Results 41 to 50 of about 128,137 (125)

The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective

Cells, 2014
The cytolethal distending toxin (CDT) is produced by many pathogenic Gram-negative bacteria and is considered as a virulence factor. In human cells, CDT exposure leads to a unique cytotoxicity associated with a characteristic cell distension and induces
Elisabeth Bezine, Julien Vignard, Gladys Mirey   +2 more
doaj   +1 more source

Cholesterol Depletion Reduces Entry of Campylobacter jejuni Cytolethal Distending Toxin and Attenuates Intoxication of Host Cells

, 2011
Campylobacter jejuni is a common cause of pediatric diarrhea worldwide. Cytolethal distending toxin, produced by Campylobacter jejuni, is a putative virulence factor that induces cell cycle arrest and apoptosis in eukaryotic cells.
Lai, C.K., 蘇鴻麟, Chang, Y.C., Wen-Ching Wang, Cheng-Kuo Lai, Chen, K.C., Yun-Chieh Chang, Jer-Tsong Hsieh, Yu-Ting Sing, Wang, W.C., Lin, Y.H., Lai, C.H., Chia-Der Lin, Sing, Y.T., Hong-Lin Su, Yu-Hsin Lin, Hsieh, J.T., Kai-Chuan Chen, Su, H.L., Chih-Ho Lai, Lin, C.D.   +20 more
core   +1 more source

Prevalence of virulence genes and cytolethal distending toxin production in campylobacter jejuni isolates from diarrheal patients in Bangladesh? [PDF]

, 2008
From 300 stool samples, 58 Campylobacter strains were isolated by standard microbiological and biochemical methods. Of these, 40 strains were identified as Campylobacter jejuni and 5 as Campylobacter coli.
Sack, David A., Aslam, Mohammad, Dutta, Dilip K., Talukder, Kaisar A., Azmi, Ishrat J., Hossain, Sabir, Endtz , Hubert P., Cravioto, Alejandro, Islam, Zhahirul, Nair, Gopinath B., Nur-E-Kama, Alam   +10 more
core   +3 more sources

Cytolethal Distending Toxin Enhances Radiosensitivity in Prostate Cancer Cells by Regulating Autophagy

Frontiers in Cellular and Infection Microbiology, 2017
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB, and CdtC. Among these three toxin subunits, CdtB is the toxic moiety of CDT with DNase I activity, resulting in DNA double-strand breaks (DSB) and ...
Hwai-Jeng Lin, Hwai-Jeng Lin, Hsin-Ho Liu, Hsin-Ho Liu, Chia-Der Lin, Chia-Der Lin, Min-Chuan Kao, Yu-An Chen, Chuan Chiang-Ni, Chuan Chiang-Ni, Zhi-Pei Jiang, Mei-Zi Huang, Chun-Jung Lin, U-Ging Lo, Li-Chiung Lin, Li-Chiung Lin, Cheng-Kuo Lai, Ho Lin, Jer-Tsong Hsieh, Cheng-Hsun Chiu, Cheng-Hsun Chiu, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai   +24 more
doaj   +1 more source

Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells. [PDF]

PLoS Pathog, 2019
International audienceHumans are frequently exposed to bacterial genotoxins involved in digestive cancers, colibactin and Cytolethal Distending Toxin (CDT), the latter being secreted by many pathogenic bacteria.
Azzi-Martin L, He W, Péré-Védrenne C, Korolik V, Alix C, Prochazkova-Carlotti M, Morel JL, Le Roux-Goglin E, Lehours P, Djavaheri-Mergny M, Grosset CF, Varon C, Dubus P, Ménard A.   +13 more
europepmc   +2 more sources

Molecular mechanisms and potential clinical applications of Campylobacter jejuni cytolethal distending toxin

Frontiers in Cellular and Infection Microbiology, 2016
Cytolethal distending toxin (CDT), a genotoxin produced by Campylobacter jejuni, is composed of three subunits: CdtA, CdtB, and CdtC. CdtB is a DNase that causes DNA double-strand breaks (DSB) in the nucleus resulting in cell cycle arrest at the G2/M ...
Cheng-Kuo eLai, Yu-An eChen, Chun-Jung eLin, Hwai-Jeng eLin, Min-Chuan eKao, Mei-Zi eHuang, Yu-Hsin eLin, Chuan eChiang-Ni, Chih-Jung eChen, U-Ging eLo, Li-Chiung eLin, Ho eLin, Jer-Tsong eHsieh, Chih-Ho eLai   +13 more
doaj   +1 more source

Bacterial Genotoxins: Merging the DNA Damage Response into Infection Biology

Biomolecules, 2015
Bacterial genotoxins are unique among bacterial toxins as their molecular target is DNA. The consequence of intoxication or infection is induction of DNA breaks that, if not properly repaired, results in irreversible cell cycle arrest (senescence) or ...
Francesca Grasso, Teresa Frisan
doaj   +1 more source

Alteration of homeostasis in pre-osteoclasts induced by Aggregatibacter actinomycetemcomitans CDT

Frontiers in Cellular and Infection Microbiology, 2016
The dysbiotic microbiota associated with aggressive periodontitis includes Aggregatibacter actinomycetemcomitans, the only oral species known to produce a cytolethal distending toxin (AaCDT). Given that CDT alters the cytokine profile in monocytic cells,
Dione eKawamoto, Ellen Sayuri Ando-Sugimoto, Bruno eBueno-Silva, Joseph M. DiRienzo, Marcia Pinto Alves Mayer   +4 more
doaj   +1 more source

A new functional site W115 in CdtA is critical for Aggregatibacter actinomycetemcomitans cytolethal distending toxin. [PDF]

PLoS ONE, 2013
Aggregatibacter actinomycetemcomitans, a specific pathogen of localized aggressive periodontitis, produces a cytolethal distending toxin (CDT) that arrests eukaryotic cells irreversibly in G0/G1 or G2/M phase of the cell cycle.
Lu Li, Cheng Ding, Jun-lan Duan, Mi-fang Yang, Ying Sun, Xiao-qian Wang, Yan Xu   +6 more
doaj   +1 more source

Single nucleotide polymorphism in the cytolethal distending toxin B gene confers heterogeneity in the cytotoxicity of A. actinomycetemcomitans [PDF]

, 2006
Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers varying from 102 to 108 U/mg. SNP analysis of the Cdt gene in clinical isolates identified a variation of single amino acid at residue 281 of CdtB, which
Ohara, Masaru, Kurihara, Hidemi, Nishikubo, Shuichi, Katayanagi, Katsuo, Fujiwara, Tamaki, Ikura, Masae, Komatsuzawa, Hitoshi, Sugai, Motoyuki   +7 more
core   +1 more source