more sources

Biogenesis of the Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin Holotoxin [PDF]

Infection and Immunity, 2006
ABSTRACT The cell cycle G 2 /M specific inhibitor cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans is composed of CdtA, CdtB, and CdtC coded on the cdtA , cdtB , and cdtC genes that ...
Ueno, Y, Ohara, M, Kawamoto, T, Fujiwara, Toru, Komatsuzawa, H, Oswald, Eric, Sugai, M   +6 more
openaire   +4 more sources

Characterization of putative cholesterol recognition/interaction amino acid consensus-like motif of Campylobacter jejuni cytolethal distending toxin C. [PDF]

PLoS ONE, 2013
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni comprises a heterotrimeric complex formed by CdtA, CdtB, and CdtC. Among these toxin subunits, CdtA and CdtC function as essential proteins that mediate toxin binding to cytoplasmic ...
Chih-Ho Lai, Cheng-Kuo Lai, Ying-Ju Lin, Chiu-Lien Hung, Chia-Han Chu, Chun-Lung Feng, Chia-Shuo Chang, Hong-Lin Su   +7 more
doaj   +1 more source

A Bacterial Toxin that Causes DNA Damage to Modulate Cellular Responses

The Scientific World Journal, 2001
Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world [1]. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) [2] which causes intoxicated cells to enlarge and to stop
Maria Lara-Tejero
doaj   +1 more source

Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Frontiers in Cellular and Infection Microbiology, 2017
Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion.
Rachid A. El-Aouar Filho, Rachid A. El-Aouar Filho, Aurélie Nicolas, Thiago L. De Paula Castro, Martine Deplanche, Vasco A. De Carvalho Azevedo, Pierre L. Goossens, Frédéric Taieb, Gerard Lina, Gerard Lina, Gerard Lina, Yves Le Loir, Nadia Berkova   +12 more
doaj   +1 more source

Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells. [PDF]

PLoS Pathog, 2019
International audienceHumans are frequently exposed to bacterial genotoxins involved in digestive cancers, colibactin and Cytolethal Distending Toxin (CDT), the latter being secreted by many pathogenic bacteria.
Azzi-Martin L, He W, Péré-Védrenne C, Korolik V, Alix C, Prochazkova-Carlotti M, Morel JL, Le Roux-Goglin E, Lehours P, Djavaheri-Mergny M, Grosset CF, Varon C, Dubus P, Ménard A.   +13 more
europepmc   +2 more sources